Abstract: An intelligent oral appliance (100) comprises maxillary and mandibular appliances (102, 104), an electromagnetic clamp (106, 108), first and second sensors (110, 112), a timer (114), and a controller (116). The electromagnetic clamp (106, 108) couples between the maxillary (102) and mandibular (104) appliances and operates according to engaged and disengaged clamping actions. The first sensor (110) detects a body/head position/orientation. The second sensor (112) detects a characteristic of sleep disordered breathing, snoring intensity, or combination thereof. The timer (114) provides preset time intervals.

Abstract: According to an aspect, there is provided a training device for use in an inhaler, the training device comprising a body that is configured to be received at a first position in a housing of an inhaler, wherein the body comprises an interface arranged to connect to a canister interface in the housing of the inhaler; an electrical circuit configured to perform one or more functions; and a circuit triggering mechanism that comprises a switch for enabling the electrical circuit to perform the one or more functions when the switch is closed, wherein the circuit triggering mechanism is configured such that the switch is closed when the body is pressed from the first position towards the canister interface and into a second position in the housing of the inhaler.

Abstract: A method of managing and reducing the recall frequency of disturbing dreams comprises monitoring (100; 200; 300) electroencephalography (EEG) activity of a subject, detecting (102; 206; 302) an indicator of a disturbing dream of the subject based on power in a theta or alpha band of the EEG activity of the subject, and providing stimulation (104; 212; 308) to the subject at a frequency lower than the theta band in response to detecting the indicator of the disturbing dream.

Abstract: A method of optimizing pharmacotherapy includes monitoring one or more characteristics of a patient associated with a condition of the patient and evaluating a baseline severity of the condition of the patient, recommending a selected therapy to the patient based on a therapy efficacy-risk map, evaluating an actual severity of the condition of the patient, evaluating an efficacy of the selected therapy, evaluating a risk score of the selected therapy, and updating the therapy efficacy-risk map based on the evaluated efficacy and risk score of the selected therapy.

Abstract: A system and method for providing a recommendation of an insomnia therapy leverage various metrics including personal health profile, 24/7 biometrics, behavioral information, and environmental stressors to predict insomnia severity, to build a personalized severity and type insomnia therapy map ranked by historic therapy efficacy, to provide a contextualized personalized therapy recommendation, and to optimize the insomnia therapy.

Abstract: A method of optimizing treatment of a condition includes monitoring one or more characteristics of a patient associated with a condition of the patient, predicting a severity of the condition of the patient, recommending a selected therapy to the patient based on a therapy-severity map, evaluating an actual severity of the condition of the patient, evaluating an efficacy of the selected therapy, and updating the therapy-severity map based on the evaluated efficacy of the therapy.

Abstract: An accessory (50,80) adapted to be used with a breath actuated inhaler (10), the breath actuated inhaler (10) comprising an air inlet (19), an outlet (20) for delivering medicament and a trigger mechanism (30) for triggering the delivery of a dose of the medicament in response to a flow (40) between the air inlet (19) and the outlet (20), wherein the accessory comprises: a pressure assist unit (52, 54) for application to the air inlet, comprising an assist chamber (52) for holding a volume of air and a mechanical release system (54, 70) for expelling air from the assist chamber to the air inlet, at a rate sufficient to trigger the trigger mechanism. Hence, it has an assist chamber for holding a volume of air and a mechanical release system for expelling air from the assist chamber to the air inlet, at a rate sufficient to trigger a dose trigger mechanism of the breath actuated inhaler.

Abstract: The present invention relates to a feedback for inhalation. In order to further improve feedback and instructions to further support the correct use of an inhaler, a feedback apparatus (10) for inhalation is provided that comprises an inhaler interface (11), a processor (14), a feedback device (16), and a feature assigner (13). The inhaler interface is configured to temporarily attach the feedback apparatus to an inhalation apparatus. The feedback device is configured to provide a feedback to the user to aid in inhalation with the inhalation apparatus. The feature assigner is configured to identify a type of a predetermined feature of the attached inhalation apparatus, and the feedback device is configured to provide the feedback in dependency of the identified type of feature to instruct the user to adjust inhalation maneuver adapted to the attached inhalation apparatus.

Abstract: An apparatus and method involve not just comparing a patient's recovery but improving predications by grouping the patient into a phenotype to trend the patient's rate of progress compared to existing phenotype clusters to predict, based on a comparison of rate of progress of decline, and assess in order to benefit in the improvement of allocation and timing of future resource needs, including the economic impact.

Abstract: There is provided a control unit (100) for use with a respiratory assist device (102) that assists a subject (104) with respiration. The control unit (100) configured to detect a time at which delivery of an inhalable therapy to the subject (104) is manually triggered on an inhalable therapy device (106). The control unit (100) is also configured to detect whether the subject (104) has fallen asleep and, on detecting that the subject (104) has fallen asleep, control the inhalable therapy device (106) to automatically trigger delivery of the inhalable therapy to the subject (104) at least a predefined length of time following the detected time at which delivery of the inhalable therapy to the subject (104) is manually triggered.

