Patents by Inventor Dipankar Koley
Dipankar Koley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240083846Abstract: The present invention relates to novel SMAC mimetic peptidomimetics useful for the treatment of proliferative diseases including cancer in mammals The novel SMAC mimetics are prepared by incorporating (2S,5R)-5-(5-methylfuran-2-yl)pyrrolidine-2-carboxylic acid, a novel unnatural amino acid that imparts exclusively trans amide bond geometry favourable for target protein binding. Here, the novel SMAC mimetic molecule(s) not only show its efficacy in varied cancer types but also demonstrate in vitro and in vivo efficacy against therapy resistant cancer as a single agent. The novel SMAC mimetics disclosed in the present invention binds to BIR-2 and BIR-3 domains of the XIAP and exhibit high anti-proliferative activity against variety of mammalian cancer cell lines that include but not limited to chemotherapy and TRAIL resistant cell lines.Type: ApplicationFiled: December 17, 2021Publication date: March 14, 2024Inventors: Wahajul HAQ, Rafat ALI, Akhilesh SINGH, Mushtaq Ahmad NENGROO, Roshan KATEKAR, Gajendra SINGH, Jayanti VAISHNAV, Mohammad AFSAR, Manohar SINGH, Srikanta Kumar RATH, Dipankar KOLEY, Durga Prasad MISHRA, Ravishankar RAMACHANDRAN, Ravi Sankar AMPAPATHI, Jiaur Rahaman GAYEN, Dipak DATTA
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Patent number: 11413420Abstract: A gas delivery device includes a nitric oxide generating system. The system has a medium including i) a source of nitrite ions, or ii) a source of nitrite ions and a Cu(II)-ligand complex. A working electrode is in contact with the medium, wherein i) when the medium includes the source of nitrite ions, the working electrode is a copper containing conductive material or a base material coated with a copper containing conductive material, or ii) when the medium includes the source of nitrite ions and the Cu(II)-ligand complex, the working electrode is platinum, gold, carbon, a carbon coated material, and/or mercury. A reference/counter electrode is in contact with the medium and electrically isolated from the working electrode. An inlet conduit is to deliver oxygen gas to the medium, and an outlet conduit is to transport a stream of oxygen gas and nitric oxide from the medium.Type: GrantFiled: January 24, 2020Date of Patent: August 16, 2022Assignee: The Regents of the University of MichiganInventors: Mark E. Meyerhoff, Lajos Hofler, Dipankar Koley, Hang Ren
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Publication number: 20220144758Abstract: Multifunctional dendritic molecular probes that selectively detect Cu2+ ions via potentiometric and fluorometric techniques with low detection limits are disclosed. The selective and reversible binding of the molecules with the Cu2+ ion was used to make solid-state microsensors by incorporating the molecular probes into the carbon-based membranes as an ionophore for Cu (II).Type: ApplicationFiled: November 12, 2021Publication date: May 12, 2022Applicant: Oregon State UniversityInventors: Dipankar Koley, Partha Sarathi Sheet
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Publication number: 20200164174Abstract: A gas delivery device includes a nitric oxide generating system. The system has a medium including i) a source of nitrite ions, or ii) a source of nitrite ions and a Cu(II)-ligand complex. A working electrode is in contact with the medium, wherein i) when the medium includes the source of nitrite ions, the working electrode is a copper containing conductive material or a base material coated with a copper containing conductive material, or ii) when the medium includes the source of nitrite ions and the Cu(II)-ligand complex, the working electrode is platinum, gold, carbon, a carbon coated material, and/or mercury. A reference/counter electrode is in contact with the medium and electrically isolated from the working electrode. An inlet conduit is to deliver oxygen gas to the medium, and an outlet conduit is to transport a stream of oxygen gas and nitric oxide from the medium.Type: ApplicationFiled: January 24, 2020Publication date: May 28, 2020Inventors: Mark E. Meyerhoff, Lajos Hofler, Dipankar Koley, Hang Ren
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Patent number: 10543337Abstract: A gas delivery device includes a nitric oxide generating system. The system has a medium including i) a source of nitrite ions, or ii) a source of nitrite ions and a Cu(II)-ligand complex. A working electrode is in contact with the medium, wherein i) when the medium includes the source of nitrite ions, the working electrode is a copper containing conductive material or a base material coated with a copper containing conductive material, or ii) when the medium includes the source of nitrite ions and the Cu(II)-ligand complex, the working electrode is platinum, gold, carbon, a carbon coated material, and/or mercury. A reference/counter electrode is in contact with the medium and electrically isolated from the working electrode. An inlet conduit is to deliver oxygen gas to the medium, and an outlet conduit is to transport a stream of oxygen gas and nitric oxide from the medium.Type: GrantFiled: August 2, 2016Date of Patent: January 28, 2020Assignee: The Regents of the University of MichiganInventors: Mark E. Meyerhoff, Lajos Hofler, Dipankar Koley, Hang Ren
