Patents by Inventor Dirk Spielvogel

Dirk Spielvogel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing prophyrin derivatives, such as protoprophyrin (IX) and synthesis intermediates
    Patent number: 8420805
    Abstract: The present invention relates to a process for preparing a porphyrin of formula (I), optionally in the form of a salt with an alkali metal and/or in the form of a metal complex: in which: R and R? are as defined in claim 1, comprising: a step of condensation, in an acidic medium, between a dipyrromethane of formula (II): in which R?b is as defined above for (I), and a dipyrromethane of formula (III): in which R? is as defined in claim 1, and also the compounds of formula (III).
    Type: Grant
    Filed: August 25, 2011
    Date of Patent: April 16, 2013
    Assignee: Sanofi Pasteur S.A.
    Inventors: Pierre Martin, Markus Mueller, Dirk Spielvogel, Dietmar Flubacher, Andreas Boudier
  • Process For Preparing Prophyrin Derivatives, Such As Protoprophyrin (IX) And Synthesis Intermediates
    Publication number: 20110306761
    Abstract: The present invention relates to a process for preparing a porphyrin of formula (I), optionally in the form of a salt with an alkali metal and/or in the form of a metal complex: in which: R and R? are as defined in claim 1, comprising: a step of condensation, in an acidic medium, between a dipyrromethane of formula (II): in which R?b is as defined above for (I), and a dipyrromethane of formula (III): in which R? is as defined in claim 1, and also the compounds of formula (III).
    Type: Application
    Filed: August 25, 2011
    Publication date: December 15, 2011
    Applicant: SANOFI PASTEUR SA
    Inventors: Pierre Martin, Markus Mueller, Dirk Spielvogel, Dietmar Flubacher, Andreas Boudier
  • Process for preparing porphyrin derivatives, such as protoporphyrin (IX) and synthesis intermediates
    Patent number: 8026358
    Abstract: The present invention relates to a process for preparing a porphyrin of formula (I), optionally in the form of a salt with an alkali metal and/or in the form of a metal complex: in which: R and R? are as defined in claim 1, comprising: a step of condensation, in an acidic medium, between a dipyrromethane of formula (II): in which R?b is as defined above for (I), and a dipyrromethane of formula (III): in which R? is as defined in claim 1, and also the compounds of formula (III).
    Type: Grant
    Filed: March 28, 2008
    Date of Patent: September 27, 2011
    Assignee: Sanofi Pasteur S.A.
    Inventors: Pierre Martin, Markus Mueller, Dirk Spielvogel, Dietmar Flubacher, Andreas Boudier
  • Process for preparing tetrahydrobiopterin and analogs of tetrahydrobiopterin
    Patent number: 7732599
    Abstract: Process for the preparation of tetrahydrobiopterin from neopterin and/or 6-substituted pterins with an improved yield and a high stereoselectivity. Also disclosed herein are novel individual intermediates prepared in the preparation of tetrahydrobiopterin, such as selectively protected neopterin useful for the preparation of tetrahydrobiopterin.
    Type: Grant
    Filed: November 17, 2004
    Date of Patent: June 8, 2010
    Assignees: BioMarin Pharmaceutical Inc., Merck Eprova AG
    Inventors: Rudolf Moser, Viola Groehn, Andreas Schumacher, Pierre Martin, Dirk Spielvogel
  • Process For Preparing Porphyrin Derivatives, Such As Protoporphyrin (IX) And Synthesis Intermediates
    Publication number: 20080242857
    Abstract: The present invention relates to a process for preparing a porphyrin of formula (I), optionally in the form of a salt with an alkali metal and/or in the form of a metal complex: in which: R and R? are as defined in claim 1, comprising: a step of condensation, in an acidic medium, between a dipyrromethane of formula (II): in which R?b is as defined above for (I), and a dipyrromethane of formula (III): in which R? is as defined in claim 1, and also the compounds of formula (III).
    Type: Application
    Filed: March 28, 2008
    Publication date: October 2, 2008
    Applicant: SANOFI PASTEUR SA
    Inventors: Pierre Martin, Markus Mueller, Dirk Spielvogel, Dietmar Flubacher, Andreas Boudier
  • Process for Preparing Tetrahydrobiopterin and Analogs of Tetrahydrobiopterin
    Publication number: 20070244322
    Abstract: Process for the preparation of tetrahydrobiopterin from neopterin and/or 6-substituted pterins with an improved yield and a high stereoselectivity. Also disclosed herein are novel individual intermediates prepared in the preparation of tetrahydrobiopterin, such as selectively protected neopterin useful for the preparation of tetrahydrobiopterin.
    Type: Application
    Filed: November 17, 2004
    Publication date: October 18, 2007
    Applicant: Merck Eprova AG
    Inventors: Rudolf Moser, Viola Groehn, Andreas Schumacher, Pierre Martin, Dirk Spielvogel
  • Difluoronucleosides and process for preparation thereof
    Publication number: 20060173174
    Abstract: A stereoselective process for the preparation of a 2?,2?-difluronucleoside is provided. In the process, a protected 2?2?-difluorofuranose is coupled with a base selected from the group consisting of pyrimidine and purine derivatives in the presence of a Lewis acid, wherein the protected 2?2?-difluorofuranose has a 1-position leaving group and 3- and 5-position protecting groups, and, when the base comprises 1 or more oxygen atoms, the base is a protected base, wherein each oxygen atom is protected with a protecting group.
    Type: Application
    Filed: December 8, 2005
    Publication date: August 3, 2006
    Inventors: Anne-Ruth Born, Pierre Martin, Dirk Spielvogel, Marco Villa