Abstract: A query processing device that reduces the calculation cost for checking whether a query complies with restrictions. A query dividing section generates subqueries by dividing an input query for each of a plurality of organizations. A score computing section computes an organization score by evaluating an organization-specific risk that is the risk of determination that the subquery does not comply with organization rules of the organization corresponding to the subquery, on the basis of history information relating to a determination track record resulting from determining, regarding each organization, whether or not the input query complies with the organization rules of each organization. A subquery control section sequentially transmits the subqueries to rule check devices in transmission order according to the organization score, and response information is received regarding the subquery from the rule check devices.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer-storage media, for designing custom applications. In some implementations, a system identifies a predetermined set of application elements that are available to be selectively included in a custom application. The system provides an interface for generating the custom application, wherein the interface includes features to specify each of a plurality of adjustable settings, such that input through the interface can adjust an appearance of the custom application and select which of the predetermined application features are included in the custom application. The system receives input through the interface that specifies settings for the custom application. Based on the input received through the interface, the system generates configuration data for the custom application and updates one or more records to make the custom application available to one or more client devices of one or more users.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer-storage media, for development and deployment of custom applications. In some implementations, configuration data that specifies a configuration of application elements is stored. A repository of modules that are used to implement the respective application elements is stored. A request from a client device over a network is received. User interface data for a view of the custom application is generated. The user interface data for the custom application is provided to the client device over the network in response to the request.

Abstract: To improve resource utilization efficiency of query compliance check, which is check as to whether a query complies with a restriction imposed on data. The query compliance check is roughly divided into data flow policy check as to whether a data flow policy that defines a restriction on data transfer within a county or between countries is complied with, and organization rule check as to whether an organization rule that defines a restriction on sharing outside an organization is complied with, which are hierarchically configured. By analyzing a received query, a system identifies one or more data items as target input/output (I/O) data according to the query, and executes the data flow policy check on the identified one or more data items. When a result of the data flow policy check is false, the system returns a result that the query is compliance violation without executing the organization rule check.

Abstract: Methods and systems for utilizing machine learning to detect the presence of psychological conditions are provided. An example method may involve receiving, at a computing device, an input audio signal and determining, from the input audio signal, (i) acoustic features of the input audio signal, and (ii) a visual representation of the input audio signal. The example method may also involve providing the acoustic features to a first trained neural network; receiving, from the first trained neural network, a first prediction of a psychological condition associated with the input audio signal; providing the visual representation to a second trained neural network; and receiving, from the second trained neural network, a second prediction of the psychological condition associated with the input audio signal. The example method may further involve determining a composite prediction comprising a weighted combination of the first and second prediction and providing the composite prediction.

Abstract: Disclosed herein are isolated follicular helper T cell (TFH) and engineered follicular helper T cell (TFH) and methods of isolating or engineering such cells. Further disclosed herein are methods of using such cells for treating diseases, such as cancer.

Abstract: A method for prevention and/or treatment of diminution of bone tissue using a composition comprising a compound selected from Withaferin A (WFA), Withanolide A, and Withanone. The composition showed enhanced WFA bioavailability in rodents against plain WFA, promotes bone marrow cell differentiation, and increases the percent of bone volume to tissue volume (BV/TV %) by 3 folds as compared to free Withaferin A (WFA).

Abstract: The present invention relates to bioactive fractions and compounds from Dalbergia sissoo for the prevention or treatment of osteo-health related disorders. The present invention relates in the field of pharmaceutical composition that provides new plant extracts, their fractions and pure compound isolated from natural sources that are useful for the prevention and/or treatment of various medical indications associated with estrogen dependent or independent diseases or syndromes or disorders preferably in the prevention or treatment of estrogen dependent or independent diseases or syndromes or disorders caused in humans and animals, and achievement of peak bone mass during skeletal growth and health in humans and animals.

Abstract: A method for prevention and/or treatment of diminution of bone tissue using a composition comprising a compound selected from Withaferin A (WFA), Withanolide A, and Withanone. The composition showed enhanced WFA bioavailability in rodents against plain WFA, promotes bone marrow cell differentiation, and increases the percent of bone volume to tissue volume (BV/TV%) by 3 folds as compared to free Withaferin A (WFA).

Abstract: The present invention relates to novel substituted benzfurochromenes and related compounds having the general formula (I), salts and chiral, achiral derivatives thereof; wherein R1, R2, R3, R4, R5, R6, R7, R8 are independently selected from the groups consisting of hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkoxyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted alkylthio, optionally substituted amino, optionally substituted acylamino, optionally substituted arylamino, optionally substituted acylthio, optionally substituted acyl, optionally substituted aroyl, optionally substituted acyloxy, optionally substituted thioamido, halogens, nitriles, esters, hydroxy, mercapto, carbontrifluoride, nitro but not limited to this; wherein R1R2 or R2R3 or R6R7 may be connected and form either a five membered ring or a six membered ring such as optionally substituted furan, optionally substituted dihydrofuran, optionally substituted

Abstract: The present invention relates to bioactive fractions and compounds from Dalbergia sissoo for the prevention or treatment of osteo-health related disorders. The present invention relates in the field of pharmaceutical composition that provides new plant extracts, their fractions and pure compound isolated from natural sources that are useful for the prevention and/or treatment of various medical indications associated with estrogen dependent or independent diseases or syndromes or disorders preferably in the prevention or treatment of estrogen dependent or independent diseases or syndromes or disorders caused in humans and animals, and achievement of peak bone mass during skeletal growth and health in humans and animals.

Abstract: The present invention relates to novel substituted benzfurochromenes and related compounds having the general formula (I), salts and chiral, achiral derivatives thereof; wherein R1, R2, R3, R4, R5, R6, R7, R8 are independently selected from the groups consisting of hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkoxyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted alkylthio, optionally substituted amino, optionally substituted acylamino, optionally substituted arylamino, optionally substituted acylthio, optionally substituted acyl, optionally substituted aroyl, optionally substituted acyloxy, optionally substituted thioamido, halogens, nitriles, esters, hydroxy, mercapto, carbontrifluoride, nitro but not limited to this; wherein R1R2 or R2R3 or R6R7 may be connected and form either a five membered ring or a six membered ring such as optionally substituted furan, optionally substituted dihydrofuran, optionally substituted

Abstract: Osteoporosis is one of the major problems in our aging society. Osteoporosis results in bone fracture in older members of the population, especially in post-menopausal women. In traditional medicine, there are many natural crude drugs that have the potential for use to treat bone diseases. So far, there is no report in literature on anti-osteoporosis (bone forming) activity of Butea species. It was thought to study the anti-osteoporotic activity of this plant. Thus, the present invention provides a pharmaceutical composition from the extracts of Butea monosperma for prevention or treatment of bone disorders, process of preparation and use thereof.