Patents by Inventor Dirk Schwarzer

Dirk Schwarzer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Non-Ribosomal Peptide Synthetases
    Publication number: 20100297751
    Abstract: Novel tailor-made artificial non-ribosomal peptide synthetases (NRPSs) for non-ribosomal synthesis and/or modification of peptides of a predetermined length and composition and/or for modification of individual amino acids are described. The fusion of building units of said peptide synthetases in particular linker regions makes it possible to specifically prepare by means of “modular molecule construction kits” NRPSs which are capable of synthesizing peptides of a desired structure.
    Type: Application
    Filed: June 21, 2010
    Publication date: November 25, 2010
    Inventors: Mohamed A. Marahiel, Henning Mootz, Dirk Schwarzer, Sascha Dökel, Uwe Linne
  • Non-Ribosomal Peptide Synthetases
    Publication number: 20100285563
    Abstract: Novel tailor-made artificial non-ribosomal peptide synthetases (NRPSs) for non-ribosomal synthesis and/or modification of peptides of a predetermined length and composition and/or for modification of individual amino acids are described. The fusion of building units of said peptide synthetases in particular linker regions makes it possible to specifically prepare by means of “modular molecule construction kits” NRPSs which are capable of synthesizing peptides of a desired structure.
    Type: Application
    Filed: June 21, 2010
    Publication date: November 11, 2010
    Inventors: Mohamed A. Marahiel, Henning Mootz, Dirk Schwarzer, Sascha Dokel, Uwe Linne
  • Methods for preparation of macrocyclic molecules and macrocyclic molecules prepared thereby
    Patent number: 7279304
    Abstract: The preparation of macrocyclic molecules from linear, synthetic thioester precursors is disclosed. An excised thioesterase domain isolated from either a polyketide synthases (PKS) or non-ribosomal peptide synthetases (NRPS) multido system catalyzes the cyclization reaction. Thioester substrates also are described that are efficiently cyclized by the method of the present invention. Additionally, macrocyclic molecules, including macrolactones and macrolactams, that are prepared by the macrocyclization methods of the invention are described.
    Type: Grant
    Filed: December 15, 2001
    Date of Patent: October 9, 2007
    Assignee: President and Fellows of Harvard College
    Inventors: Christopher Thomas Walsh, John W. Trauger, Rahul Manu Kohli, Michael D. Burkart, Mohammed A. Maraheil, Henning Dieter Mootz, Dirk Schwarzer
  • Methods for preparation of macrocyclic molecules and macrocyclic molecules prepared thereby
    Publication number: 20020192773
    Abstract: The preparation of macrocyclic molecules from linear, synthetic thioester precursors is disclosed. An excised thioesterase domain isolated from either a PKS or NRPS multidomain system catalyzes the cyclization reaction. Thioester substrates also are described that are efficiently cyclized by the method of the present invention. Additionally, macrocyclic molecules, including macrolactones and macrolactams, that are prepared by the macrocyclization methods of the invention are described.
    Type: Application
    Filed: December 15, 2001
    Publication date: December 19, 2002
    Applicant: The President and Fellows of Harvard College
    Inventors: Christopher Thomas Walsh, John W. Trauger, Rahul Manu Kohli, Michael D. Burkart, Mohammed A. Maraheil, Henning Dieter Mootz, Dirk Schwarzer