Patents by Inventor Divya Awasthi

Divya Awasthi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230091653
    Abstract: The invention relates to conjugates of biologically active compounds, wherein such a conjugate is comprised of a sequence of amino acids containing a tripeptide that confers selective cleavage by tumor tissue homogenate for release of free drug and/or improves biodistribution into the tumor tissue in comparison to normal tissue homogenate from the same species, wherein the normal tissue is the site of an adverse event associated with administration to a human subject in need thereof of a therapeutically effective amount of a comparator conjugate whose amino acid sequence is a dipeptide known to be selectively cleavable by Cathepsin B.
    Type: Application
    Filed: March 17, 2022
    Publication date: March 23, 2023
    Inventors: Noah BINDMAN, Nicole OKELEY, Peter SENTER, Divya AWASTHI, Vivian TRANG, Ryan LYSKI, Scott JEFFREY, Roozbeh YOUSEFI, Bradley GORSLINE
  • Publication number: 20220144781
    Abstract: The invention provides compounds of formula I: and salts thereof wherein R1-R5 have any of the meanings described in the specification. The compounds are useful for treating bacterial infections (e.g. tuberculosis).
    Type: Application
    Filed: November 2, 2021
    Publication date: May 12, 2022
    Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Joel S. FREUNDLICH, David ALLAND, Matthew B. NEIDITCH, Pradeep KUMAR, Glenn CAPODAGLI, Divya AWASTHI, Sean EKINS
  • Patent number: 11186549
    Abstract: The invention provides compounds of formula (I): and salts thereof wherein R1-R5 have any of the meanings described in the specification. The compounds are useful for treating bacterial infections (e.g. tuberculosis).
    Type: Grant
    Filed: August 29, 2018
    Date of Patent: November 30, 2021
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Joel S. Freundlich, David Alland, Matthew B. Neiditch, Pradeep Kumar, Glenn Capodagli, Divya Awasthi, Sean Ekins
  • Publication number: 20210138077
    Abstract: The invention relates to conjugates of biologically active compounds, wherein such a conjugate is comprised of a sequence of amino acids containing a tripeptide that confers selective cleavage by tumor tissue homogenate for release of free drug and/or improves biodistribution into the tumor tissue in comparison to normal tissue homogenate from the same species, wherein the normal tissue is the site of an adverse event associated with administration to a human subject in need thereof of a therapeutically effective amount of a comparator conjugate whose amino acid sequence is a dipeptide known to be selectively cleavable by Cathepsin B.
    Type: Application
    Filed: September 18, 2020
    Publication date: May 13, 2021
    Inventors: Noah BINDMAN, Nicole OKELEY, Peter SENTER, Divya AWASTHI
  • Publication number: 20200199076
    Abstract: The invention provides compounds of formula (I): and salts thereof wherein R1-R5 have any of the meanings described in the specification. The compounds are useful for treating bacterial infections (e.g. tuberculosis).
    Type: Application
    Filed: August 29, 2018
    Publication date: June 25, 2020
    Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Joel S. FREUNDLICH, David ALLAND, Matthew B. NEIDITCH, Pradeep KUMAR, Glenn CAPODAGLI, Divya AWASTHI, Sean EKINS
  • Patent number: 9845296
    Abstract: The present invention relates to novel 2,5,6-benzimidazole derivatives and pharmaceutically acceptable salts thereof. Another aspect of the invention relates to methods of treating a patient infected by Mycobacterium tuberculosis by administering to the patient a 2,5,6-benzimidazole derivative or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: November 19, 2014
    Date of Patent: December 19, 2017
    Assignee: The Research Foundation for The State University of New York
    Inventors: Iwao Ojima, Divya Awasthi
  • Publication number: 20160297769
    Abstract: The present invention relates to novel 2,5,6-benzimidazole derivatives and pharmaceutically acceptable salts thereof. Another aspect of the invention relates to methods of treating a patient infected by Mycobacterium tuberculosis by administering to the patient a 2,5,6-benzimidazole derivative or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: November 19, 2014
    Publication date: October 13, 2016
    Inventors: Iwao Ojima, Divya Awasthi