Abstract: The present invention relates to compositions, methods, uses and kits for combination therapies involving immunotherapies, such as adaptive cell therapy, e.g., T cell therapy, and an oncolytic virus (particularly parvovirus H-1), for treating subjects with cancer. The T cell therapy includes cells that express recombinant receptors such as chimeric antigen receptors (CARs). In some embodiments, the cancer is a solid tumor or a hematological malignancy.

Abstract: A splitting unit for a single pair Ethernet (SPE) hybrid line includes an input connection element, a first output connection element, a second output connection element, and an active unit providing power and data at the second output connection element. The input connection element, the first output connection element, and the second output connection element transfer power and data. The active unit has a power sourcing equipment (PSE) connected to the input connection element and to at least one of the first output connection element and the second output connection element. The PSE taps power from a power line onto a data line.

Abstract: An insulation displacement contact has a tubular body extending along a longitudinal axis toward an open end. The tubular body has a pair of cutting edges at the open end. The tubular body has a pair of opposing side surfaces each having a slot extending to the open end and disposed between the cutting edges. The slot on one of the opposing side surfaces is a contacting slot and the slot on the other of the opposing side surfaces is a positioning slot. A first clear width of the contacting slot is less than a second clear width of the positioning slot.

Abstract: A housing assembly for a plier-operated insulation-displacement connector includes a first housing section and a second housing section. The first housing section and the second housing section are movable with respect to one another. Each of the first housing section and the second housing section has a top surface grippable by a jaw of a plier. The top surface of the first housing section has a concave area in a first direction. The top surface of the second housing section at least one of: has a concave area in the first direction, and is slidably arranged along the first direction with respect to the top surface of the first housing section.

Abstract: A system assists during execution of a sequence of cuttings in a tree, wherein, during a cutting sequence, a first cut in the tree is followed by a second cut in the tree At least a part of an ideal course of the second cut depends on at least a part of a course of the first cut. An identification device identifies at least the part of the course of the first cut in the tree. A precalculation device precalculates at least the part of the ideal course of the second cut in the tree based on the identified part of the course of the first cut. An output device outputs cutting information for executing the second cut based on the precalculated part of the ideal course of the second cut.

Abstract: A system assists during felling of a tree. A provision device provides a property of the tree and/or a property of an environment of the tree, identifies at least part of a course of a cut in the tree for felling the tree and/or identifies a position and/or an orientation of a cutting apparatus executing the cut. A determination device obtains felling information related to an ideal felling direction of the tree, compares the identified part of the course to an obtained part of an ideal course of a cut to be executed in the tree for felling the tree in the ideal felling direction, compares the identified position and/or the identified orientation of the cutting apparatus to an obtained ideal position and/or an obtained ideal orientation of the cutting apparatus, and obtains cutting information based on the comparison. An output device outputs the obtained felling information and cutting information.

Abstract: The present invention relates to artificial Antigen Presenting Cells (aAPCs) comprising artificial Antigen Presenting Molecules (aAPMs) and, in particular, comprising dimers of the aAPMs as well as to methods for producing aAPCs. The invention further relates to compositions comprising the aAPCs and to vectors encoding the aAPMs of the aAPCs. Embodiments of the invention have been particularly developed for use in assays for determining an antigen-specific T cell response or a plurality of antigen-specific T cell responses and will be described hereinafter with reference to this application. However, it will be appreciated that the invention is not limited to this particular field of use.

Abstract: The present invention relates to a method for color visualization and separation of a natural and medical image comprising pixels defined by color pixel vector a=[a1a2, a3] in a Cartesian color space (e.g. RGB), where the color pixel vector is represented by a pure quaternion q=+a1i+a2j+a3k with i,j, k satisfying: i2=j2=k2=ijk=?1, ij=?ji=k,jk=?kj=i, ki=?ik=j and the image is decomposed into q+ and q using the orthogonal 2D planes split concept according to: (formula (I)) wherein/and g are pure unit quaternions or f and g describe interactively determined or computed colors (s1, s2). The method allows not only visualizing and separating certain colors in a digital image in a rapid fashion, but also permits a flexible definition pertinent to the kind of colors that can be visualized or separated by defining the corresponding decompositions by means of pure unit quaternions/and g. Colors s1, s2 can be defined manually or computed automatically from the image.

Abstract: A contact arrangement for a connector includes a plurality of contact elements each extending from a first connection side to a second connection side. A plurality of first end sections of a first subset of the contact elements contact a plurality of external elements in a first plane at the first connection side and a plurality of first end sections of a second subset of the contact elements contact a plurality of external elements in a second plane at the first connection side. The second plane is parallel to and spaced from the first plane in a height direction. A plurality of intermediate sections of at least some of the contact elements lie in a single common plane.

Abstract: Described is an anti-HSV antibody or an antigen-binding fragment thereof for use in treating an acute infection of mucosal or epidermal tissue in a subject caused by HSV-1 or HSV-2 selected from the group consisting of Herpes simplex labialis, Herpes simplex genitalis, chronic or disseminated cutaneous herpes simplex infection, Herpes gladiatorum and Eczema herpeticum, wherein said antibody is to be topically administered as well as to a pharmaceutical composition comprising an effective amount of said antibody or antigen-binding fragment thereof and at least one pharmaceutically acceptable excipient.

