Abstract: The present invention relates to novel SMAC mimetic peptidomimetics useful for the treatment of proliferative diseases including cancer in mammals The novel SMAC mimetics are prepared by incorporating (2S,5R)-5-(5-methylfuran-2-yl)pyrrolidine-2-carboxylic acid, a novel unnatural amino acid that imparts exclusively trans amide bond geometry favourable for target protein binding. Here, the novel SMAC mimetic molecule(s) not only show its efficacy in varied cancer types but also demonstrate in vitro and in vivo efficacy against therapy resistant cancer as a single agent. The novel SMAC mimetics disclosed in the present invention binds to BIR-2 and BIR-3 domains of the XIAP and exhibit high anti-proliferative activity against variety of mammalian cancer cell lines that include but not limited to chemotherapy and TRAIL resistant cell lines.

Abstract: A spiral hose includes: a tube with a first wall thickness; a first reinforcement package, arranged around a circumference of the tube, having a first rubber layer embedding at least one set of a first and second layer of wire wound in a helical path around the tube, a winding direction of the first layer being opposite from a winding direction of the second layer, which first reinforcement package has a first package thickness; a second reinforcement package, arranged around a circumference of the first reinforcement package, having a second rubber layer embedding at least a second set of a third and fourth layer of wire wound in a helical path around the first reinforcement package, a winding direction of the third layer being opposite from a winding direction of the fourth layer, which second reinforcement package has a second package thickness; and a cover layer.

Abstract: Described is a hose and a method of manufacturing a hose. The hose comprises: an inner tube for communicating fluid; a reinforcement layer positioned over the inner tube; an intermediate cover positioned over the reinforcement layer, wherein the intermediate cover has a thickness of between 1.3 mm and 3.0 mm and comprises a material having a hardness of between 40 Shore A and 60 Shore A; and an outer cover comprising an abrasion resistant material.

Abstract: A metal braided hose includes: an inner tube including an elastic material; a first metal wire braided layer enveloping an outer surface of the inner tube; and a second metal wire braided layer enveloping the first metal wire braided layer. A wire thickness of the second metal wire braided layer is smaller than a wire thickness of the first metal wire braided layer.

Abstract: A spiral hose includes: a tube with a first wall thickness; a first reinforcement package, arranged around a circumference of the tube, having a first rubber layer embedding at least one set of a first and second layer of wire wound in a helical path around the tube, a winding direction of the first layer being opposite from a winding direction of the second layer, which first reinforcement package has a first package thickness; a second reinforcement package, arranged around a circumference of the first reinforcement package, having a second rubber layer embedding at least a second set of a third and fourth layer of wire wound in a helical path around the first reinforcement package, a winding direction of the third layer being opposite from a winding direction of the fourth layer, which second reinforcement package has a second package thickness; and a cover layer.

Abstract: A metal braided hose includes: an inner tube including an elastic material; a first metal wire braided layer enveloping an outer surface of the inner tube; and a second metal wire braided layer enveloping the first metal wire braided layer. A wire thickness of the second metal wire braided layer is smaller than a wire thickness of the first metal wire braided layer.

Abstract: The disclosure describes a tool that decreases the size of a software installation file by segregating and/or allowing customization of the original software installation file. The resulting install file permits multiple configurations to be created using the same install file by using custom configuration settings. The optimized software installation file permits the automated (or semi-automated) installation of software and/or software updates/upgrades on a remotely located electronic device. Moreover, aspects of the tool may also regulate compliance with possible reboot/restart requirements of the software/upgrade installation that may be useful for electronic devices which are remotely located.

Abstract: A hydraulic hose includes: an innermost layer tube encircling at least one channel. The innermost layer tube has a self-sealing material composition including an elastomeric material and a polyalkyleneimine. In an embodiment, the polyalkyleneimine is selected from polyethyleneimine, polypropyleneimine, polybutyleneimine, and polypentyleneimine. In an embodiment, the polyalkyleneimine is linear or branched.

Abstract: The disclosure describes a tool that decreases the size of a software installation file by segregating and/or allowing customization of the original software installation file. The resulting install file permits multiple configurations to be created using the same install file by using custom configuration settings. The optimized software installation file permits the automated (or semi-automated) installation of software and/or software updates/upgrades on a remotely located electronic device. Moreover, aspects of the tool may also regulate compliance with possible reboot/restart requirements of the software/upgrade installation that may be useful for electronic devices which are remotely located.

Abstract: The disclosure describes a tool that decreases the size of a software installation file by segregating and/or allowing customization of the original software installation file. The resulting install file permits multiple configurations to be created using the same install file by using custom configuration settings. The optimized software installation file permits the automated (or semi-automated) installation of software and/or software updates/upgrades on a remotely located electronic device. Moreover, aspects of the tool may also regulate compliance with possible reboot/restart requirements of the software/upgrade installation that may be useful for electronic devices which are remotely located.

Abstract: The disclosure describes a tool that decreases the size of a software installation file by segregating and/or allowing customization of the original software installation file. The resulting install file permits multiple configurations to be created using the same install file by using custom configuration settings. The optimized software installation file permits the automated (or semi-automated) installation of software and/or software updates/upgrades on a remotely located electronic device. Moreover, aspects of the tool may also regulate compliance with possible reboot/restart requirements of the software/upgrade installation that may be useful for electronic devices which are remotely located.