Patents by Inventor Dirk Behnke

Dirk Behnke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted piperidines as renin inhibitors
    Patent number: 8022068
    Abstract: The present invention relates to compounds of the general formula (I) and the salts thereof, preferably the pharmaceutically acceptable salts thereof; in which R has the meaning explained in the description, a process for their preparation and the use of these compounds as medicines, especially as renin inhibitors.
    Type: Grant
    Filed: February 6, 2009
    Date of Patent: September 20, 2011
    Assignee: Novartis AG
    Inventors: Dirk Behnke, Peter Herold, Stjepan Jelakovic, Robert Mah, Vincenzo Tschinke
  • Substituted piperidines as renin inhibitors
    Patent number: 8022069
    Abstract: The present invention relates to compounds of the general formula (I) and the salts thereof, preferably the pharmaceutically acceptable salts thereof; in which R has the meaning explained in the description, a process for their preparation and the use of these compounds as medicines, especially as renin inhibitors.
    Type: Grant
    Filed: February 6, 2009
    Date of Patent: September 20, 2011
    Assignee: Novartis AG
    Inventors: Dirk Behnke, Peter Herold, Stjepan Jelakovic, Robert Mah, Vincenzo Tschinke
  • 4,4-DISUBSTITUTED PIPERIDINES
    Publication number: 20110212950
    Abstract: The application relates to 4,4-disubstituted piperidines of the general formula (I) and their salts, preferably their pharmaceutically acceptable salts, in which R2, has the meanings explained in the description, a process for their preparation and the use of these compounds as medicines, especially as renin inhibitors.
    Type: Application
    Filed: October 24, 2008
    Publication date: September 1, 2011
    Applicant: NOVARTIS AG
    Inventors: Dirk Behnke, Peter Herold, Stjepan Jelakovic, Nathalie Jotterand, Isabelle Lyothier, Robert Mah, Stefan Stutz, Vincenzo Tschinke
  • SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS
    Publication number: 20110053924
    Abstract: The present invention relates to compounds of the general formula (I) and the salts thereof, preferably the pharmaceutically acceptable salts thereof; in which R has the meaning explained in the description, a process for their preparation and the use of these compounds as medicines, especially as renin inhibitors.
    Type: Application
    Filed: February 6, 2009
    Publication date: March 3, 2011
    Inventors: Peter Herold, Robert Mah, Vincenzo Tschinke, Stjepan Jelakovic, Dirk Behnke
  • ORGANIC COMPOUNDS
    Publication number: 20110009399
    Abstract: The application relates to trisubstituted piperidines of the general formula (I) and their salts, preferably their pharmaceutically acceptable salts, in which R1, R2?, X, U, W, m and n have the meanings explained in the description, a process for their preparation and the use of these compounds as medicines, especially as renin inhibitors.
    Type: Application
    Filed: December 12, 2008
    Publication date: January 13, 2011
    Inventors: Peter Herold, Stjepan Jelakovic, Robert Mah, Dirk Behnke, Stefan Stutz, Vincenzo Tschinke, Nathalie Jotterand
  • Organic compounds
    Patent number: 7868036
    Abstract: The invention relates to novel amino alcohols of the general formula (I) where X, R1, R2, R3, R4, R5 and R6 are each as defined in detail in the description, to a process for their preparation and to the use of these compounds as medicines, in particular as renin inhibitors.
    Type: Grant
    Filed: March 17, 2005
    Date of Patent: January 11, 2011
    Assignee: Novartis AG
    Inventors: Peter Herold, Stefan Stutz, Robert Mah, Vincenzo Tschinke, Aleksandar Stojanovic, Nathalie Jotterand, Michael Quirmbach, Dirk Behnke, Christiane Marti
  • SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS
    Publication number: 20100331322
    Abstract: The present invention relates to compounds of the general formula (I) and the salts thereof, preferably the pharmaceutically acceptable salts thereof; in which R has the meaning explained in the description, a process for their preparation and the use of these compounds as medicines, especially as renin inhibitors.
    Type: Application
    Filed: February 6, 2009
    Publication date: December 30, 2010
    Inventors: Peter Herold, Robert Mah, Vincenzo Tschinke, Stjepan Jelakovic, Dirk Behnke
  • 5-amino 4-hydroxy-7-(1H-indolmethyl)-8-methylnonamide derivatives as renin inhibitors for the treatment of hypertension
    Patent number: 7851634
    Abstract: The application relates to novel alkanamides of the general formula (I) where X is —CH2— or >CH—OH; (A) R1 is e.g.