Abstract: Systems and methods for delivering therapy and/or medicament to a subject use one or more sensors to generate signals that represent characteristics of ultrasonic energy emitted during the use of respiratory medicament delivery devices. Parameters based on these signals indicate energy amplitude in one or more frequency ranges. Such parameters can be used to characterize the emitted ultrasonic energy and control and/or monitor device operation and/or patient adherence.

Abstract: An assembly for use in a liquid droplet apparatus comprises a vibrating element (201), an aperture plate (205) and a vibrating platform (203). The vibrating platform is positioned between the vibrating element and the aperture plate for conveying vibrations from the vibrating element to the aperture plate. The vibrating platform (203) is structured such that the aperture plate (205) is located within a cavity (202) formed in the vibrating platform.

Abstract: Systems and methods for delivering medicament to a subject use one or more sensors to generate signals that represent characteristics of the ultrasonic energy emitted into or by a respiratory medicament delivery device. Parameters based on these signals indicate energy amplitude in one or more frequency ranges. Such parameters can be used to determine respiratory parameters, patient adherence, and/or other parameters.

Abstract: According to an aspect, there is provided a training device for use in an inhaler, the training device comprising a body that is configured to be received at a first position in a housing of an inhaler, wherein the body comprises an interface arranged to connect to a canister interface in the housing of the inhaler; an electrical circuit configured to perform one or more functions; and a circuit triggering mechanism that comprises a switch for enabling the electrical circuit to perform the one or more functions when the switch is closed, wherein the circuit triggering mechanism is configured such that the switch is closed when the body is pressed from the first position towards the canister interface and into a second position in the housing of the inhaler.

Abstract: The present disclosure pertains to a system and method for monitoring usage of a respiratory medicament delivery device. Regular use of a respiratory medicament delivery device at intervals prescribed by a doctor may be critical to a subject's health. The system described herein is configured to monitor usage of a respiratory medicament delivery device such that manual tracking of a patient's adherence to a dosage plan by a doctor, for example, is not required. Monitoring usage of the medicament device delivery device may allow the doctor to judge the adherence of the subject to the dosage plan and encourage increased adherence. Improved adherence by the subject may result in improvement in the condition of the subject and economic benefits including reducing costs associated with re-hospitalization after discharge. In some embodiments, the system comprises a medicament delivery device and a usage event monitoring device.

Abstract: The present invention relates to aerosol generation. In order to provide an improved way of protecting and sealing of a vibrating element, an aerosol generator device (10) for a nebulizer is provided. The aerosol generator device comprises a base structure (12), a mesh (14) with a plurality of apertures, and a vibrating element (16). The vibrating element is a piezo-element arranged to generate an oscillating movement. The piezo-element is connected to the base structure to transfer the oscillating movement as vibrational movement to the base structure. Further, the mesh is mounted to the base structure, and the vibrational movement is transferred to the mesh in order to generate a plurality of small droplets to form an aerosol when supplied by a fluid. An encapsulation (18) of the piezo-element is provided to provide a sealing of the piezo-element.

Abstract: The present invention relates to a feedback for inhalation. In order to further improve feedback and instructions to further support the correct use of an inhaler, a feedback apparatus (10) for inhalation is provided that comprises an inhaler interface (11), a processor (14), a feedback device (16), and a feature assigner (13). The inhaler interface is configured to temporarily attach the feedback apparatus to an inhalation apparatus. The feedback device is configured to provide a feedback to the user to aid in inhalation with the inhalation apparatus. The feature assigner is configured to identify a type of a predetermined feature of the attached inhalation apparatus, and the feedback device is configured to provide the feedback in dependency of the identified type of feature to instruct the user to adjust inhalation maneuver adapted to the attached inhalation apparatus.

Abstract: A method of providing airway clearance therapy to a patient includes receiving an expiratory airstream from the patient in a chamber, causing a back pressure to be created in the chamber (10) in response to receiving the expiratory airstream, causing a one-way valve, such as a magnetic duckbill valve (26), located downstream of the chamber to open only in response to the back pressure being at least equal to a certain predetermined level, causing a vibratory effect to be generated downstream of the one-way valve, for example using a vibratory ball check valve (32), when the one-way valve is open and in response to the expiratory air-stream passing therethrough, and delivering a percussive sensation to the patient through the chamber responsive to the vibratory effect.

Abstract: A monitoring device includes a housing that is constructed and arranged to be removably attached to a drug delivery device for an inhaled drug. A color detector is operatively associated with the housing and constructed and arranged to detect an identifying color of at least a portion of the drug delivery device when the housing is attached to the drug delivery device and to output color information for use by a processor to, based on the detected color, identify information about the inhaled drug.

Abstract: An assembly for use in a liquid droplet apparatus comprises a vibrating element (11), an aperture plate (15) and a vibrating platform (13). The vibrating platform (13) is positioned between the vibrating element (11) and the aperture plate (15) for conveying vibrations from the vibrating element (11) to the aperture plate (15). The vibrating platform comprises a first portion (13a) coupled to the vibrating element, a second portion (13b) coupled to the aperture plate, and wherein the first and second portions of the vibrating platform are detachably connected to one another.