Abstract: The present invention relates to Map4K1 inhibitors of formula (I) (I), wherein A, E, G, Q, R1, R2 and R4 have the same meaning as defined in the description, to pharmaceutical compositions and combinations comprising the compounds according to the invention, and to the prophylactic and therapeutic use of the inventive compounds, respectively to the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for neoplastic disorders, respectively cancer or conditions with dysregulated immune responses or other disorders associated with aberrant MAP4K1 signaling, as a sole agent or in combination with other active ingredients.

Abstract: A vehicle steering wheel system is provided. The system includes a steering wheel body with a hub region for attachment to a steering shaft of a vehicle steering system, a steering wheel rim and at least one spoke for attaching the steering wheel rim to the hub region; an electromechanical triggering device for triggering an acoustic output by means of an acoustic warning device of the vehicle, wherein the triggering device has an impact absorber cover and at least one force transducer wherein a force value threshold is predefined for each force transducer, and a wake-up signal is transmitted via the data connection to the evaluation unit if the force value threshold is exceeded by at least one force value, so that the latter changes from the energy-saving mode into the operating mode in which an actuating force value is determined by force value measured by the at least one force transducer.

Abstract: The present disclosure is concerned with the technical field of marking objects with optically readable codes and reading out (decoding) the codes. Subjects of the present disclosure are a method, a system and a computer program product for decoding optically readable codes introduced in surfaces of objects.

Abstract: A mechanism for generating and providing one or more quality measures of a mapping function (for mapping electrical responses of an electrode to a predicted position of that electrode within an anatomical cavity) to a user, such as a clinician. Each quality measure predicts or indicates a quality of a mapping function with respect to a particular part of an anatomical cavity, for instance, indicating a predicted accuracy of the mapping function for predicting a position of an electrode located within a particular portion of the anatomical cavity. A user-perceptible output is provided that indicates the quality measure for the user.

Abstract: The present disclosure is concerned with the technical field of marking objects with optically readable codes and reading out (decoding) the codes. Subjects of the present disclosure are a method, a system and a computer program product for decoding optically readable codes introduced in surfaces of objects.

Abstract: An imaging system (MIS), optionally a medical imaging system, with wireless communication capability and related method. The imaging system comprises a gantry (RG) rotatable around a rotation axis. The gantry includes a detector device (D) capable of recording, in plural spatial positions, measurement data in relation to a subject (such as a patient) (PAT) to be imaged. The system also includes a radio transmitter (TX) for generating a directed radio beam propagatable along a propagation axis to transmit the measurement data to a radio receiver (RX). The radio transmitter (TX) is arranged at the rotatable gantry and is operable so that the propagation direction intersects the rotation axis in a location that is situated away from the rotatable gantry.

Abstract: Mechanical image acquisition systems (such as medical C-arms) frequently accumulate geometrical errors which must be calibrated out using a calibration phantom. A more frequent regime of system calibration implies a less frequent use of the C-arm for clinical applications. The present application proposes to identify common biases between the acquired projection frame sequences from the same mechanical image acquisition system in first and second acquisitions, and to compare this to expected calibration data of the mechanical image acquisition system to generate frame deviation measures. If a resemblance between the first and second sequences of frame deviation measures is obtained, one or more calibration actions are performed (such as alerting the user that calibration should be provided, and/or automatically correcting for the geometry deviation).

Abstract: The invention relates to a hinge lock consisting of a first hinge part (1) for fastening to the outside of a door and a second hinge part (2) for fastening on the outside of a door frame, wherein the first hinge part (1) has an actuating device, by means of which the first (1) and the second hinge part (2) can be unlocked and locked with one another. The actuating device interacts with a shaft (16), which is suitable for passing through the door. An inner handle (23) is arranged at the end of the shaft (16) facing away from the actuating device, by means of which the first (1) and the second hinge part (2) can be unlocked and locked with one another. The shaft (16) is surrounded by at least one pipe part (18, 18?).

Abstract: The invention relates to off-center detector X-ray tomography reconstruction of an image of an object on the basis of projection data acquired during a rotation of an X-ray source and the off-center detector around the object in two rotational passes of less than 360°, wherein a focus point of the X-ray beam travels along largely overlapping arcs (401, 402) in the two rotational passes, the off-center detector being positioned asymmetrically with respect to a central of the X-ray beam and a direction of a detector offset being reversed between the passes. According to the invention, redundancy weighting of the projection data with respect to a redundant acquisition of projection values during each of the rotational passes is made using a redundancy weighting function determined on the basis of a union of the arcs (401, 402).

Abstract: The invention relates to off-center detector 3D X-ray or proton radiography reconstruction. Redundancy weighting with a steep weighting function around the iso-axis typically leads to artifacts in the reconstruction, for example, if inconsistencies between two nominal redundant projections occur, e.g. due to slightly incorrect detector calibration or scatter correction, etc. With the present invention, an approach is presented for overcoming or mitigating these problems.

Abstract: A device for agricultural management includes a processing unit to determine at least one geographical location of an agricultural land area, the determination comprising utilization of a GPS unit. Agricultural data is provided from an input unit to the processing unit. The processing unit determines agricultural management data, the determination comprising utilization of the at least one geographical location and the agricultural data. An output unit outputs agricultural management information to a user of the device on the basis of the agricultural management data.

