Patents by Inventor Dmitri B. Kirpotin
Dmitri B. Kirpotin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20160138044Abstract: Provided are novel compositions useful for delivering nucleic acids to cells. Also provided are methods for making and using such compositions.Type: ApplicationFiled: January 22, 2016Publication date: May 19, 2016Inventors: Mark E. Hayes, Dmitri B. Kirpotin
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Publication number: 20160122411Abstract: Provided herein are fusion proteins comprising a first domain that specifically binds to the extracellular domain of a growth factor receptor, and a second domain that specifically binds to a cartilage matrix component, and pharmaceutical composition comprising these fusion proteins. Methods of treating musculoskeletal diseases using the fusion proteins and pharmaceutical composition disclosed herein are also provided.Type: ApplicationFiled: March 28, 2014Publication date: May 5, 2016Applicant: Merrimack Pharmaceuticals, Inc.Inventors: Emily Florine, Dmitri B. Kirpotin, Paul Kopesky, Alexey Lugovskoy, Rachel Rennard, Birait Schoeberl
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Publication number: 20150140069Abstract: Provided herein is a process for preparing a microparticulate complex of a particle-forming component (“PFC”) and a nucleic acid-like component (“NAC”) in a monophasic composition comprising water and a water-miscible organic solvent. Also provided is a microparticulate complex that comprises a particle-forming component complexed to a nucleic acid-like component, and a composition comprising water and the microparticulate complex. Further provided is a method of delivery of a nucleicacid-like component to a cell or to a patient by contacting the cell with or administering to the patient a composition comprising water and the microparticulate complex described herein. Still further, a charge-changing composition represented by the formula A-X—B is provided.Type: ApplicationFiled: September 30, 2014Publication date: May 21, 2015Inventors: Keelung Hong, Wei Wen Zheng, Daryl C. Drummond, Dmitri B. Kirpotin, Mark Eamon Hayes
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Publication number: 20150093328Abstract: The present invention relates to a novel composition useful in targeted diagnostic and/or therapy of a target site, such as cancerous tissue. The composition and methods disclosed herein find particular use in diagnosing and imaging cancerous tissue. The present invention provides a new diagnostic tool for the utilization of positron emission tomography (PET) imaging technique.Type: ApplicationFiled: April 17, 2013Publication date: April 2, 2015Applicant: MERRIMACK PHARMACEUTICALS, INC.Inventors: Daryl C. Drummond, Dmitri B. Kirpotin, Thomas Wickham, Bart S. Hendricks, Samuel Agresta, Helen Lee
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Patent number: 8883200Abstract: Provided herein is a process for preparing a microparticulate complex of a particle-forming component (“PFC”) and a nucleic acid-like component (“NAC”) in a monophasic composition comprising water and a water-miscible organic solvent. Also provided is a microparticulate complex that comprises a particle-forming component complexed to a nucleic acid-like component, and a composition comprising water and the microparticulate complex. Further provided is a method of delivery of a nucleic acid-like component to a cell or to a patient by contacting the cell with or administering to the patient a composition comprising water and the microparticulate complex described herein. Still further, a charge-changing composition represented by the formula A-X—B is provided.Type: GrantFiled: July 11, 2013Date of Patent: November 11, 2014Assignee: Sutter West Bay HospitalsInventors: Keelung Hong, Wei Wen Zheng, Daryl C. Drummond, Dmitri B. Kirpotin, Mark Eamon Hayes
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Publication number: 20140017300Abstract: Provided herein is a process for preparing a microparticulate complex of a particle-forming component (“PFC”) and a nucleic acid-like component (“NAC”) in a monophasic composition comprising water and a water-miscible organic solvent. Also provided is a microparticulate complex that comprises a particle-forming component complexed to a nucleic acid-like component, and a composition comprising water and the microparticulate complex. Further provided is a method of delivery of a nucleic acid-like component to a cell or to a patient by contacting the cell with or administering to the patient a composition comprising water and the microparticulate complex described herein. Still further, a charge-changing composition represented by the formula A-X—B is provided.Type: ApplicationFiled: July 11, 2013Publication date: January 16, 2014Applicant: Sutter West bay Hospital, DBA California Pacific Medical CenterInventors: Keelung Hong, Wei-Wen Zheng, Daryl C. Drummond, Dmitri B. Kirpotin, Mark Eamon Hayes
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Patent number: 8496961Abstract: A process for preparing a microparticulate complex is provided. The process comprises (a) combining a particle-forming component (“PFC”) and a nucleic acid-like component (“NAC”) in a monophasic composition comprising water and a water-miscible, organic solvent to form a mixture wherein the PFC and the NAC are independently molecularly or micellarly soluble in the aqueous/organic solvent system, and (b) reducing the amount of the organic solvent in the mixture. This effects formation of the microparticulate complex of the NAC and the PFC. Also provided is a microparticulate complex that comprises a particle-forming component complexed to a nucleic acid-like component forming an approximately spherical particle, wherein the particle-forming component encloses an interior of the particle containing the nucleic acid-like component and the so-enclosed interior volume has less than about 50% (preferably less than 20%) of the volume containing free water.Type: GrantFiled: May 15, 2003Date of Patent: July 30, 2013Assignee: Sutter West Bay HospitalInventors: Keelung Hong, Wei-Wen Zheng, Daryl C. Drummond, Dmitri B. Kirpotin, Mark Eamon Hayes
