Patents by Inventor Dirk Wienke

Dirk Wienke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Piperazine derivatives as FASN inhibitors
    Patent number: 9809552
    Abstract: Compounds of the formula I in which R, X1, X2, X3, X4, R1, R2 and q have the meanings indicated in Claim 1, are inhibitors of fatty acid synthase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Grant
    Filed: February 24, 2014
    Date of Patent: November 7, 2017
    Assignee: MERCK PATENT GMBH
    Inventors: Wolfgang Staehle, Christos Tsaklakidis, Manja Friese-Hamim, Birgitta Leuthner, Dirk Wienke
  • Benzyl piperidine compounds as lysophosphatidic acid (LPA) receptor antagonist
    Patent number: 9527850
    Abstract: The invention provides novel substituted benzyl piperidine compounds according to Formula (I) as lysophosphatidic acid (LPA) receptor antagonists, their manufacture and use for the treatment of proliferative or inflammatory diseases, such as cancer, fibrosis or arthritis.
    Type: Grant
    Filed: September 7, 2012
    Date of Patent: December 27, 2016
    Assignee: Merck Patent GmbH
    Inventors: Kai Schiemann, Wolfgang Staehle, Michael Busch, Dirk Wienke, Oliver Poeschke, Christa Burger
  • PIPERAZINE DERIVATIVES AS FASN INHIBITORS
    Publication number: 20160280655
    Abstract: Compounds of the formula I in which R, X1, X2, X3, X4, R1, R2 and q have the meanings indicated in Claim 1, are inhibitors of fatty acid synthase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Application
    Filed: February 24, 2014
    Publication date: September 29, 2016
    Applicant: MERCK PATENT GMBH
    Inventors: Wolfgang STAEHLE, Christos TSAKLAKIDIS, Manja FRIESE-HAMIM, Birgitta LEUTHNER, Dirk WIENKE
  • Hydropyrrolopyrrole derivatives for use as fatty acid synthase inhibitors
    Patent number: 9416133
    Abstract: Compounds of the formula I in which R1, R2, R, X1, X2, X3, X4, n1, n2, n3 and n4 have the meanings indicated in claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Grant
    Filed: August 30, 2013
    Date of Patent: August 16, 2016
    Assignee: MERCK PATENT GMBH
    Inventors: Wolfgang Staehle, Christos Tsaklakidis, Birgitta Leuthner, Dirk Wienke, Frank Czauderna, Ansgar Wegener
  • HYDROPYRROLOPYRROLE DERIVATIVES FOR USE AS FATTY ACID SYNTHASE INHIBITORS
    Publication number: 20150252046
    Abstract: Compounds of the formula I in which R1, R2, R, X1, X2, X3, X4, n1, n2, n3 and n4 have the meanings indicated in Claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Application
    Filed: August 30, 2013
    Publication date: September 10, 2015
    Applicant: MERCK PATENT GMBH
    Inventors: Wolfgang Staehle, Christos Tsaklakidis, Birgitta Leuthner, Dirk Wienke, Frank Czauderna, Ansgar Wegener
  • Pyrazolopyridinone derivatives as LPA receptor antagonists
    Patent number: 9067938
    Abstract: The present invention relates to novel pyrazolopyridinone derivatives according to formula (I) and a process of manufacturing thereof. These pyrazolopyridinone derivatives can be used as LPA receptor antagonists for the treatment of various herein disclosed diseases.
    Type: Grant
    Filed: August 6, 2014
    Date of Patent: June 30, 2015
    Assignee: Merck Patent GmbH
    Inventors: Kai Schiemann, Wolfgang Staehle, Sr., Dirk Wienke
  • Inhibitors of sphingosine kinase
    Patent number: 9062015
    Abstract: The present invention relates to compounds of the formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, M1, M2, M3, M4, Y1, Y2, V, W, n, m and o have the meanings given in Claim 1, and physiologically acceptable salts, derivatives, prodrugs, solvates, tautomers and stereoisomers thereof, including mixtures thereof in all ratios, for use in the treatment of diseases which are influenced by inhibition of Sph kinase 1.