Abstract: Mechanical image acquisition systems (such as medical C-arms) frequently accumulate geometrical errors which must be calibrated out using a calibration phantom. A more frequent regime of system calibration implies a less frequent use of the C-arm for clinical applications. The present application proposes to identify common biases between the acquired projection frame sequences from the same mechanical image acquisition system in first and second acquisitions, and to compare this to expected calibration data of the mechanical image acquisition system to generate frame deviation measures. If a resemblance between the first and second sequences of frame deviation measures is obtained, one or more calibration actions are performed (such as alerting the user that calibration should be provided, and/or automatically correcting for the geometry deviation).

Abstract: The present invention relates to a guidance device (10) for a TEE probe (20), a medical imaging system (1), a method for guiding a TEE probe (20), a computer program element for controlling such device and a computer readable medium having stored such computer program element. The guidance device (10) for a TEE probe (20) comprises an image data provision unit (11), and a processing unit (12). The image data provision unit (11) is configured to provide first image data showing an interventional device (40) and a TEE probe (20) in an initial position and orientation. The processing unit (12) is configured to determine a centerline of the interventional device (40) in the first image data. The processing unit (12) is configured to determine a plane (41) orthogonal to a tangent of the centerline as viewing plane. The processing unit (12) is configured to calculate an imaging plane and an imaging orientation of the TEE probe (20) to lie approximately in the viewing plane.

Abstract: A hand held device for land management is described for a user of the device to provide agricultural information relating to a field, wherein the agricultural information includes information on at least one crop. A transmitter of the device transmits information including the agricultural information relating to the field. A receiver of the device receives agricultural data that includes best practices for the growing of the at least one crop. A processing unit of the device determines agricultural management information on the basis of the agricultural data. An output unit of the device outputs the agricultural management information to the user of the device.

Abstract: A hand held device for economic agricultural management is described for a user of the device to provide agricultural information relating to a field, wherein the agricultural information includes information on at least one crop. A transmitter of the device transmits information including the agricultural information relating to the field. A receiver of the device receives agricultural data that includes economic information relating to the at least one crop. A processing unit of the device determines economic agricultural management information on the basis of the agricultural data. An output unit of the device outputs the economic agricultural management information to the user of the device.

Abstract: The present invention relates to providing a projection data for providing a guidance image. In order to provide an enhanced guiding image technique for generating a guidance image of the patient's anatomy to be projected on the body surface of the patient, such that a at least a basis for a corrected guidance image for a better correlation to the patient's current motion can be provided, in particular to the patient's current breathing motion state, a device (10) for providing a projection data set is provided that comprises a storage means (12), an input interface (14), a processing unit (16) and an output interface (18). The storage means is configured to store a pre-determined basis data set representing a 3D tomographic image of a subject (20). The input interface is configured to receive reference data representing a current spatial depiction at least of a target region (22) of the subject. The processing unit is configured to register the reference data on the pre-determined basis data set.

Abstract: A method includes receiving radiation with a hybrid data detection system of an imaging system. The hybrid data detection system includes a hybrid data detector array with a set of spectral detectors and a set of integrating detectors that are arranged along a transverse axis of an examination region. The method further includes generating a set of truncated spectral projections with the first set of spectral detectors. The method further includes estimating a set of spectral projections for the integrating detectors. The method further includes combining the set of truncated spectral projections and the estimated set of spectral projections. The method further includes estimating a set of spectral projections based on the combined set to produce a complete set of spectral projections. The method further includes processing the complete set of spectral projections to generate volumetric image data.

Abstract: The invention relates to off-center detector X-ray tomography reconstruction of an image of an object on the basis of projection data acquired during a rotation of an X-ray source and the off-center detector around the object in two rotational passes of less than 360°, wherein a focus point of the X-ray beam travels along largely overlapping arcs (401, 402) in the two rotational passes, the off-center detector being positioned asymmetrically with respect to a central of the X-ray beam and a direction of a detector offset being reversed between the passes. According to the invention, redundancy weighting of the projection data with respect to a redundant acquisition of projection values during each of the rotational passes is made using a redundancy weighting function determined on the basis of a union of the arcs (401, 402).

Abstract: The invention relates to off-center detector 3D X-ray or proton radiography reconstruction. Redundancy weighting with a steep weighting function around the iso-axis typically leads to artifacts in the reconstruction, for example, if inconsistencies between two nominal redundant projections occur, e.g. due to slightly incorrect detector calibration or scatter correction, etc. With the present invention, an approach is presented for overcoming or mitigating these problems.

Abstract: The invention relates to an imaging system (10) for imaging an elongated region of interest of an object, an imaging method for imaging an elongated region of interest of an object, a computer program element for controlling such system for performing such method and a computer readable medium having stored such computer program element. The imaging system (10) comprises an acquisition unit (11) and a processing unit (13). The acquisition unit (11) is a C-arm acquisition unit and configured to acquire first image data of the object to be imaged with a first imaging parameter. The acquisition unit (11) is further configured to acquire second, different image data of an object to be imaged with a second imaging parameter. The second geometric imaging parameter is defined based on object specific data for the volume data to be aligned with the elongated region of interest of the object to be imaged. The processing unit (13) is configured to combine the first and second image data into volume data.