Patents by Inventor Dipti Sareen

Dipti Sareen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of use of the enzymes of mycothiol synthesis
    Patent number: 7560229
    Abstract: The present invention utilizes three families of bacterial enzymes, which play a key role in mycothiol biosynthesis. The three families are bacterial cysteine:glucosaminyl inositol ligases (MshC) with catalytic ligase activity for ligation of glucosaminyl inositol and cysteine, bacterial acetyl-CoA:Cys-GlcN-Ins acetyltransferases (MshD) with catalytic activity for addition of an acetyl group to Cys-GlcN-Ins and bacterial MshA glycosyltransferase with catalytic activity for production of GlcNAc-Ins. The invention provides methods for using the mycothiol biosynthesis ligases, acetyltransferases or glycosyltransferases in drug screening assays to determine compounds that inhibit activity. The invention provides for treatment of actinomycete infections in mammals using antibiotics that inhibit production or activity of the enzymes of mycothiol biosynthesis, in particular MshC, MshD or MshA, and thereby reduce the production of mycothiol and the virulence of the infecting bacteria.
    Type: Grant
    Filed: April 15, 2003
    Date of Patent: July 14, 2009
    Assignees: The Regents of the University of California, University of British Columbia
    Inventors: Dipti Sareen, Gerald L. Newton, Robert C. Fahey, Nancy Buchmeier, Micah Steffek, Yoseff Av-Gay, Mamta Rawat, Teresa Koledin
  • Methods of use of the enzymes of mycothiol synthesis
    Publication number: 20060183116
    Abstract: The present invention utilizes three families of bacterial enzymes, which play a key role in mycothiol biosynthesis. The three families are bacterial cysteine:glucosaminyl inositol ligases (MshC) with catalytic ligase activity for ligation of glucosaminyl inositol and cysteine, bacterial acetyl-CoA:Cys-GlcN-Ins acetyltransferases (MshD) with catalytic activity for addition of an acetyl group to Cys-GlcN-Ins and bacterial MshA glycosyltransferase with catalytic activity for production of GlcNAc-Ins. The invention provides methods for using the mycothiol biosynthesis ligases, acetyltransferases or glycosyltransferases in drug screening assays to determine compounds that inhibit activity. The invention provides for treatment of actinomycete infections in mammals using antibiotics that inhibit production or activity of the enzymes of mycothiol biosynthesis, in particular MshC, MshD or MshA, and thereby reduce the production of mycothiol and the virulence of the infecting bacteria.
    Type: Application
    Filed: April 15, 2003
    Publication date: August 17, 2006
    Inventors: Dipti Sareen, Gerald Newton, Robert Fahey, Nancy Buchmeier, Micah Steffek, Yoseff Av-Gay, Mamta Rawat, Teresa Koledin