Abstract: A method includes the steps of: providing a mold substrate and a cover substrate that are bonded to each other, wherein a surface region of the mold substrate and/or of the cover substrate is structured so as to form an enclosed cavity between the cover substrate and the mold substrate; tempering the cover substrate and the mold substrate so as to decrease the viscosity of the glass material of the cover substrate, and providing an overpressure in the enclosed cavity compared to the surrounding atmosphere so as to cause, on the basis of the decreased viscosity of the glass material of the cover substrate and the overpressure in the enclosed cavity compared to the surrounding atmosphere, bulging of the glass material of the cover substrate starting from the enclosed cavity up to a stop area, spaced apart from the cover substrate, of a stop element so as to acquire a molded cover substrate with a cap element; and removing the stop element and the mold substrate from the molded cover substrate.

Abstract: The invention relates to new proline derivatives of formula (I) as cGAS inhibitors, wherein wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and G are defined as in claim 1, and prodrugs or pharmaceutically acceptable salts of these compounds for the treatment of diseases such as systemic lupus erythematosus, systemic sclerosis (SSc), non-alcoholic steatotic hepatitis (NASH), interstitial lung disease (ILD) and idiopathic pulmonary fibrosis (IPF).

Abstract: The invention relates to new proline derivatives of formula (I) as cGAS inhibitors, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and G are defined as in claim 1, and prodrugs or pharmaceutically acceptable salts of these compounds for the treatment of diseases such as systemic lupus erythematosus, systemic sclerosis (SSc), non-alcoholic steatotic hepatitis (NASH), interstitial lung disease (ILD) and idiopathic pulmonary fibrosis (IPF).

Abstract: The present invention refers to a non-collapsible and non-foldable container for lyophilization of a product, said container comprising: a) a plastic tray comprising a bottom wall, a continuous peripheral side wall defining an opening, and a continuous circumferential rim which is outwardly bulged; b) a top wall for completely covering said opening, which top wall is comprising a membrane which membrane is vapour-permeable and provides a bacterial barrier; c) a removable impermeable snap-on lid for completely covering said top wall and said membrane. The container of the present invention is used for lyophilization of products and is easy to handle and provides a suitable shape for heat transfer during the lyophilization process. Further, the inventive container provides means for easy handling of opening and closing the membrane area before starting the lyophilization process, and also provides means for easy and reliable sealing after the lyophilization process, thereby protecting the membrane.