Patents by Inventor Diping Che

Diping Che has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bio-imaging devices and methods of using same
    Patent number: 12568307
    Abstract: Biological systems and methods of using same are disclosed. The systems comprise a biological imaging device and a mobile computing device in communication therewith. The biological imaging device includes a single-board computer embedded with control software, enabling remote operation and image acquisition from the mobile computing device without installing the control software thereon, thereby enhancing operational efficiency and user convenience.
    Type: Grant
    Filed: July 28, 2023
    Date of Patent: March 3, 2026
    Assignee: Azure Biosystems Inc.
    Inventors: Diping Che, Lipo Xu, Sanmen Liu, Yanzhou Kang, Zhefu Zhang
  • BIO-IMAGING DEVICES AND METHODS OF USING SAME
    Publication number: 20240040242
    Abstract: The present disclosure provides devices for imaging biological substrates and methods of using same to obtain images of biological substrates.
    Type: Application
    Filed: July 28, 2023
    Publication date: February 1, 2024
    Inventors: Diping Che, Lipo Xu, Sanmen Liu, Yanzhou Kang, Zhefu Zhang
  • MULTI-CHANNEL BIO-IMAGING DEVICES AND METHODS OF USING SAME
    Publication number: 20240035977
    Abstract: The present disclosure provides bio-imaging devices including multiple, modular channels for imaging biological substrates, and methods of using same to obtain mono- or multi-channel images of biological substrates.
    Type: Application
    Filed: July 28, 2023
    Publication date: February 1, 2024
    Inventors: Diping Che, Wei Ding, Kun Li, Yuming Zhang, Zhefu Zhang
  • DEVICES AND METHODS FOR IMAGING BIOMOLECULES
    Publication number: 20210181112
    Abstract: The present disclosure provides devices and methods enabling the analysis of biomolecules. In some embodiments, the biomolecules may be DNA, RNA, protein, peptide, small molecule, catalyst, precursor, nucleotide, antibodies, or other biomolecules of interest.
    Type: Application
    Filed: February 2, 2021
    Publication date: June 17, 2021
    Inventors: Diping Che, Zhefu Zhang
  • Devices and methods for imaging biomolecules
    Patent number: 10989662
    Abstract: The present disclosure provides devices and methods enabling the analysis of biomolecules. In some embodiments, the biomolecules may be DNA, RNA, protein, peptide, small molecule, catalyst, precursor, nucleotide, antibodies, or other biomolecules of interest.
    Type: Grant
    Filed: March 28, 2019
    Date of Patent: April 27, 2021
    Assignee: Azure Biosystems, Inc.
    Inventors: Diping Che, Zhefu Zhang
  • METHODS AND DEVICES FOR PHOTOMETRIC ANALYSIS
    Publication number: 20210109023
    Abstract: The present disclosure provides methods and devices for characterizing light-generating analytes.
    Type: Application
    Filed: November 18, 2020
    Publication date: April 15, 2021
    Inventor: Diping Che
  • Microscope for locating structures on the inner surface of a fluidic channel
    Patent number: 10895727
    Abstract: A microscope has a fiducial mask and fiducial lens generating a collimated mask image onto a beam splitter which directs the optical image to an objective lens where it is directed to an optical discontinuity formed by the change of index of refraction of the inner surface of a fluidic channel. Reflected optical energy is directed through the objective lens, the beam splitter, and a detector lens to a detector. A focused image forms when an inner surface of the fluidic channel is a focal distance from the objective lens, providing for imaging of fluorescent labels at the inner surface of the fluidic channel.
    Type: Grant
    Filed: October 19, 2019
    Date of Patent: January 19, 2021
    Inventors: James Che, Diping Che
  • DEVICES AND METHODS FOR IMAGING BIOMOLECULES
    Publication number: 20190226993
    Abstract: The present disclosure provides devices and methods enabling the analysis of biomolecules. In some embodiments, the biomolecules may be DNA, RNA, protein, peptide, small molecule, catalyst, precursor, nucleotide, antibodies, or other biomolecules of interest.
    Type: Application
    Filed: March 28, 2019
    Publication date: July 25, 2019
    Inventors: Diping Che, Zhefu Zhang
  • Devices and methods for imaging biomolecules
    Patent number: 10281402
    Abstract: The present disclosure provides devices and methods enabling the analysis of biomolecules. In some embodiments, the biomolecules may be DNA, RNA, protein, peptide, small molecule, catalyst, precursor, nucleotide, antibodies, or other biomolecules of interest.