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Patent number: 9872953Abstract: A nitric oxide delivery device includes a housing that is permeable to nitric oxide. A working electrode (which is a copper-containing conductive material or a base material coated with a copper-containing conductive material) is positioned inside of the housing. A conductive lead is electrically connected to the working electrode and extends outside of the housing. A reference electrode and/or a counter electrode is electrically isolated from the working electrode. The reference electrode and/or the counter electrode has a first portion that is inside of the housing and a second conductive portion that is outside of the housing. A source of nitrite ions is to be contained within the housing such that it is in contact with the working electrode.Type: GrantFiled: March 28, 2013Date of Patent: January 23, 2018Assignee: The Regents of the University of MichiganInventors: Lajos Hofler, Mark E. Meyerhoff, Dipankar Koley
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Publication number: 20160339197Abstract: A gas delivery device includes a nitric oxide generating system. The system has a medium including i) a source of nitrite ions, or ii) a source of nitrite ions and a Cu(II)-ligand complex. A working electrode is in contact with the medium, wherein i) when the medium includes the source of nitrite ions, the working electrode is a copper containing conductive material or a base material coated with a copper containing conductive material, or ii) when the medium includes the source of nitrite ions and the Cu(II)-ligand complex, the working electrode is platinum, gold, carbon, a carbon coated material, and/or mercury. A reference/counter electrode is in contact with the medium and electrically isolated from the working electrode. An inlet conduit is to deliver oxygen gas to the medium, and an outlet conduit is to transport a stream of oxygen gas and nitric oxide from the medium.Type: ApplicationFiled: August 2, 2016Publication date: November 24, 2016Inventors: Mark E. Meyerhoff, Lajos Hofler, Dipankar Koley, Hang Ren
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Patent number: 9498571Abstract: A nitric oxide delivery device includes a housing that is permeable to nitric oxide. The surface of the housing is modified to detect surface charge or pH (e.g., due to cell adhesion). A working electrode (which is a copper-containing conductive material or a base material coated with a copper-containing conductive material) is positioned inside of the housing. A reference/counter electrode is also positioned inside of the housing, and is electrically isolated from the working electrode. A source of nitrite ions is to be contained within the housing such that it is in contact with the working electrode.Type: GrantFiled: March 28, 2013Date of Patent: November 22, 2016Assignee: The Regents of the University of MichiganInventors: Lajos Hofler, Mark E. Meyerhoff, Dipankar Koley
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Patent number: 9480785Abstract: An example of a nitric oxide delivery device includes a medium, a working electrode in contact with the medium, and a reference/counter electrode in contact with the medium and electrically isolated from the working electrode. The medium includes a source of nitrite ions and a Cu(II)-ligand complex. A nitric oxide permeable material separates the medium from an external environment that is to contain blood.Type: GrantFiled: December 7, 2013Date of Patent: November 1, 2016Assignee: The Regents of the University of MichiganInventors: Mark E. Meyerhoff, Lajos Hofler, Dipankar Koley, Hang Ren
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Publication number: 20150073331Abstract: A nitric oxide delivery device includes a housing that is permeable to nitric oxide. A working electrode (which is a copper-containing conductive material or a base material coated with a copper-containing conductive material) is positioned inside of the housing. A conductive lead is electrically connected to the working electrode and extends outside of the housing. A reference electrode and/or a counter electrode is electrically isolated from the working electrode. The reference electrode and/or the counter electrode has a first portion that is inside of the housing and a second conductive portion that is outside of the housing. A source of nitrite ions is to be contained within the housing such that it is in contact with the working electrode.Type: ApplicationFiled: March 28, 2013Publication date: March 12, 2015Inventors: Lajos Hofler, Mark E. Meyerhoff, Dipankar Koley
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Publication number: 20140294672Abstract: An example of a nitric oxide delivery device includes a medium, a working electrode in contact with the medium, and a reference/counter electrode in contact with the medium and electrically isolated from the working electrode. The medium includes a source of nitrite ions and a Cu(II)-ligand complex. A nitric oxide permeable material separates the medium from an external environment that is to contain blood.Type: ApplicationFiled: December 7, 2013Publication date: October 2, 2014Applicant: The Regents of the University of MichiganInventors: Mark E. Meyerhoff, Lajos Hofler, Dipankar Koley, Hang Ren
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Publication number: 20130261537Abstract: A nitric oxide delivery device includes a housing that is permeable to nitric oxide. The surface of the housing is modified to detect surface charge or pH (e.g., due to cell adhesion). A working electrode (which is a copper-containing conductive material or a base material coated with a copper-containing conductive material) is positioned inside of the housing. A reference/counter electrode is also positioned inside of the housing, and is electrically isolated from the working electrode. A source of nitrite ions is to be contained within the housing such that it is in contact with the working electrode.Type: ApplicationFiled: March 28, 2013Publication date: October 3, 2013Applicant: The Regents of the University of MichiganInventors: Lajos Hofler, Mark E. Meyerhoff, Dipankar Koley