Abstract: The invention is based on the finding that endoplasmic reticulum (ER) stress signalling is associated with the pathogenesis of liver disorders such fatty liver, cirrhosis and hepatocellular carcinoma (HCC), and others. The invention identifies novel targets for liver disease therapy which are involved in ER stress signalling, and thereby pertains to compounds and compositions for medical uses, screening approaches to identify therapeutics as well as diagnostic approaches for the identification of disorders or the stratification of certain liver disease patient groups. The invention also pertains to the use of immune checkpoint inhibitors in combination with the compounds or compositions and/or in the treatment of endoplasmic reticulum (ER) stress signalling induced liver cancers.

Abstract: The invention relates to acetylcholine-producing microorganisms for use in the prevention and/or treatment of intestinal diseases, and/or reduction of risks of intestinal diseases, and/or improvement of intestinal health as well as promoting healthy gut flora. The acetylcholine-producing microorganisms may be provided as a pharmaceutical dosage form or as additive to functional food or food supplemental products. Also encompassed is a method for the production of acetylcholine by use of Lactobacilli. Further the invention refers to microbially produced acetylcholine for use in the treatment and/or prevention of intestinal diseases.

Abstract: The invention relates to acetylcholine-producing microorganisms for use in the prevention and/or treatment of intestinal diseases, and/or reduction of risks of intestinal diseases, and/or improvement of intestinal health as well as promoting healthy gut flora. The acetylcholine-producing microorganisms may be provided as a pharmaceutical dosage form or as additive to functional food or food supplemental products. Also encompassed is a method for the production of acetylcholine by use of Lactobacilli. Further the invention refers to microbially produced acetylcholine for use in the treatment and/or prevention of intestinal diseases.

Abstract: The invention relates to acetylcholine-producing microorganisms for use in the prevention and/or treatment of intestinal diseases, and/or reduction of risks of intestinal diseases, and/or improvement of intestinal health as well as promoting healthy gut flora. The acetylcholine-producing microorganisms may be provided as a pharmaceutical dosage form or as additive to functional food or food supplemental products. Also encompassed is a method for the production of acetylcholine by use of Lactobacilli. Further the invention refers to microbially produced acetylcholine for use in the treatment and/or prevention of intestinal diseases.

Abstract: The invention relates to lactocepins and/or a functionally active fragment thereof for use in the prophylaxis and/or the treatment of a disease and to one or more lactocepin(s) and/or one or more functionally active fragment(s) thereof for use in the prophylaxis and/or treatment of IP-10-mediated inflammatory diseases.

Abstract: In a press installation including a press with at least one press station and a multi-station press between arranged at a distance from each other which is a non-integral multiple of the press station distance of the multi-stage press. The installation also includes a transport arrangement for moving workpieces from press station to press-station concurrently by a step corresponding to the distance between the press station of the multi-station press. To compensate for an increased distance between the press station of the press and the adjacent press station of the multi-station press a deposit stage is arranged between the press and the multi-station press and includes a movable support an which the workpiece removed from the press can be deposited and from which, after appropriate movement of the support in the transport direction, it can be picked up by the transport arrangement for placement in the adjacent press station of the multi-stage press.

Abstract: In a press installation including a press with at least one press station and a multi-station press between arranged at a distance from each other which is a non-integral multiple of the press station distance of the multi-stage press. The installation also includes a transport arrangement for moving workpieces from press station to press-station concurrently by a step corresponding to the distance between the press station of the multi-station press. To compensate for an increased distance between the press station of the press and the adjacent press station of the multi-station press a deposit stage is arranged between the press and the multi-station press and includes a movable support an which the workpiece removed from the press can be deposited and from which, after appropriate movement of the support in the transport direction, it can be picked up by the transport arrangement for placement in the adjacent press station of the multi-stage press.

Abstract: In a belt coil serving as a transmitter/receiver for recording body-internal values, a belt coil including at least one insulated conductor tape for placement around a human or animal body part carries conductors and a connecting structure for closing the belt and interconnecting the individual conductors into a coil, and the belt tape includes a resilient section in which also each conductor is longitudinally expandable, and the contacts structures of the connector members are arranged in a displaced fashion such that the end of one conductor is connected to the beginning of a next adjacent conductor when the connecting members are joined and the opposite ends of the outermost conductors are accessible.

Abstract: In a belt coil serving as a transmitter/receiver for recording body-internal values, a belt coil including at least one insulated conductor tape for placement around a human or animal body part carries conductors and a connecting structure for closing the belt and interconnecting the individual conductors into a coil, and the belt tape includes a resilient section in which also each conductor is longitudinally expandable, and the contacts structures of the connector members are arranged in a displaced fashion such that the end of one conductor is connected to the beginning of a next adjacent conductor when the connecting members are joined and the opposite ends of the outermost conductors are accessible.