Patents by Inventor Dirk Denzer
Dirk Denzer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6034115Abstract: The indolyl-substituted phenylacetic acid derivatives are prepared by reacting the corresponding phenylacetic acids with the required amines. The indolyl-substituted phenylacetic acid derivatives are suitable as active compounds in medicaments, in particular in antiarteriosclerotic medicaments.Type: GrantFiled: December 9, 1996Date of Patent: March 7, 2000Assignee: Bayer AktiengesellschaftInventors: Richard Connell, Siegfried Goldmann, Ulrich Muller, Stefan Lohmer, Hilmar Bischoff, Dirk Denzer, Rudi Grutzmann, Stefan Wohlfeil
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Patent number: 6025378Abstract: The bicyclic heterocyclic compounds are prepared by reaction of correspondingly substituted carboxylic acids with amines, in particular with phenylglycinolamine. The bicyclic heterocyclic compounds according to the invention are suitable as active compounds in medicaments, in particular in medicaments having an antiatherosclerotic action.Type: GrantFiled: June 18, 1998Date of Patent: February 15, 2000Assignee: Bayer AktiengesellschaftInventors: Richard Connell, Siegfried Goldmann, Ulrich Muller, Stefan Lohmer, Hilmar Bischoff, Dirk Denzer, Rudi Grutzmann, Stefan Wohlfeil
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Patent number: 5935984Abstract: The heterocyclically substituted phenylglycinolamides are obtained by reaction of heterocyclically substituted phenylacetic acids with appropriate phenylglycinols. The heterocyclically substituted phenylglycinolamides are suitable as active compounds in medicaments, in particular in antiatherosclerotically active medicaments.Type: GrantFiled: April 10, 1997Date of Patent: August 10, 1999Assignee: Bayer AktiengesellschaftInventors: Siegfried Goldmann, Ulrich Muller, Richard Connell, Hilmar Bischoff, Dirk Denzer, Rudi Grutzmann, Martin Beuck
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Patent number: 5935983Abstract: The phenylcyclohexylcarboxamides, some of which are known, are suitable as active compounds in medicaments, in particular in medicaments for the treatment of restenosis.Type: GrantFiled: October 24, 1997Date of Patent: August 10, 1999Assignee: Bayer AktiengesellschaftInventors: Matthias Muller-Gliemann, Ulrich Muller, Martin Beuck, Siegfried Zaiss, Christoph Gerdes, Anke Domdey-Bette, Rudi Grutzmann, Stefan Lohmer, Stefan Wohlfeil, Ozkan Yalkinoglu, James Elting, Dirk Denzer
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Patent number: 5925646Abstract: The heterocyclic aryl-, alkyl- and cycloalkylacetamides are prepared by reacting the appropriately substituted acetic acids with amines, if appropriate in complexed form. The heterocyclic aryl-, alkyl- and cycloalkylacetamides can be used as active compounds in medicaments, in particular in antiatherosclerotic medicaments.Type: GrantFiled: January 16, 1998Date of Patent: July 20, 1999Assignee: Bayer AktiengesellschaftInventors: Richard Connell, Siegfried Goldmann, Ulrich Muller, Martin Beuck, Hilmar Bischoff, Dirk Denzer, Rudi Grutzmann, Stefan Wohlfeil
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Patent number: 5892114Abstract: The hetero-linked phenylglycinolamides are prepared by reaction of the corresponding hetero-linked phenylacetic acids with appropriate phenylglycinols. The hetero-linked phenylglycinolamides are suitable as active compounds in medicaments.Type: GrantFiled: April 10, 1997Date of Patent: April 6, 1999Assignee: Bayer AktiengesellschaftInventors: Siegfried Goldmann, Ulrich Muller, Richard Connell, Hilmar Bischoff, Dirk Denzer, Rudi Grutzmann, Martin Beuck
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Patent number: 5849751Abstract: Amides and sulphonamides of benzylamines having heterocyclic substituents are prepared by first converting the corresponding carboxylic acids into the corresponding amines and then substituting these on the amine nitrogen in a corresponding manner. The new amides and sulphonamides of benzylamines having heterocyclic substituents can be used as active compounds in medicaments, in particular in antiatherosclerotic medicaments.Type: GrantFiled: July 3, 1996Date of Patent: December 15, 1998Assignee: Bayer AktiengesellschaftInventors: Ulrich Muller, Richard Connell, Hilmar Bischoff, Dirk Denzer, Stefan Lohmer, Stefan Wohlfeil, Rudi Grutzmann
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Patent number: 5811429Abstract: The bicyclic heterocyclic compounds are prepared by reaction of correspondingly substituted carboxylic acids with amines, in particular with phenylglycinolamine. The bicyclic heterocyclic compounds according to the invention are suitable as active compounds in medicaments, in particular in medicaments having an antiatherosclerotic action.Type: GrantFiled: December 9, 1996Date of Patent: September 22, 1998Assignee: Bayer AktiengesellschaftInventors: Richard Connell, Siegfried Goldmann, Ulrich Muller, Stefan Lohmer, Hilmar Bischoff, Dirk Denzer, Rudi Grutzmann, Stefan Wohlfeil
