Abstract: A compound comprising a C-type lectin Carbohydrate Recognition Domain (CRD) and an immunoglobulin Fc domain for use in treating or preventing a pathogen infection in a non-human, non-murine subject. Preferably the non-human, non-murine subject is not considered to be an immunocompromised or immunosuppressed subject. The non-human, non-murine subject may be a ruminant; a livestock; companion or racing animal. The CRD, immunoglobulin Fc domain and the non-human, non-murine subject may be bovine. The pathogen infection typically comprises infection by a bacterium, optionally Staphylococcus aureus or Streptococcus Uberis or Streptococcus Agalactiae/dysgalactiae. The subject (for example bovine subject) may have mastitis, subclinical mastitis, acute mastitis, chronic mastitis, high somatic cell count (high SSC), metritis or endometritis. The non-human, non-murine subject may typically be further administered an antibiotic or antifungal agent.

Abstract: A compound for vaccination of an animal comprising (i) a moiety which selectively binds to a dendritic cell in the animal but which does not naturally occur in the animal and (ii) an antigen. Typically, the moiety which selectively binds as said binds to DC-SIGN. The moiety may be HIV-1 gp 120. The compound of the invention may be used to vaccinate animals and, following vaccination, they may be distinguished from naturally infected animals.