Abstract: The present invention relates to an immunoreactive molecule that specifically recognises and binds to human Ankyrin Repeat Domain-Containing Protein 30A (NY-BR-1) and, in particular, to an immunoreactive molecule, which shows no cross-reactivity to other human Ankyrin repeat domain containing proteins. The invention further relates to the use of such immunoreactive molecules in the treatment of cancer as well as in companion diagnostics methods.

Abstract: The present invention relates to an immunoreactive molecule that specifically recognises and binds to human Ankyrin Repeat Domain-Containing Protein 30A (NY-BR-1) and, in particular, to an immunoreactive molecule, which shows no cross-reactivity to other human Ankyrin repeat domain containing proteins. The invention further relates to the use of such immunoreactive molecules in the treatment of cancer as well as in companion diagnostics methods.

Abstract: A system assists during execution of a sequence of cuttings in a tree, wherein, during a cutting sequence, a first cut in the tree is followed by a second cut in the tree At least a part of an ideal course of the second cut depends on at least a part of a course of the first cut. An identification device identifies at least the part of the course of the first cut in the tree. A precalculation device precalculates at least the part of the ideal course of the second cut in the tree based on the identified part of the course of the first cut. An output device outputs cutting information for executing the second cut based on the precalculated part of the ideal course of the second cut.

Abstract: A system assists during felling of a tree. A provision device provides a property of the tree and/or a property of an environment of the tree, identifies at least part of a course of a cut in the tree for felling the tree and/or identifies a position and/or an orientation of a cutting apparatus executing the cut. A determination device obtains felling information related to an ideal felling direction of the tree, compares the identified part of the course to an obtained part of an ideal course of a cut to be executed in the tree for felling the tree in the ideal felling direction, compares the identified position and/or the identified orientation of the cutting apparatus to an obtained ideal position and/or an obtained ideal orientation of the cutting apparatus, and obtains cutting information based on the comparison. An output device outputs the obtained felling information and cutting information.

Abstract: The present invention relates to artificial Antigen Presenting Cells (aAPCs) comprising artificial Antigen Presenting Molecules (aAPMs) and, in particular, comprising dimers of the aAPMs as well as to methods for producing aAPCs. The invention further relates to compositions comprising the aAPCs and to vectors encoding the aAPMs of the aAPCs. Embodiments of the invention have been particularly developed for use in assays for determining an antigen-specific T cell response or a plurality of antigen-specific T cell responses and will be described hereinafter with reference to this application. However, it will be appreciated that the invention is not limited to this particular field of use.

Abstract: A system assists during execution of a sequence of cuttings in a tree, wherein, during a cutting sequence, a first cut in the tree is followed by a second cut in the tree At least a part of an ideal course of the second cut depends on at least a part of a course of the first cut. An identification device identifies at least the part of the course of the first cut in the tree. A precalculation device precalculates at least the part of the ideal course of the second cut in the tree based on the identified part of the course of the first cut. An output device outputs cutting information for executing the second cut based on the precalculated part of the ideal course of the second cut.

Abstract: A system assists during felling of a tree. A provision device provides a property of the tree and/or a property of an environment of the tree, identifies at least part of a course of a cut in the tree for felling the tree and/or identifies a position and/or an orientation of a cutting apparatus executing the cut. A determination device obtains felling information related to an ideal felling direction of the tree, compares the identified part of the course to an obtained part of an ideal course of a cut to be executed in the tree for felling the tree in the ideal felling direction, compares the identified position and/or the identified orientation of the cutting apparatus to an obtained ideal position and/or an obtained ideal orientation of the cutting apparatus, and obtains cutting information based on the comparison. An output device outputs the obtained felling information and cutting information.

Abstract: A method assists during felling of a tree. The method includes the steps of: providing a property of the tree and/or a property of an environment of the tree; obtaining felling information related to an ideal felling direction of the tree based on the provided property; and outputting the obtained felling information.

Abstract: A method assists during execution of a sequence of cuttings in a tree, wherein, during a cutting sequence, a first cut in the tree is followed by a second cut in the tree At least a part of an ideal course of the second cut depends on at least a part of a course of the first cut. The method includes the steps of: identifying at least the part of the course of the first cut in the tree; precalculating at least the part of the ideal course of the second cut in the tree based on the identified part of the course of the first cut; and outputting cutting information for executing the second cut based on the precalculated part of the ideal course of the second cut.

Abstract: A method assists during felling of a tree. The method includes the steps of: providing a property of the tree and/or a property of an environment of the tree; obtaining felling information related to an ideal felling direction of the tree based on the provided property; and outputting the obtained felling information.

Abstract: A method obtains an orientation of at least one section of a felled tree. The method includes the steps of: treating the at least one section of the felled tree; identifying an alignment and/or a position during the treatment; obtaining orientation information related to the orientation of the at least one section of the felled tree based on the identified alignment and/or the identified position; and outputting the obtained orientation information.

Abstract: A method assists during execution of a sequence of cuttings in a tree, wherein, during a cutting sequence, a first cut in the tree is followed by a second cut in the tree At least a part of an ideal course of the second cut depends on at least a part of a course of the first cut. The method includes the steps of: identifying at least the part of the course of the first cut in the tree; precalculating at least the part of the ideal course of the second cut in the tree based on the identified part of the course of the first cut; and outputting cutting information for executing the second cut based on the precalculated part of the ideal course of the second cut.

Abstract: The present invention relates to the field of treatment efficacy prediction in patients with malignant diseases. More precisely, this invention relates to the prediction of the efficacy of a treatment in cancer patients, based on the precise quantification of several biological markers that are related to the innate and adaptive immune response of said patient against said cancer.

Abstract: The invention relates to a broadband sound absorber (1) which comprises a sound-absorbing filler material between two microperforated film webs (2) which are contiguous on their edges, said filler material optionally containing heavy fillers. The broadband sound absorber (1) achieves excellent acoustic insulation and has microperforations (4) all over or only in sections, said filler material optionally containing heavy fillers (mass density) and one or both microperforated film webs (2) having the same thickness across their surface or thickened portions (3, 5) of the same or a different material in some sections.

Abstract: The invention relates to a broadband sound absorber (1) which comprises a sound-absorbing filler material between two microperforated film webs (2) which are contiguous on their edges, said filler material optionally containing heavy fillers. The broadband sound absorber (1) achieving excellent acoustic insulation comprises a sound-absorbing filler material between two film webs (2) which are contiguous on their edges and have microperforations (4) all over or only in sections, said filler material optionally containing heavy fillers (mass density) and one or both microperforated film webs (2) having the same thickness across their surface or thickened portions (3, 5) of the same or a different material in some sections.

Abstract: Provided are novel tumor-specific binding molecules, particularly human antibodies as well as fragments, derivatives and variants thereof that recognize tumor-associated antigens and that are obtained from a tumor patient who shows at least partial clinical response or is symptom-free. In addition, pharmaceutical compositions comprising such binding molecules, antibodies and mimics thereof and methods of screening for novel binding molecules, which may or may not be antibodies as well as targets in the treatment of tumors are described.

Abstract: Provided are novel human tumor-specific antibodies as well as fragments, derivatives and variants thereof that recognize tumor-associated antigen NY-ESO-1. In addition, pharmaceutical compositions comprising such antibodies and mimics thereof in the treatment of tumors are described.