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Patent number: 5786361Abstract: Compounds of the formula (I): ##STR1## are prepared by reaction of the phenylacetic acid derivatives substituted by the appropriate heterocycles, optionally in an activated form, with phenylglycinols. The compounds are suitable as active compounds in medicaments, in particular in medicaments having antiatherosclerotic activity.Type: GrantFiled: April 11, 1997Date of Patent: July 28, 1998Assignee: Bayer AktiengesellschaftInventors: Ulrich Muller, Peter Eckenberg, Rudi Grutzmann, Hilmar Bischoff, Dirk Denzer, Ulrich Nielsch
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Patent number: 5750783Abstract: Benzyloxy-substituted phenylglycinolamides are prepared by reaction of benzyloxy-substituted phenylacetic acids with phenylglycinols. The benzyloxy-substituted phenylglycinolamides are suitable as active compounds in medicaments, in particular in medicaments for the treatment of atherosclerosis.Type: GrantFiled: April 10, 1997Date of Patent: May 12, 1998Assignee: Bayer AktiengesellschaftInventors: Siegfried Goldmann, Ulrich Muller, Richard Connell, Hilmar Bischoff, Dirk Denzer, Rudi Grutzmann, Martin Beuck
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Patent number: 5747505Abstract: The heterocyclic aryl-, alkyl- and cycloalklacetamides are prepared by reacting the appropriately substituted acetic acids with amines, if appropriate in complexed form. The heterocyclic aryl-, alkyl- and cycloalkylacetamides can be used as active compounds in medicaments, in particular in antiatherosclerotic medicaments.Type: GrantFiled: September 20, 1996Date of Patent: May 5, 1998Assignee: Bayer AktiengesellschaftInventors: Richard Connell, Siegfried Goldmann, Ulrich Muller, Martin Beuck, Hilmar Bischoff, Dirk Denzer, Rudi Grutzmann, Stefan Wohlfeil
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Patent number: 5714494Abstract: Substituted xanthines of formula ##STR1## in which A represents a radical of the formula ##STR2## in which R.sup.3, R.sup.4, R.sup.6 and R.sup.7 denote hydrogen, cycloalkyl, aryl having 6 to 10 carbon atoms, or denote straight-chain of branched alkyl or alkenyl, each of which is optionally substituted; T, V, X and Y are identical or different and denote an oxygen or sulphur atom; R.sup.5 and R.sup.8 are identical or different and denote hydrogen, halogen, cycloalkyl having 3 to 8 carbon atoms or straight-chain or branched alkyl or alkenyl in each case having up to 8 carbon atoms, optionally substituted or R.sup.5 and R.sup.8 denote aryl having 6 to 10 carbon atoms or a 5- to 7-membered aromatic, optionally benzo-fused heterocycle having up to 3 heteroatoms S, N and/or O, each of which is optionally substituted; L represents an oxygen or sulphur atom; R.sup.2 represents mercapto, hydroxyl, straight-chain or branched alkoxy having up to 8 carbon atoms or the group of the formula ##STR3## in which R.sup.Type: GrantFiled: September 18, 1996Date of Patent: February 3, 1998Assignee: Bayer AktiengesellschaftInventors: Richard Connell, Siegfried Goldmann, Ulrich Muller, Stefan Lohmer, Hilmar Bischoff, Dirk Denzer, Rudi Grutzmann, Stefan Wohlfeil
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Patent number: 5712296Abstract: Substituted pyridines and 2-oxo-1,2-dihydropyridines are prepared by reaction of correspondingly substituted halogenobenzenes with tetrazolylboronic acids. The substituted pyridines and 2-oxo-1,2-dihydropyridines according to the invention can be employed as active compounds in medicaments, in particular for the treatment of arterial hypertension and atherosclerosis.Type: GrantFiled: October 27, 1995Date of Patent: January 27, 1998Assignee: Bayer AktiengesellschaftInventors: Peter Fey, Jurgen Dressel, Rudolf Hanko, Walter Hubsch, Thomas Kramer, Ulrich Muller, Matthias Muller-Gliemann, Martin Beuck, Hilmar Bischoff, Stefan Wohlfeil, Dirk Denzer, Stanislav Kazda, Johannes-Peter Stasch, Andreas Knorr, Siegfried Zaiss
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Patent number: 5693650Abstract: 4-(Quinolin-2-yl-methoxy)-phenyl-acetic acid derivatives are prepared by reacting quinoline-methoxy-phenyl-acetic acids with the corresponding glycinol derivatives, if appropriate with activation of the carboxylic acid function. The new compounds are suitable as active compounds in medicaments, in particular in antiatherosclerotic medicaments.Type: GrantFiled: December 5, 1995Date of Patent: December 2, 1997Assignee: Bayer AktiengesellschaftInventors: Ulrich Muller, Richard Connell, Siegfried Goldmann, Klaus-Helmut Mohrs, Rolf Angerbauer, Matthias Muller-Gliemann, Ulrich Niewohner, Rudi Grutzmann, Martin Beuck, Stefan Wohlfeil, Hilmar Bischoff, Dirk Denzer
