Patents by Inventor Dirk Henning Lenz

Dirk Henning Lenz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds
    Patent number: 8183019
    Abstract: A process is disclosed for preparing (3R,4R)-3-hydroxy-4-hydroxymethylpyrrolidine, the compound of formula (I), or (3S,4S)-3-hydroxy-4-hydroxymethylpyrrolidine, the compound of formula (Ia) involving, as a key step, the enzyme-catalysed enantioselective hydrolysis of a racemic 3,4-trans-disubstituted pyrrolidinone compound of formula (II).
    Type: Grant
    Filed: June 3, 2005
    Date of Patent: May 22, 2012
    Assignee: Industrial Research Limited
    Inventors: Dirk Henning Lenz, Jennifer Mary Mason, Keith Clinch, Gary Brian Evans, Peter Charles Tyler
  • Fused pyrimidines as inhibitors of nucleoside phosphorylases and nucleosidases
    Patent number: 8173662
    Abstract: The present invention relates to compounds of the general formula (I) which are inhibitors of purine muclioside phosphorylases (PNP), purine phosphoribosyltransferases (PPRT), 5?-methylthioadenosine phosphorylases (MTAP), 5?-methylthioadenosine mucliosidases (MTAN) and/or nucleoside hydrolases (NH). The invention also relates to the use of these compounds in the treatment of diseases and infections including cancer, bacterial infections, protozoal infections, and T-cell mediated disease and to pharmaceutical compositions containing the compounds.
    Type: Grant
    Filed: June 3, 2009
    Date of Patent: May 8, 2012
    Assignees: Industrial Research Limited, Albert Einstein College of Medicine of Yeshiva University
    Inventors: Gary Brian Evans, Richard Hubert Furneaux, Dirk Henning Lenz, Vern L. Schramm, Peter Charles Tyler, Olga Vladimirovna Zubkova
  • Inhibitors of nucleoside phoshorylases and nucleosidases
    Publication number: 20090239885
    Abstract: The present invention relates to compounds of the general formula (I) which are inhibitors of purine nucleoside phosphorylases (PNP), purine phosphoribosyltransferases (PPRT), 5?-methylthioadenosine phosphorylases (MTAP), 5?-methylthioadenosine nucleosidases (MTAN) and/or nucleoside hydrolases (NH). The invention also relates to the use of these compounds in the treatment of diseases and infections including cancer, bacterial infections, protozoal infections, and T-cell mediated disease and to pharmaceutical compositions containing the compounds.
    Type: Application
    Filed: June 3, 2009
    Publication date: September 24, 2009
    Inventors: Gary Brian Evans, Richard Hubert Furneax, Dirk Henning Lenz, Vern L. Schramm, Peter Charles Tyler, Olga Vladimirovna Zubkova
  • 5h-pyrrolo[3,2-D] pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases
    Patent number: 7553839
    Abstract: The present invention relates to compounds of the general formula (I) which are inhibitors of purine muclioside phosphorylases (PNP), purine phosphoribosyltransferases (PPRT), 5?-methylthioadenosine phosphorylases (MTAP), 5?-methylthioadenosine mucliosidases (MTAN) and/or nucleoside hydrolases (NH). The invention also relates to the use of these compounds in the treatment of diseases and infections including cancer, bacterial infections, protozoal infections, and T-cell mediated disease and to pharmaceutical compositions containing the compounds.
    Type: Grant
    Filed: August 21, 2003
    Date of Patent: June 30, 2009
    Assignees: Industrial Research Limited, Albert Einstein College of Medicine of Yeshiva University
    Inventors: Gary Brian Evans, Richard Hubert Furneaux, Dirk Henning Lenz, Vern L. Schramm, Peter Charles Tyler, Olga Vladimirovna Zubkova
  • Method for Preparing 3-Hydroxy-4-Hydroxymethyl-Pyrrolidine Compounds
    Publication number: 20080280334
    Abstract: A process is disclosed for preparing (3R,4R)-3-hydroxy-4-hydroxymethylpyrrolidine, the compound of formula (I), or (3S,4S)-3-hydroxy-4-hydroxymethylpyrrolidine, the compound of formula (Ia) involving, as a key step, the enzyme-catalysed enantioselective hydrolysis of a racemic 3,4-trans-disubstituted pyrrolidinone compound of formula (II).
    Type: Application
    Filed: June 3, 2005
    Publication date: November 13, 2008
    Inventors: Dirk Henning Lenz, Jennifer Mary Mason, Keith Clinch, Gary Brian Evans, Peter Charles Tyler