Abstract: An insulation displacement contact has a tubular body extending along a longitudinal axis toward an open end. The tubular body has a pair of cutting edges at the open end. The tubular body has a pair of opposing side surfaces each having a slot extending to the open end and disposed between the cutting edges. The slot on one of the opposing side surfaces is a contacting slot and the slot on the other of the opposing side surfaces is a positioning slot. A first clear width of the contacting slot is less than a second clear width of the positioning slot.

Abstract: Described is an anti-HSV antibody or an antigen-binding fragment thereof for use in treating an acute infection of mucosal or epidermal tissue in a subject caused by HSV-1 or HSV-2 selected from the group consisting of Herpes simplex labialis, Herpes simplex genitalis, chronic or disseminated cutaneous herpes simplex infection, Herpes gladiatorum and Eczema herpeticum, wherein said antibody is to be topically administered as well as to a pharmaceutical composition comprising an effective amount of said antibody or antigen-binding fragment thereof and at least one pharmaceutically acceptable excipient.

Abstract: The present invention relates to a modified viral structural protein (VSP) as a tool for specifically targeting a chimeric antigen receptor (CAR) expressed on cells of the immune system. The modified VSPs can assemble into virus like particles (VLP). Exposed areas of the VSPs are modified to comprise in a region located atthe surface of a higher order structure, e.g. such as a capsomeric structure, a capsid, a VLP, a viral vector or a virus, a ligand specifically binding to a CAR (LCAR). The present invention thus, provides a modified VSP. The invention also relates to a nucleic acid encoding said VSP. Further, the invention relates to a capsomeric structure, a capsid, a VLP, a viral vector or a virus comprising at least one VSP. Further, the invention relates to a pharmaceutical composition comprising the VSP, the nucleic acid, the capsomeric structure, the capsid, the VLP, the viral vector or the virus comprising at least one VSP.

Abstract: The present invention relates to a method for color visualization and separation of a natural and medical image comprising pixels defined by color pixel vector a=[a1a2, a3] in a Cartesian color space (e.g. RGB), where the color pixel vector is represented by a pure quaternion q=+a1i+a2j+a3k with i,j, k satisfying: i2=i2=k2=ijk=?1, ij=?ji=k,jk=?kj=i, ki=?ik=j and the image is decomposed into q+ and q using the orthogonal 2D planes split concept according to: (formula (I)) wherein/and g are pure unit quaternions or f and g describe interactively determined or computed colors (s1, s2). The method allows not only visualizing and separating certain colors in a digital image in a rapid fashion, but also permits a flexible definition pertinent to the kind of colors that can be visualized or separated by defining the corresponding decompositions by means of pure unit quaternions/and g. Colors s1, s2 can be defined manually or computed automatically from the image.

Abstract: A system assists during execution of a sequence of cuttings in a tree, wherein, during a cutting sequence, a first cut in the tree is followed by a second cut in the tree At least a part of an ideal course of the second cut depends on at least a part of a course of the first cut. An identification device identifies at least the part of the course of the first cut in the tree. A precalculation device precalculates at least the part of the ideal course of the second cut in the tree based on the identified part of the course of the first cut. An output device outputs cutting information for executing the second cut based on the precalculated part of the ideal course of the second cut.

Abstract: A system assists during felling of a tree. A provision device provides a property of the tree and/or a property of an environment of the tree, identifies at least part of a course of a cut in the tree for felling the tree and/or identifies a position and/or an orientation of a cutting apparatus executing the cut. A determination device obtains felling information related to an ideal felling direction of the tree, compares the identified part of the course to an obtained part of an ideal course of a cut to be executed in the tree for felling the tree in the ideal felling direction, compares the identified position and/or the identified orientation of the cutting apparatus to an obtained ideal position and/or an obtained ideal orientation of the cutting apparatus, and obtains cutting information based on the comparison. An output device outputs the obtained felling information and cutting information.

Abstract: A method assists during felling of a tree. The method includes the steps of: providing a property of the tree and/or a property of an environment of the tree; obtaining felling information related to an ideal felling direction of the tree based on the provided property; and outputting the obtained felling information.

Abstract: A method assists during execution of a sequence of cuttings in a tree, wherein, during a cutting sequence, a first cut in the tree is followed by a second cut in the tree At least a part of an ideal course of the second cut depends on at least a part of a course of the first cut. The method includes the steps of: identifying at least the part of the course of the first cut in the tree; precalculating at least the part of the ideal course of the second cut in the tree based on the identified part of the course of the first cut; and outputting cutting information for executing the second cut based on the precalculated part of the ideal course of the second cut.

Abstract: A method obtains an orientation of at least one section of a felled tree. The method includes the steps of: treating the at least one section of the felled tree; identifying an alignment and/or a position during the treatment; obtaining orientation information related to the orientation of the at least one section of the felled tree based on the identified alignment and/or the identified position; and outputting the obtained orientation information.

Abstract: A method assists during execution of a sequence of cuttings in a tree, wherein, during a cutting sequence, a first cut in the tree is followed by a second cut in the tree At least a part of an ideal course of the second cut depends on at least a part of a course of the first cut. The method includes the steps of: identifying at least the part of the course of the first cut in the tree; precalculating at least the part of the ideal course of the second cut in the tree based on the identified part of the course of the first cut; and outputting cutting information for executing the second cut based on the precalculated part of the ideal course of the second cut.