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Patent number: 5691337Abstract: Oxy-phenyl-(phenyl)glycinolamides with heterocyclic substituents are prepared by reaction of the corresponding oxyphenylcarboxylic acids with heterocyclic substituents with phenylglycinol. The new substances are suitable as active compounds in medicaments, in particular in agents having an antiatherosclerotic action.Type: GrantFiled: January 13, 1997Date of Patent: November 25, 1997Assignee: Bayer AktiengesellschaftInventors: Ulrich Muller, Richard Connell, Siegfried Goldmann, Klaus-Helmut Mohrs, Siegfried Raddatz, Michael Matzke, Rudi Grutzmann, Martin Beuck, Stefan Wohlfeil, Hilmar Bischoff, Dirk Denzer
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Patent number: 5684014Abstract: Cycloalkano-indole and -azaindole derivatives are prepared by reaction of appropriately substituted carboxylic acids with amines. The cycloalkano-indole and -azaindole derivatives are suitable as active compounds for medicaments, preferably antiatherosclerotic medicaments.Type: GrantFiled: September 28, 1995Date of Patent: November 4, 1997Assignee: Bayer AktiengesellschaftInventors: Ulrich Muller, Richard Connell, Siegfried Goldmann, Rudi Grutzmann, Martin Beuck, Hilmar Bischoff, Dirk Denzer, Anke Domdey-Bette, Stefan Wohlfeil
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Patent number: 5646162Abstract: Oxy-phenyl-(phenyl)gycinolamides with heterocyclic substituents are prepared by reaction of the corresponding oxyphenylcarboxylic acids with heterocyclic substituents with phenylglycinol. The new substances are suitable as active compounds in medicaments, in particular in agents having an antiatherosclerotic action.Type: GrantFiled: December 1, 1995Date of Patent: July 8, 1997Assignee: Bayer AktiengesellschaftInventors: Ulrich Muller, Richard Connell, Siegfried Goldmann, Klaus-Helmut Mohrs, Siegfried Raddatz, Michael Matzke, Rudi Grutzmann, Martin Beuck, Stefan Wohlfeil, Hilmar Bischoff, Dirk Denzer
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Patent number: 5607962Abstract: Substituted indole derivatives are prepared by reacting appropriate carboxylic acids, if appropriate in the presence of auxiliaries, with appropriate amines. The substituted indole derivatives are suitable as active compounds in medicaments, in particular in medicaments for the treatment of arteriosclerosis and restenosis.Type: GrantFiled: January 25, 1996Date of Patent: March 4, 1997Assignee: Bayer AktiengesellschaftInventors: Matthias M uller-Gliemann, Ulrich M uller, Martin Beuck, Siegfried Zaiss, Christoph Gerdes, Anke Domdey-Bette, Rudi Gr utzmann, Stefan Lohmer, Stefan Wohlfeil, Ozkan Yalkinoglu, James Elting, Dirk Denzer
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Patent number: 5594010Abstract: The substituted monopyridyl and bipyridyl derivatives are prepared by reacting substituted pyridine halides with phenylboronic acids. They are suitable for use as active compounds in medicaments for treating arterial hypertension and atherosclerosis.Type: GrantFiled: June 17, 1994Date of Patent: January 14, 1997Assignee: Bayer AktiengesellschaftInventors: Peter Fey, Thomas Kr amer, J urgen Dressel, Rudolf Hanko, Walter H ubsch, Ulrich M uller, Matthias M uller-Gliemann, Martin Beuck, Hilmar Bischoff, Stefan Wohlfeil, Dirk Denzer, Stanislav Kazda, Johannes-Peter Stasch, Andreas Knorr, Siegfried Zaiss
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Patent number: 5530016Abstract: Novel substituted 2,4-imidazolidinediones are prepared either by reaction of .alpha.-aminocarboxylic acid derivatives with appropriately substituted biphenylmethyl halides and subsequent cyclization with isocyanates or by reaction of N-benzyl-substituted .alpha.-aminocarboxylic acid derivatives with tetrazolylphenylboronic acids or by reaction of sulphonyl-substituted benzyl halides with .alpha.-aminocarboxylic acid derivatives and subsequent cyclization with isocyanates. The compounds according to the invention can be employed as active compounds in medicaments, preferably for the treatment of arterial hypertension and arteriosclerosis.Type: GrantFiled: May 18, 1994Date of Patent: June 25, 1996Assignee: Bayer AktiengesellschaftInventors: Thomas Kramer, Rudolf Hanko, Jurgen Dressel, Peter Fey, Walter Hubsch, Ulrich Muller, Matthias Muller-Gliemann, Martin Beuck, Hilmar Bischoff, Stefan Wohlfeil, Dirk Denzer, Stanislav Kazda, Johannes-Peter Stasch, Andreas Knorr, Siegfried Zaiss