    Type: Grant
    Filed: November 22, 2010
    Date of Patent: June 23, 2015
    Assignee: Merck Patent GmbH
    Inventors: Frank Stieber, Dirk Wienke
  • Benzyl Piperidine Compounds as Lysophosphatidic Acid (LPA) Receptor Antagonist
    Publication number: 20150011557
    Abstract: The invention provides novel substituted benzyl piperidine compounds according to Formula (I) as lysophosphatidic acid (LPA) receptor antagonists, their manufacture and use for the treatment of proliferative or inflammatory diseases, such as cancer, fibrosis or arthritis.
    Type: Application
    Filed: September 7, 2012
    Publication date: January 8, 2015
    Applicant: Merck Patent GmbH
    Inventors: Kai Schiemann, Wolfgang Staehle, Michael Busch, Dirk Wienke, Oliver Poeschke, Christa Burger
  • Inhibitors of sphingosine kinase
    Patent number: 8907098
    Abstract: The present invention relates to compounds of the formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, M1, M2, M3, Y1, Y2, V, W, n, m and o have the meanings given herein, and physiologically acceptable salts, derivatives, prodrugs, solvates, tautomers and stereoisomers thereof, including mixtures thereof in all ratios, for use in the treatment of diseases which are influenced by inhibition of Sph kinase 1.
    Type: Grant
    Filed: November 18, 2010
    Date of Patent: December 9, 2014
    Assignee: MERCK PATENT GmbH
    Inventors: Frank Stieber, Dirk Wienke
  • PYRAZOLOPYRIDINONE DERIVATIVES AS LPA RECEPTOR ANTAGONISTS
    Publication number: 20140350046
    Abstract: The present invention relates to novel pyrazolopyridinone derivatives according to formula (I) and a process of manufacturing thereof. These pyrazolopyridinone derivatives can be used as LPA receptor antagonists for the treatment of various herein disclosed diseases.
    Type: Application
    Filed: August 6, 2014
    Publication date: November 27, 2014
    Applicant: Merck Patent GmbH
    Inventors: Kai SCHIEMANN, Wolfgang STAEHLE, SR., Dirk WIENKE
  • Pyrazolopyridinone derivatives as LPA receptor antagonists
    Patent number: 8859775
    Abstract: The present invention relates to novel pyrazolopyridinone derivatives according to formula (I) and a process of manufacturing thereof. These pyrazolopyridinone derivatives can be used as LPA receptor antagonists for the treatment of various herein disclosed diseases.
    Type: Grant
    Filed: August 5, 2011
    Date of Patent: October 14, 2014
    Assignee: Merck Patent GmbH
    Inventors: Kai Schiemann, Wolfgang Staehle, Dirk Wienke
  • 2, 5-diamino-substituted pyrido [4, 3-D] pyrimidines as autotaxin inhibitors against cancer
    Patent number: 8530650
    Abstract: The present invention relates to pyridopyrimidine derivatives according to formula (I) as autotaxin inhibitors and the use of such compounds for the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by increased lysophosphatic acid levels and/or the activation of autotaxin, in particular of different cancers.
    Type: Grant
    Filed: November 3, 2009
    Date of Patent: September 10, 2013
    Assignee: MERCK PATENT GmbH
    Inventors: Kai Schiemann, Melanie Schultz, Wolfgang Staehle, Ingo Kober, Dirk Wienke, Mireille Krier
  • PYRAZOLOPYRIDINONE DERIVATIVES AS LPA RECEPTOR ANTAGONISTS
    Publication number: 20130165478
    Abstract: The present invention relates to novel pyrazolopyridinone derivatives according to formula (I) and a process of manufacturing thereof. These pyrazolopyridinone derivatives can be used as LPA receptor antagonists for the treatment of various herein disclosed diseases.