    Type: Grant
    Filed: March 17, 2005
    Date of Patent: December 14, 2010
    Assignee: Novartis AG
    Inventors: Peter Herold, Stefan Stutz, Robert Mah, Vincenzo Tschinke, Aleksandar Stojanovic, Nathalie Jotterand, Michael Quirmbach, Dirk Behnke, Christiane Marti
  • TRISUBSTITUTED PIPERIDINES
    Publication number: 20100256146
    Abstract: The application relates to trisubstituted piperidines of the general formula (I) and their salts, preferably their pharmaceutically acceptable salts, in which R1, R2, R3 and X have the meanings explained in the description, a process for their preparation and the use of these compounds as medicines, especially as renin inhibitors.
    Type: Application
    Filed: October 17, 2008
    Publication date: October 7, 2010
    Inventors: Peter Herold, Vincenzo Tschinke, Dirk Behnke, Stjepan Jelakovic, Nathalie Jotterand, Robert Mah
  • Substituted piperidines as renin inhibitors
    Patent number: 7799779
    Abstract: Compounds of the general formula (I) in which the meanings of the substituents R1, R2, R3, R4, X, Z and n as stated in claim 1 have renin-inhibiting properties and can be used as medicines.
    Type: Grant
    Filed: March 30, 2006
    Date of Patent: September 21, 2010
    Assignee: Novartis AG
    Inventors: Peter Herold, Robert Mah, Vincenzo Tschinke, Dirk Behnke, Christiane Marti, Nathalie Jotterand, Stefan Stutz, Michael Quirmbach
  • 4-ARYL-BUTANE-1,3-DIAMIDES
    Publication number: 20100222396
    Abstract: The invention relates to compound of the formula I in which the substituents are as defined in the specification; in free form or in salt form; to its preparation, to its use as medicament and to medicaments comprising it.
    Type: Application
    Filed: January 28, 2010
    Publication date: September 2, 2010
    Applicant: Novartis AG
    Inventors: Dirk BEHNKE, Claudia Betschart, Simona Cotesta, Marc Gerspacher, Samuel Hintermann, Bernard Lucien Roy, Anette Von Matt, Jürgen Wagner
  • Process for preparing organic compounds
    Patent number: 7723550
    Abstract: Process for preparing a compound of the formula (I) in which R1 and R2 are each independently H, C1-C8-alkyl, halogen, polyhalo-C1-C8-alkoxy, polyhalo-C1-C8-alkyl, C1-C8-alkoxy, C1-C8-alkoxy-C1-C8-alkyl, or C1-C8-alkoxy-C1-C8-alkoxy, where R1 and R2 are not both H, and R3 is C1-C8-alkyl, which is characterized in that a) a compound of the formula (II) in which R1 and R2 are each as defined above and X is Br, I, triflate, toyslate or mesylate is reacted with prop-2-yn-1-ol to give the compound of the formula (III), b) the compound of the formula (III) is reacted with an alkyl-metal compound in which “alkyl” is as defined above for R3 to give a compound of the formula (I).
    Type: Grant
    Filed: November 8, 2007
    Date of Patent: May 25, 2010
    Assignee: Novartis AG
    Inventors: Peter Herold, Robert Mah, Stefan Stutz, Aleksandar Stojanovic, Isabelle Lyothier, Dirk Behnke
  • Substituted piperidines
    Patent number: 7687495
    Abstract: Substituted piperidines of formulae (I) and (II) with the substituent definitions as explained in the specification. The compounds are suitable in particular as renin inhibitors and are highly potent.
    Type: Grant
    Filed: March 14, 2008
    Date of Patent: March 30, 2010
    Assignee: Speedel Experimenta AG
    Inventors: Peter Herold, Robert Mah, Vincenzo Tschinke, Christiane Marti, Stefan Stutz, Stjepan Jelakovic, Zenon D. Konteatis, Jennifer L. Ludington, Michael Quirmbach, Aleksandar Stojanovic, Dirk Behnke, Frank Hollinger
  • 2,4,5-Substituted Piperidines as Renin Inhibitors
    Publication number: 20100029628
    Abstract: SP-P2140 ATE-132—Abstract Novel substituted piperidines of the general formula (I) and (II) with the substituent definitions as explained in detail in the description are described. The compounds are suitable in particular as renin inhibitors and are highly potent.
    Type: Application
    Filed: March 30, 2006
    Publication date: February 4, 2010
    Inventors: Peter Herold, Robert Mah, Vincenzo Tschinke, Christiane Marti, Stefan Stutz, Stjepan Jelakovic, Zenon D. Konteatis, Jennifer L. Ludington, Michael Quirmbach, Aleksandar Stojanovic, Dirk Behnke, Frank Hollinger
  • Substituted Piperidines as Renin Inhibitors
    Publication number: 20090306064
    Abstract: Compounds of the general formula (I) in which the meanings of the substituents R1, R2, R3, R4, X, Z and n as stated in claim 1 have renin-inhibiting properties and can be used as medicines.
