Patents by Inventor Dirk Beher

Dirk Beher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MEDICAMENTS COMPRISING GLYCOSIDASE INHIBITORS
    Publication number: 20240285615
    Abstract: The present invention relates to pharmaceutical compositions and medicaments comprising the compound of formula (I) or pharmaceutically usable solvates, salts or tautomers thereof, and dosage regimens for the administration thereof to human patients.
    Type: Application
    Filed: July 5, 2021
    Publication date: August 29, 2024
    Inventors: Dirk BEHER, Bruno PERMANNE, Rolf POKORNY, Anna QUATTROPANI
  • Fused triazole derivatives as gamma secretase modulators
    Patent number: 9527853
    Abstract: The present invention provides fused bicyclic triazole derivatives of Formula (I) useful as gamma secretase modulators (GSM), for the treatment of Alzheimer's disease and related diseases.
    Type: Grant
    Filed: June 14, 2013
    Date of Patent: December 27, 2016
    Assignee: Ares Trading S.A.
    Inventors: Ben Whittaker, Chris Steele, David Hardick, Dale Mitchell, Vincent Pomel, Anna Quattropani, Dirk Beher
  • FUSED TRIAZOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS
    Publication number: 20150183790
    Abstract: The present invention provides fused bicyclic triazole derivatives of Formula (I) useful as gamma secretase modulators (GSM), for the treatment of Alzheimer's disease and related diseases.
    Type: Application
    Filed: June 14, 2013
    Publication date: July 2, 2015
    Applicant: Merck Patent GmbH
    Inventors: Ben Whittaker, Chris Steele, David Hardick, Dale Mitchell, Vincent Pomel, Anna Quattropani, Dirk Beher
  • Mutants of Human App and Their Use for the Production of Transgenice Animals
    Publication number: 20100017894
    Abstract: A modified amyloid precursor protein can be expressed from a DNA construct comprising an APP DNA sequence, or a fragment or artificial substrate thereof, encoding the mutation I45W, I45Y V46W or V46Y (numbering relative to A4CT); the use of the DNA construct in the generation of cell lines or transgenic animals and the use of these proteins or such transgenic animals in the diagnosis of Alzheimer's Disease and screening putative drugs against Alzheimer's Disease are also described.
    Type: Application
    Filed: June 13, 2006
    Publication date: January 21, 2010
    Inventors: Dirk Beher, Jonathan David Wrigley
  • Upregulation of Adamts4 Protease Activity for the Treatment of Alzheimer's Disease
    Publication number: 20090305314
    Abstract: The invention provides methods of identifying compounds suitable for treating Alzheimer's disease and related conditions by means of modulation of ADAMTS4.
    Type: Application
    Filed: January 30, 2007
    Publication date: December 10, 2009
    Inventors: Dirk Beher, Jonathon Wrigley
  • Assay Method
    Publication number: 20080274476
    Abstract: There is disclosed a method for determining the activity of gamma-secretase in a text subject, using a biological sample from the subject.
    Type: Application
    Filed: December 8, 2005
    Publication date: November 6, 2008
    Inventors: Dirk Beher, Huw David Lewis, Mark Steven Shearman
  • Treatment for Alzheimer's Disease and Related Conditions
    Publication number: 20080153817
    Abstract: Compounds of formula (I): are useful in the treatment of diseases associated with deposition of ?-amyloid in the brain.
    Type: Application
    Filed: July 29, 2004
    Publication date: June 26, 2008
    Inventors: Dirk Beher, Michela Bettati, Graham David Checksfield, Ian Churcher, Victoria Alexandra Doughty, Paul Joseph Oakley, Abdul Quddus, Martin Richard Teall, Jonathan David Wrigley
  • 1-Alkyl-3-thio-substituted indole-2-alkynoic acids useful for the treatment of alzheimer's disease and related conditions
    Publication number: 20070142453
    Abstract: Compounds of formula I: modulate the activity of ?-secretase, and hence find use in treatment or prevention of Alzheimer's disease and related conditions.
    Type: Application
    Filed: November 25, 2004
    Publication date: June 21, 2007
    Inventors: Dirk Beher, Michela Bettari, Ian Churcher, Benito Munoz, Petpiboon Prasit, Abdul Quddus, Nicholas Stock, Jonathan Wrigley