Patents by Inventor Divita Mathur

Divita Mathur has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Quantum Dot-Nucleotide Based Ratiometric Fluorescent Molecular Beacon for Quantitative CRISPR/Cas Activity Detection
    Publication number: 20240175076
    Abstract: A flexible strategy for assembling luminescent and colorimetric quantum dot/nucleic acid hairpin (QD-HP) molecular beacons for use in CRISPR/Cas diagnostics uses chimeric peptide/peptide nucleic acid (PNA) to conjugate fluorescently labeled DNA or RNA hairpins to ZnS-coated QDs.
    Type: Application
    Filed: July 5, 2023
    Publication date: May 30, 2024
    Inventors: Sebastián A. Díaz, Christopher M. Green, Joseph R. Spangler, Divita Mathur, Kimihiro Susumu, David A. Stenger, Igor L. Medintz
  • Quantum Dot-Peptide PNA-DNA Complexes as a Platform Reporter System for Multiplexed Detection in Cell-Free Transcription Translation-Based Biosensors
    Publication number: 20240060118
    Abstract: A FRET based reporter system utilizing the fluorescent semiconductor quantum dots (QDs) and restriction enzymes expressed in cell-free system has the potential to detect multiple analytes in single reaction.
    Type: Application
    Filed: May 30, 2023
    Publication date: February 22, 2024
    Inventors: Scott A. Walper, Igor L. Medintz, Divita Mathur, Sebastian A. Diaz, Meghna Thakur, Kimihiro Susumu, Michael H. Stewart
  • Indodicarbocyanine Phosphoramidites with Bathochromically Shifted Absorption and Emission, and Tunable Hydrophobicity
    Publication number: 20230250126
    Abstract: New phosphoramidite Cy5 derivatives can be used in automated DNA synthesis, allowing the labeling of DNA sequences with a wider array of chromophores than are presently commercially available. In addition to varying dye hydrophobicity/hydrophilicity, the 5,5?-substituents (including hexyloxy, triethyleneglycol monomethyl ether, tert-butyl, and chloro groups) can modulate electron donating/withdrawing character while also tuning resulting absorption and emission properties. Modification of the Cy5 periphery enables the tuning of photophysical properties, such as absorption and emission maxima, fluorescence quantum yield, and fluorescence lifetime.
    Type: Application
    Filed: January 27, 2023
    Publication date: August 10, 2023
    Inventors: Igor L. Medintz, Joseph Melinger, William B. Knowlton, Bernard Yurke, Kimihiro Susumu, Sang Ho Lee, Adam Meares, Divita Mathur, Olga A. Mass, Jeunghoon Lee, Ryan D. Pensack