Abstract: The present invention provides devices and methods for stabilizing bicarbonate-based solutions for peritoneal dialysis or hemofiltration. The bicarbonate-based solutions of the present invention are formulated and stored in at least two parts—an alkaline bicarbonate concentrate and an acidic concentrate. The alkaline bicarbonate concentrate is adjusted to have a pH of about 8.6 to 10.0. The acidic concentrate is adjusted to have a stable, acidic pH ranging from about 1.0 to 3.0. Upon mixing, although some variation in the pH of the mixed bicarbonate solution exists, the inventors have discovered that with the appropriate selection of the parameters of the concentrates, the pH of the mixed solution is always within an acceptable physiological range.

Abstract: A system and a method are provided for admixing solutions. The system includes containers separately accessible by one or more pumps for mixture of the solutions in a container immediately before administration to a peritoneal cavity of a patient. Alternatively, the system and method allow for direct administration of the mixed solution to the peritoneal cavity of a patient without intermediate mixing thereof. The solutions may be mixed in predetermined ratios as input to the system prior to delivery.

Abstract: A container system for containing and preserving gas generating solutions such as bicarbonate-containing solutions is provided. The system includes an outer container or barrier that is gas impermeable. The system also includes an indicator for visually indicating when gas has been permitted to leak or escape from the outer container thereby changing the physical characteristics of the gas generating solution.

Abstract: A multiple chamber container for mixing and administering a plurality of products. The container has at least two chambers separated by a seal line. A frangible connector is situated between the two chambers for mixing the products contained within the chambers as desired. Each chamber has at least one port for filling of product into the chamber. The ports are located on the same exterior side of the container such that the chambers can be filled without folding the bag and by using existing filling equipment.

Abstract: A multiple chamber container for mixing and administering a plurality of products. The container has at least two chambers separated by a seal line. A frangible connector is situated between the two chambers for mixing the products contained within the chambers as desired. Each chamber has at least one port for filling of product into the chamber. The ports are located on the same exterior side of the container such that the chambers can be filled without folding the bag and by using existing filling equipment.

Abstract: A method and device for stabilizing and storing bicarbonate solutions is provided. In an embodiment, a device is provided having a container and carbon-dioxide generating substances that include a solid material which upon contact with water generates carbon-dioxide gas. The device may be packaged together with the bicarbonate or in a separate overpouch. The present invention also provides a method for the stabilization of bicarbonate solutions utilizing a means that generates high pressure carbon dioxide.

Abstract: A peritoneal dialysis solution buffered with L-histidine to a pH of at least 6.5. An apparatus and method for utilizing the solution is also disclosed.