    Type: Grant
    Filed: January 26, 2018
    Date of Patent: May 7, 2019
    Assignee: Azure Biosystems, Inc.
    Inventors: Diping Che, Zhefu Zhang
  • SHIPPING CASE WITH LIFT MECHANISM
    Publication number: 20190112170
    Abstract: The present disclosure provides cases comprising a lift mechanism, kits comprising a case and an instrument, and methods of using same.
    Type: Application
    Filed: October 16, 2018
    Publication date: April 18, 2019
    Inventors: Diping Che, Zhefu Zhang
  • DEVICES AND METHODS FOR IMAGING BIOMOLECULES
    Publication number: 20180209908
    Abstract: The present disclosure provides devices and methods enabling the analysis of biomolecules. In some embodiments, the biomolecules may be DNA, RNA, protein, peptide, small molecule, catalyst, precursor, nucleotide, antibodies, or other biomolecules of interest.
    Type: Application
    Filed: January 26, 2018
    Publication date: July 26, 2018
    Inventors: Diping Che, Zhefu Zhang
  • METHODS AND DEVICES FOR PHOTOMETRIC ANALYSIS
    Publication number: 20180088049
    Abstract: The present disclosure provides methods and devices for characterizing light-generating analytes.
    Type: Application
    Filed: September 26, 2017
    Publication date: March 29, 2018
    Applicant: AZURE BIOSYSTEMS, INC.
    Inventor: Diping Che
  • Confocal imaging methods and apparatus
    Patent number: 9816929
    Abstract: The invention provides imaging apparatus and methods useful for obtaining a high resolution image of a sample at rapid scan rates. A rectangular detector array having a horizontal dimension that is longer than the vertical dimension can be used along with imaging optics positioned to direct a rectangular image of a portion of a sample to the rectangular detector array. A scanning device can be configured to scan the sample in a scan-axis dimension, wherein the vertical dimension for the rectangular detector array and the shorter of the two rectangular dimensions for the image are in the scan-axis dimension, and wherein the vertical dimension for the rectangular detector array is short enough to achieve confocality in a single axis.
    Type: Grant
    Filed: September 18, 2014
    Date of Patent: November 14, 2017
    Assignee: ILLUMINA, INC.
    Inventors: Wenyi Feng, Theofilos Kotseroglou, Mark Wang, Alexander Triener, Diping Che, Robert Kain
  • CONFOCAL IMAGING METHODS AND APPARATUS
    Publication number: 20150069267
    Abstract: The invention provides imaging apparatus and methods useful for obtaining a high resolution image of a sample at rapid scan rates. A rectangular detector array having a horizontal dimension that is longer than the vertical dimension can be used along with imaging optics positioned to direct a rectangular image of a portion of a sample to the rectangular detector array. A scanning device can be configured to scan the sample in a scan-axis dimension, wherein the vertical dimension for the rectangular detector array and the shorter of the two rectangular dimensions for the image are in the scan-axis dimension, and wherein the vertical dimension for the rectangular detector array is short enough to achieve confocality in a single axis.
    Type: Application
    Filed: September 18, 2014
    Publication date: March 12, 2015
    Applicant: Illumina, Inc.
    Inventors: Wenyi Feng, Theofilos Kotseroglou, Mark Wang, Alexander Triener, Diping Che, Robert Kain
  • Confocal imaging methods and apparatus
    Patent number: 8884211
    Abstract: The invention provides imaging apparatus and methods useful for obtaining a high resolution image of a sample at rapid scan rates. A rectangular detector array having a horizontal dimension that is longer than the vertical dimension can be used along with imaging optics positioned to direct a rectangular image of a portion of a sample to the rectangular detector array. A scanning device can be configured to scan the sample in a scan-axis dimension, wherein the vertical dimension for the rectangular detector array and the shorter of the two rectangular dimensions for the image are in the scan-axis dimension, and wherein the vertical dimension for the rectangular detector array is short enough to achieve confocality in a single axis.
    Type: Grant
    Filed: March 12, 2012
    Date of Patent: November 11, 2014
    Assignee: Illumina, Inc.