    Type: Application
    Filed: March 30, 2006
    Publication date: December 10, 2009
    Inventors: Peter Herold, Robert Mah, Vincenzo Tschinke, Dirk Behnke, Christiane Marti, Nathalie Jotterand, Stefan Stutz, Michael Quirmbach
  • Substituted 4-phenyl piperidines for use as renin inhibitors
    Patent number: 7625893
    Abstract: Compounds of the general formula (I) and the salts thereof, preferably the pharmaceutically acceptable salts thereof; in which R1 is straight-chain C1-8-alkanoyloxy, straight-chain C1-8-alkoxy, straight-chain C1-8-alkoxy-straight-chain-C1-8-alkoxy, straight-chain C1-8-alkoxycarbonylamino, straight-chain C0-8-alkylcarbonylamino, optionally N-mono- or N,N-di-C1-8-alkylated amino or hydroxy or straight-chain omega-hydroxy-C1-8-alkyl.
    Type: Grant
    Filed: October 3, 2007
    Date of Patent: December 1, 2009
    Assignee: Speedel Experimenta AG
    Inventors: Peter Herold, Robert Mah, Stefan Stutz, Vincenzo Tschinke, Aleksandar Stojanovic, Dirk Behnke, Nathalie Jotterand, Stjepan Jelakovic
  • 3,4,5-Substituted Piperidines as Renin Inhibitors
    Publication number: 20090270380
    Abstract: The application relates to novel substituted piperidines of the general formula (II) in which R1, R2?, R2?, R4?, X, Z, m and n have the meanings defined in the description, to a process for the preparation thereof and to the use of these compounds as medicines, especially as renin inhibitors.
    Type: Application
    Filed: March 30, 2006
    Publication date: October 29, 2009
    Inventors: Peter Herold, Robert Mah, Vincenzo Tschinke, Nathalie Jotterand, Dirk Behnke, Aleksandar Stojanovic, Stefan Stuz, Michael Quirmbach, Stjepan Jelakovic
  • Process for Preparing organic compounds
    Publication number: 20090105503
    Abstract: Process for preparing a compound of the formula (I) in which R1 and R2 are each independently H, C1-C8-alkyl, halogen, polyhalo-C1-C8-alkoxy, polyhalo-C1-C8-alkyl, C1-C8-alkoxy, C1-C8-alkoxy-C1-C8-alkyl, or C1-C8-alkoxy-C1-C8-alkoxy, where R1 and R2 are not both H, and R3 is C1-C8-alkyl, which is characterized in that a) a compound of the formula (II) in which R1 and R2 are each as defined above and X is Br, I, triflate, toyslate or mesylate is reacted with prop-2-yn-1-ol to give the compound of the formula (III), b) the compound of the formula (III) is reacted with an alkyl-metal compound in which “alkyl” is as defined above for R3 to give a compound of the formula (I).
    Type: Application
    Filed: November 8, 2007
    Publication date: April 23, 2009
    Inventors: Peter Herold, Robert Mah, Stefan Stutz, Aleksandar Stojanovic, Isabelle Lyothier, Dirk Behnke
  • Process for the Stereoselective Preparation of Alcohols From Alpha, Beta-Insaturated Compounds
    Publication number: 20090088576
    Abstract: A process for the synthesis of an alcohol of formula (I), using as intermediate a compound of formula (V).
    Type: Application
    Filed: January 29, 2007
    Publication date: April 2, 2009
    Inventors: Peter Herold, Stefan Stutz, Robert Mah, Aleksandar Stojanovic, Isabelle Lyothier, Dirk Behnke, Felix Spindler, Erhard Bappert
  • Substituted 4-Phenyl Piperidines for Use as Renin Inhibitors
    Publication number: 20090088426
    Abstract: Compounds of the general formula (I) and the salts thereof, preferably the pharmaceutically acceptable salts thereof; in which R1 is straight-chain C1-8-alkanoyloxy, straight-chain C1-8-alkoxy, straight-chain C1-8-alkoxy-straight-chain-C1-8-alkoxy, straight-chain C1-8-alkoxycarbonylamino, straight-chain C0-8-alkylcarbonylamino, optionally N-mono- or N,N-di-C1-8-alkylated amino or hydroxy or straight-chain omega-hydroxy-C1-8-alkyl.
    Type: Application
    Filed: October 3, 2007
    Publication date: April 2, 2009
    Inventors: Peter Herold, Robert Mah, Stefan Stutz, Vincenzo Tschinke, Aleksandar Stojanovic, Dirk Behnke, Nathalie Jotterand, Stjepan Jelakovic