Patents by Inventor Dirk de Waart

Dirk de Waart has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8513023
    Abstract: A method of determining the functional activity of the MRP2 and/or MRP3 efflux pathway of a human or animal subject was disclosed. The method comprises (i) determining the level of a bile acid derivative in the blood of said human or animal subject at a predetermined time interval after introducing an amount of the bile acid derivative into the subject, and (ii) using the determination obtained in step (i) to indicate the functional activity of the MRP2 and/or MRP3 efflux pathway of the subject.
    Type: Grant
    Filed: October 25, 2012
    Date of Patent: August 20, 2013
    Assignee: Norgine BV
    Inventors: Hans-Jürgen Gruss, Ronald Oude Elferink, Dirk De Waart, Bruno Stieger
  • Patent number: 8318504
    Abstract: In one aspect a method of determining the functional activity of the MRP2 and/or MRP3 efflux pathway of a human or animal subject, comprises: (i) determining the level of a bile acid derivative in the blood of said human or animal subject at a predetermined time interval after introducing an amount of the bile acid derivative into the subject; and (ii) using the determination obtained in step (i) to indicate the functional activity of the MRP2 and/or MRP3 efflux pathway of the subject.
    Type: Grant
    Filed: May 14, 2009
    Date of Patent: November 27, 2012
    Assignee: Norgine BV
    Inventors: Hans-Jürgen Gruss, Ronald Oude Elferink, Dirk de Waart, Bruno Stieger
  • Publication number: 20090286277
    Abstract: In one aspect a method of determining the functional activity of the MRP2 and/or MRP3 efflux pathway of a human or animal subject, comprises: (i) determining the level of a bile acid derivative in the blood of said human or animal subject at a predetermined time interval after introducing an amount of the bile acid derivative into the subject; and (ii) using the determination obtained in step (i) to indicate the functional activity of the MRP2 and/or MRP3 efflux pathway of the subject.
    Type: Application
    Filed: May 14, 2009
    Publication date: November 19, 2009
    Applicant: Norgine BV
    Inventors: Hans-Jurgen Gruss, Ronald Oude Elferink, Dirk de Waart, Bruno Stieger