Patents by Inventor Dirk Zahn

Dirk Zahn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of the receptor GPR86
    Patent number: 7879564
    Abstract: We describe a method of identifying a molecule suitable for the treatment, prophylaxis or alleviation of a GPR86 associated disease, in particular inflammatory disease or pain, the method comprising determining whether a candidate molecule is an agonist or antagonist of GPR86 polypeptide, in which the GPR86 polypeptide comprises the amino acid sequence shown in SEQ ID NO: 3 or SEQ ID NO: 5 or SEQ ID NO: 7, a fragment thereof or a sequence which is at least 90% identical thereto.
    Type: Grant
    Filed: December 21, 2006
    Date of Patent: February 1, 2011
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Nicola Brice, Mark Carlton, John Dixon, Alan Hendrick, Isabelle Malinge, Sophie Messager, Dirk Zahn
  • Use of GPR100 Receptor in Diabetes and Obesity Regulation
    Publication number: 20100311077
    Abstract: We describe a method of identifying a molecule suitable for the treatment, prophylaxis or alleviation of a Gpr100 associated disease, in particular diabetes and obesity, the method comprising determining whether a candidate molecule is an agonist or antagonist of Gpr100 polypeptide, in which the Gpr100 polypeptide comprises the amino acid sequence shown in SEQ ID NO: 3 or SEQ ID NO: 5, or a sequence which is at least 90% identical thereto.
    Type: Application
    Filed: March 16, 2010
    Publication date: December 9, 2010
    Applicant: Takeda Pharmaceutical Company Limited
    Inventors: Samuel Aparicio, John Dixon, Alan Hendrick, Jennifer M. Horwood, Dirk Zahn
  • Ion Channel
    Publication number: 20090187996
    Abstract: The present invention relates to a method of identifying a molecule suitable for the treatment, prophylaxis or alleviation of pain, the method comprising determining whether a candidate molecule is an agonist or antagonist, including a opener, blocker or modulator, of Kv9.2 polypeptide, in which the Kv9.2 polypeptide comprises the amino acid sequence shown in SEQ ID NO:3 or SEQ ID NO:5, or a sequence which is at least 90% identical thereto.
    Type: Application
    Filed: October 29, 2007
    Publication date: July 23, 2009
    Inventors: Nicola Brice, Mark Carlton, John Dixon, Isabelle Malinge, Dirk Zahn
  • Use of Gpr100 receptor in diabetes and obesity regulation
    Publication number: 20080269118
    Abstract: We describe a method of identifying a molecule suitable for the treatment, prophylaxis or alleviation of a Gpr100 associated disease, in particular diabetes and obesity, the method comprising determining whether a candidate molecule is an agonist or antagonist of Gpr100 polypeptide, in which the Gpr100 polypeptide comprises the amino acid sequence shown in SEQ ID NO: 3 or SEQ ID NO: 5, or a sequence which is at least 90% identical thereto.
    Type: Application
    Filed: December 21, 2006
    Publication date: October 30, 2008
    Inventors: Samuel Aparicio, John Dixon, Alan Hendrick, Jennifer Marie Horwood, Dirk Zahn
  • Use of the receptor GPR86
    Publication number: 20070248545
    Abstract: We describe a method of identifying a molecule suitable for the treatment, prophylaxis or alleviation of a GPR86 associated disease, in particular inflammatory disease or pain, the method comprising determining whether a candidate molecule is an agonist or antagonist of GPR86 polypeptide, in which the GPR86 polypeptide comprises the amino acid sequence shown in SEQ ID NO: 3 or SEQ ID NO: 5 or SEQ ID NO: 7, a fragment thereof or a sequence which is at least 90% identical thereto.
    Type: Application
    Filed: December 21, 2006
    Publication date: October 25, 2007
    Inventors: Nicola Brice, Mark Carlton, John Dixon, Alan Hendrick, Isabelle Malinge, Sophie Messager, Dirk Zahn
  • Ion channel
    Publication number: 20070166230
    Abstract: Provided are Kv9.2 polypeptides comprising the amino acid sequence shown in SEQ ID NO. 3 or SEQ ID NO: 5, and homologues, variants and derivatives thereof. Nucleic acids capable of encoding Kv9.2 polypeptide are also disclosed, in particular, those comprising the nucleic acid sequences shown in SEQ ID No. 1, SEQ ID No.2 or SEQ ID NO: 4. Methods of identifying Kv9.2 agonists and antagonists are also provided.
    Type: Application
    Filed: October 30, 2006
    Publication date: July 19, 2007
    Inventors: Nicola Brice, Mark Carlton, John Dixon, Isabelle Malinge, Dirk Zahn
  • Ion channel
    Publication number: 20070101444
    Abstract: Provided are screens for identifying compounds capable of binding to TrpM8 polypeptide. Theses compounds can be antagonists of TrpM8 polypeptide activity. Also provided is a transgenic non-human animal having a functionally disrupted endogenous TrpM8 gene.
    Type: Application
    Filed: September 28, 2006
    Publication date: May 3, 2007
    Inventors: Nicola Brice, John Dixon, Sophie Messager, Dirk Zahn
  • Receptor
    Publication number: 20060242724
    Abstract: The present invention relates to novel functions of a known receptor. In particular, the invention relates to the use of a sphingosylphosphorylcholine receptor and/or ligands thereof in the manipulation of the neuronal and limbic systems and diagnosis and treatment of pain.
    Type: Application
    Filed: March 20, 2006
    Publication date: October 26, 2006
    Inventors: Mark Carlton, John Dixon, Alan Hendrick, Sophie Messager, Dirk Zahn, Jennifer Horwood
  • GPR54 knock-out mammals and screening methods using them
    Publication number: 20060015954
    Abstract: The present invention relates to novel functions of a known receptor. In particular, the invention relates to the use of a galanin-like receptor and/or ligands thereof in the manipulation of the pituitary hormonal axis and reproductive systems.
    Type: Application
    Filed: April 25, 2005
    Publication date: January 19, 2006
    Inventors: Samuel Aparicio, William Colledge, John Dixon, Alan Hendrick, Sophie Messager, Rosemary Thresher, Dirk Zahn
  • Receptor
    Publication number: 20050026825
    Abstract: We disclose Mowgli G-protein coupled receptor (GPCR) polypeptides comprising the amino acid sequence shown in SEQ ID NO: 3, SEQ ID NO: 5, SEQ ID NO: 6 or SEQ ID NO: 8, and homologues, variants and derivatives thereof. Nucleic acids capable of encoding Mowgli polypeptide are also disclosed, in particular, those comprising the nucleic acid sequences shown in SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 4, SEQ ID NO: 7 or SEQ ID NO: 10.
    Type: Application
    Filed: November 14, 2003
    Publication date: February 3, 2005
    Inventors: Mark Carlton, Samuel Aparicio, John Dixon, Rosemary Thresher, Dirk Zahn