Abstract: A healthcare organization/enterprise (HCO) process definition framework is provided that holistically defines processes and process structures for a generic HCO. The HCO framework addresses clinical, operational and financial performance excellence and maximization. This model may be utilized by consultants and HCO representatives working together to integrate the HCO framework into an existing model of a specific HCO to create a customized process model for a this specific HCO. The models may be developed utilizing a process management tool, a best practice and benchmark database and Siemens HCO reference model. The approach focuses, from the beginning, on implementing change, and thus change management is an integral part of the holistic approach.