    Type: Application
    Filed: August 5, 2011
    Publication date: June 27, 2013
    Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
    Inventors: Kai Schiemann, Wolfgang Staehle, Dirk Wienke
  • Thiazolyl piperidine derivatives
    Patent number: 8436186
    Abstract: Compounds of the formula (I), in which R1, R2, R3, R4, R5, R6, R9, R10, R11, Q and W have the meanings indicated in Claim 1, and precursors thereof are inhibitors of sphingosine kinase and can be employed, inter alia, for the treatment of tumors.
    Type: Grant
    Filed: May 28, 2009
    Date of Patent: May 7, 2013
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Frank Stieber, Timo Heinrich, Dirk Wienke
  • INHIBITORS OF SPHINGOSINE KINASE
    Publication number: 20120252789
    Abstract: The present invention relates to compounds of the formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, M1, M2, M3, M4, Y1, Y2, V, W, n, m and o have the meanings given in Claim 1, and physiologically acceptable salts, derivatives, prodrugs, solvates, tautomers and stereoisomers thereof, including mixtures thereof in all ratios, for use in the treatment of diseases which are influenced by inhibition of Sph kinase 1.
    Type: Application
    Filed: November 22, 2010
    Publication date: October 4, 2012
    Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
    Inventors: Frank Stieber, Dirk Wienke
  • INHIBITORS OF SPHINGOSINE KINASE
    Publication number: 20120252815
    Abstract: The present invention relates to compounds of the formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, M1, M2, M3, Y1, Y2, V, W, n, m and o have the gleanings given herein, and physiologically acceptable salts, derivatives, prodrugs, solvates, tautomers and stereoisomers thereof, including mixtures thereof in all ratios, for use in the treatment of diseases which are influenced by inhibition of Sph kinase 1.
    Type: Application
    Filed: November 18, 2010
    Publication date: October 4, 2012
    Applicant: Merck Patent Gesellschaft MIT Beschrankter Haftung
    Inventors: Frank Stieber, Dirk Wienke
  • 2, 5-DIAMINO-SUBSTITUTED PYRIDO [4, 3-D] PYRIMIDINES AS AUTOTAXIN INHIBITORS AGAINST CANCER
    Publication number: 20110237583
    Abstract: The present invention relates to pyridopyrimidine derivatives according to formula (I) as autotaxin inhibitors and the use of such compounds for the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by increased lysophosphatic acid levels and/or the activation of autotaxin, in particular of different cancers.
    Type: Application
    Filed: November 3, 2009
    Publication date: September 29, 2011
    Inventors: Kai Schiemann, Melanie Schultz, Wolfgang Staehle, Ingo Kober, Dirk Wienke, Mireille Krier
  • BENZONAPHTYRIDINE COMPOUNDS AS INHIBITORS OF AUTOTAXIN
    Publication number: 20110230471
    Abstract: Compounds of the formula (I), in which R1, R2, R3, R4, R5, D, Z, X, Y, m and p have the meanings indicated in Claim 1, can and be employed for the treatment of tumours.
    Type: Application
    Filed: November 5, 2009
    Publication date: September 22, 2011
    Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
    Inventors: Wolfgang Staehle, Ingo Kober, Kai Schiemann, Melanie Schultz, Dirk Wienke
  • THIAZOLYL PIPERIDINE DERIVATIVES
    Publication number: 20110105505
    Abstract: Compounds of the formula (I), in which R1, R2, R3, R4, R5, R6, R9, R10, R11, Q and W have the meanings indicated in Claim 1, and precursors thereof are inhibitors of sphingosine kinase and can be employed, inter alia, for the treatment of tumours.
    Type: Application
    Filed: May 28, 2009
    Publication date: May 5, 2011
    Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRÄNKTER HAFTUNG
    Inventors: Frank Stieber, Timo Heinrich, Dirk Wienke