Patents by Inventor Dirk M. Spitzer

Dirk M. Spitzer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mesothelin-targeted trail trimer
    Patent number: 11952410
    Abstract: The present disclosure provides constructs that comprise (a) a TNF-related apoptosis-inducing ligand (TRAIL) trimer comprising three consecutive extracellular TRAIL domains fused together in a head-to-tail configuration; (b) an epitope binding agent, and (c) optionally one or more additional components, wherein the epitope binding agent competitively inhibits binding of P4-TR3 or HN1-TR3 to cell surface human mesothelin. Constructs of the present disclosure induce apoptosis in cells expressing human mesothelin and a death receptor (DR4 or DR5) on the cell's surface.
    Type: Grant
    Filed: May 2, 2018
    Date of Patent: April 9, 2024
    Assignee: Washington University
    Inventors: Dirk M. Spitzer, William G. Hawkins
  • MESOTHELIN-TARGETED TRAIL TRIMER
    Publication number: 20210188945
    Abstract: The present disclosure provides constructs that comprise (a) a TNF-related apoptosis-inducing ligand (TRAIL) trimer comprising three consecutive extracellular TRAIL domains fused together in a head-to-tail configuration; (b) an epitope binding agent, and (c) optionally one or more additional components, wherein the epitope binding agent competitively inhibits binding of P4-TR3 or HN1-TR3 to cell surface human mesothelin. Constructs of the present disclosure induce apoptosis in cells expressing human mesothelin and a death receptor (DR4 or DR5) on the cell's surface.
    Type: Application
    Filed: May 2, 2018
    Publication date: June 24, 2021
    Inventors: Dirk M. Spitzer, William G. Hawkins