    Inventors: Wenyi Feng, Theofilos Kotseroglou, Mark Wang, Alexander Triener, Diping Che, Robert Kain
  • CONFOCAL IMAGING METHODS AND APPARATUS
    Publication number: 20120168644
    Abstract: The invention provides imaging apparatus and methods useful for obtaining a high resolution image of a sample at rapid scan rates. A rectangular detector array having a horizontal dimension that is longer than the vertical dimension can be used along with imaging optics positioned to direct a rectangular image of a portion of a sample to the rectangular detector array. A scanning device can be configured to scan the sample in a scan-axis dimension, wherein the vertical dimension for the rectangular detector array and the shorter of the two rectangular dimensions for the image are in the scan-axis dimension, and wherein the vertical dimension for the rectangular detector array is short enough to achieve confocality in a single axis.
    Type: Application
    Filed: March 12, 2012
    Publication date: July 5, 2012
    Applicant: ILLUMINA, INC.
    Inventors: Wenyi Feng, Theofilos Kotseroglou, Mark Wang, Alexander Triener, Diping Che, Robert Kain
  • Confocal imaging methods and apparatus
    Patent number: 8158926
    Abstract: The invention provides imaging apparatus and methods useful for obtaining a high resolution image of a sample at rapid scan rates. A rectangular detector array having a horizontal dimension that is longer than the vertical dimension can be used along with imaging optics positioned to direct a rectangular image of a portion of a sample to the rectangular detector array. A scanning device can be configured to scan the sample in a scan-axis dimension, wherein the vertical dimension for the rectangular detector array and the shorter of the two rectangular dimensions for the image are in the scan-axis dimension, and wherein the vertical dimension for the rectangular detector array is short enough to achieve confocality in a single axis.
    Type: Grant
    Filed: May 2, 2011
    Date of Patent: April 17, 2012
    Assignee: Illumina, Inc.
    Inventors: Wenyi Feng, Theofilos Kotseroglou, Mark Wang, Alexander Triener, Diping Che, Robert Kain
  • CONFOCAL IMAGING METHODS AND APPARATUS
    Publication number: 20110204212
    Abstract: The invention provides imaging apparatus and methods useful for obtaining a high resolution image of a sample at rapid scan rates. A rectangular detector array having a horizontal dimension that is longer than the vertical dimension can be used along with imaging optics positioned to direct a rectangular image of a portion of a sample to the rectangular detector array. A scanning device can be configured to scan the sample in a scan-axis dimension, wherein the vertical dimension for the rectangular detector array and the shorter of the two rectangular dimensions for the image are in the scan-axis dimension, and wherein the vertical dimension for the rectangular detector array is short enough to achieve confocality in a single axis.
    Type: Application
    Filed: May 2, 2011
    Publication date: August 25, 2011
    Applicant: ILLUMINA, INC.
    Inventors: Wenyi Feng, Theofilos Kotseroglou, Mark Wang, Alexander Triener, Diping Che, Robert Kain
  • Confocal imaging methods and apparatus
    Patent number: 7960685
    Abstract: The invention provides imaging apparatus and methods useful for obtaining a high resolution image of a sample at rapid scan rates. A rectangular detector array having a horizontal dimension that is longer than the vertical dimension can be used along with imaging optics positioned to direct a rectangular image of a portion of a sample to the rectangular detector array. A scanning device can be configured to scan the sample in a scan-axis dimension, wherein the vertical dimension for the rectangular detector array and the shorter of the two rectangular dimensions for the image are in the scan-axis dimension, and wherein the vertical dimension for the rectangular detector array is short enough to achieve confocality in a single axis.
    Type: Grant
    Filed: August 6, 2009
    Date of Patent: June 14, 2011
    Assignee: Illumina, Inc.
    Inventors: Wenyi Feng, Theofilos Kotseroglou, Mark Wang, Alexander Triener, Diping Che, Robert Kain
  • CONFOCAL IMAGING METHODS AND APPARATUS
    Publication number: 20100012825
    Abstract: The invention provides imaging apparatus and methods useful for obtaining a high resolution image of a sample at rapid scan rates. A rectangular detector array having a horizontal dimension that is longer than the vertical dimension can be used along with imaging optics positioned to direct a rectangular image of a portion of a sample to the rectangular detector array. A scanning device can be configured to scan the sample in a scan-axis dimension, wherein the vertical dimension for the rectangular detector array and the shorter of the two rectangular dimensions for the image are in the scan-axis dimension, and wherein the vertical dimension for the rectangular detector array is short enough to achieve confocality in a single axis.
    Type: Application
    Filed: August 6, 2009
    Publication date: January 21, 2010
    Applicant: Illumina, Inc.
    Inventors: Wenyi Feng, Theofilos Kotseroglou, Mark Wang, Alexander Triener, Diping Che, Robert Kain