Patents by Inventor Dirk J. Van Den Boom

Dirk J. Van Den Boom has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR NON-INVASIVE ASSESSMENT OF FETAL GENETIC VARIATIONS THAT FACTOR EXPERIMENTAL CONDITIONS
    Publication number: 20230279494
    Abstract: Provided herein are methods, processes and apparatuses for non-invasive assessment of genetic variations.
    Type: Application
    Filed: May 10, 2023
    Publication date: September 7, 2023
    Inventors: Cosmin DECIU, Mathias EHRICH, Dirk J. VAN DEN BOOM, Zeljko DZAKULA
  • Methods for non-invasive assessment of fetal genetic variations that factor experimental conditions
    Patent number: 11697849
    Abstract: Provided herein are methods, processes and apparatuses for non-invasive assessment of genetic variations.
    Type: Grant
    Filed: January 30, 2013
    Date of Patent: July 11, 2023
    Assignee: SEQUENOM, INC.
    Inventors: Cosmin Deciu, Mathias Ehrich, Dirk J. van den Boom, Zeljko Dzakula
  • Allele-specific sequence variation analysis
    Patent number: 9394565
    Abstract: Fragmentation-based methods and systems, particularly mass spectrometry based methods and systems, for the analysis of sequence variations including haplotypes are provided. Also provided are methods for obtaining a specific allele from a nucleic acid mixture, such as genomic DNA.
    Type: Grant
    Filed: September 2, 2004
    Date of Patent: July 19, 2016
    Assignee: AGENA BIOSCIENCE, INC.
    Inventors: Martin Beaulieu, Dirk J. Van Den Boom
  • PRODUCTS AND PROCESSES FOR MULTIPLEX NUCLEIC ACID IDENTIFICATION
    Publication number: 20130017960
    Abstract: Provided herein are products and processes for detecting the presence or absence of multiple target nucleic acids. Certain methods include amplifying the target nucleic acids, or portion thereof; extending oligonucleotides that specifically hybridize to the amplicons, where the extended oligonucleotides include a capture agent; capturing the extended oligonucleotides to a solid phase via the capture agent; releasing the extended oligonucleotide by competition with a competitor; detecting the extended oligonucleotide, and thereby determining the presence or absence of each target nucleic acid by the presence or absence of the extended oligonucleotide.
    Type: Application
    Filed: July 17, 2012
    Publication date: January 17, 2013
    Applicant: SEQUENOM, INC.
    Inventors: Christiane Honisch, Dirk J. Van Den Boom, Michael Mosko, Anders Nygren
  • METHODS AND COMPOSITIONS FOR DISEASE PROGNOSIS BASED ON NUCLEIC ACID METHYLATION
    Publication number: 20090317801
    Abstract: A large scale DNA methylation study was performed in patients with acute myeloid leukemia (AML) that revealed quantitative methylation patterns correlated with patient survival. Based on these results, a prognostic model was built which categorizes a patient's risk—either in a good or poor prognosis group. The findings provided herein support the use of genomic methylation markers for improved molecular classification and disease management in adult AML. Also, the results provide insight into the pathophysiology of AML and offer novel AML gene targets. Thus provided are methods and compositions for the prognosis of a subject suffering from acute myeloid leukemia (AML) based on the methylation state of nucleic acids. The methods may used alone to determine a patient's prognosis or in combination with other prognostic factors or markers such as gene expression.
    Type: Application
    Filed: August 2, 2006
    Publication date: December 24, 2009
    Applicant: Sequenom, Inc.
    Inventors: Dirk J. Van Den Boom, Mathias Ehrich