Patents by Inventor Dirk Willem van Bekkum

Dirk Willem van Bekkum has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Interleukin-3 gene therapy for cancer
    Publication number: 20030082137
    Abstract: A method for treating of tumors, in particular malignant solid tumors, using adenovirus-derived material and IL-3, so that the adenovirus preferably encodes IL-3 activity, which is given systematically to a mammal, optionally in an isolated perfusion setting. Preferably, IL-3 activity is combined with other cytotoxic activity.
    Type: Application
    Filed: August 28, 2002
    Publication date: May 1, 2003
    Inventors: Marie Elisabeth Draijer-van der Kaaden, Abraham Bout, Dirk Willem van Bekkum
  • Interleukin-3 gene therapy for cancer
    Patent number: 6495131
    Abstract: Means and methods for treating tumors in a mammal, in particular, malignant solid tumors, using adenovirus derived material and interleukin-3 (“IL-3 ”). Tthe adenovirus derived material preferably encodes IL-3 activity. Such an adenovirus is preferably administered systemically to the mammal, optionally in an isolated perfusion setting. In preferred embodiments, IL-3 activity is combined with other cytotoxic activity.
    Type: Grant
    Filed: January 11, 2000
    Date of Patent: December 17, 2002
    Assignee: Crucell Holland B.V.
    Inventors: Marie Elisabeth Draijer-van der Kaaden, Abraham Bout, Dirk Willem van Bekkum
  • Gene therapy of alzheimer's disease by delivery of an encoded apoliprotein E
    Publication number: 20020107213
    Abstract: Gene therapy vehicles to alter the ApoE phenotype of human cells. The ApoE phenotype of the glial cells in the brain is related to the risk of development of dementia such as Alzheimer's disease.
    Type: Application
    Filed: April 16, 2001
    Publication date: August 8, 2002
    Inventors: Stefan Frederik F. Verlinden, Dirk Willem van Bekkum