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Publication number: 20110104261Abstract: The present invention provides for the development of endocytosis-sensitive probes, and a remote method for measuring cellular endocytosis. These probes are based on the reduced water permeability of a nanoparticle or liposomal delivery system, and inherent degradability or disruption of barrier integrity upon endocytosis. The invention also provides for liposomes having combined therapeutic and diagnostic utilities by co-encapsulating ionically coupled diagnostic and therapeutic agents, in one embodiment, by a method using anionic chelators to prepare electrochemical gradients for loading of amphipathic therapeutic bases into liposomes already encapsulating an imaging agent. The invention provides for imaging of therapeutic liposomes by inserting a lipopolymer anchored, remotely sensing reporter molecules into liposomal lipid layer. The invention allows for an integrated delivery system capable of imaging molecular fingerprints in diseased tissues, treatment, and treatment monitoring.Type: ApplicationFiled: January 7, 2011Publication date: May 5, 2011Inventors: Daryl C. Drummond, Keelung Hong, Dmitri B. Kirpotin
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Publication number: 20100008978Abstract: This invention provides antibodies that have improved affinity for the epidermal growth factor receptor (EGFR). In addition, this invention provides microparticles and nanoparticles comprising a plurality of EGFR affinity moieties that are effectively internalized by cells expressing an EGFR.Type: ApplicationFiled: May 8, 2009Publication date: January 14, 2010Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, HERMES BIOSCIENCES, INC.Inventors: DARYL C. DRUMMOND, DMITRI B. KIRPOTIN, JAMES D. MARKS, YU ZHOU
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Publication number: 20090171077Abstract: A process for preparing a microparticulate complex is provided. The process comprises (a) combining a particle-forming component (“PFC”) and a nucleic acid-like component (“NAC”) in a monophasic composition comprising water and a water-miscible, organic solvent to form a mixture wherein the PFC and the NAC are independently molecularly or micellarly soluble in the aqueous/organic solvent system, and (b) reducing the amount of the organic solvent in the mixture. This effects formation of the microparticulate complex of the NAC and the PFC. Also provided is a microparticulate complex that comprises a particle-forming component complexed to a nucleic acid-like component forming an approximately spherical particle, wherein the particle-forming component encloses an interior of the particle containing the nucleic acid-like component and the so-enclosed interior volume has less than about 50% (preferably less than 20%) of the volume containing free water.Type: ApplicationFiled: March 10, 2009Publication date: July 2, 2009Inventors: Keelung Hong, Wei-Wen Zheng, Daryl C. Drummond, Dmitri B. Kirpotin, Mark Eamon Hayes
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Publication number: 20090155272Abstract: The disclosure pertains to pharmaceuticals, more specifically, to targeted diagnostic and therapeutic formulations and ligands thereof. Such methods and composition comprise antigens that are post-translationally modified compared to antigens found on a normal cell phenotype. Also provided are ligands that bind to such post-translationally modified antigens.Type: ApplicationFiled: September 29, 2006Publication date: June 18, 2009Inventors: John L. Muschler, Dmitri B. Kirpotin, Daryl C. Drummond
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Patent number: 7022336Abstract: The invention provides methods of attaching proteins to lipidic microparticles with efficiencies of at least 77%. The proteins are attached to linker molecules comprising a hydrophilic domain and a hydrophobic domain. The proteins can be antibodies, antibody fragments, hormones, growth factors, enzymes, or nucleic acid binding proteins, or other proteins. The proteins can be chemically conjugated to the linker molecules, or they can be fused to the linker molecules by recombinant techniques.Type: GrantFiled: May 17, 2004Date of Patent: April 4, 2006Assignee: The Regents of the University of CaliforniaInventors: Demetrios Papahadjopoulos, Keelung Hong, Weiwen Zheng, Dmitri B. Kirpotin
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Publication number: 20040209366Abstract: The invention provides methods of attaching proteins to lipidic microparticles with efficiencies of at least 77%. The proteins are attached to linker molecules comprising a hydrophilic domain and a hydrophobic domain. The proteins can be antibodies, antibody fragments, hormones, growth factors, enzymes, or nucleic acid binding proteins, or other proteins. The proteins can be chemically conjugated to the linker molecules, or they can be fused to the linker molecules by recombinant techniques.Type: ApplicationFiled: May 17, 2004Publication date: October 21, 2004Applicant: The Regents of the University of CaliforniaInventors: Demetrios Papahadjopoulos, Keelung Hong, Weiwen Zheng, Dmitri B. Kirpotin
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Patent number: 6803053Abstract: The invention provides lipidic microparticles stably associated with at least two different targeting moieties, which targeting moieties are attached to linker molecules comprising a hydrophilic domain and a hydrophobic domain. The targeting moieties can be antibodies, antibody fragments, hormones, growth factors, enzymes, or nucleic acid binding proteins, or other proteins. The targeting moieties can be chemically conjugated to the linker molecules, or they can be fused by recombinant techniques.Type: GrantFiled: June 21, 2002Date of Patent: October 12, 2004Assignee: The Regents of the University of CaliforniaInventors: Demetrios Papahadjopoulos, Keelung Hong, Weiwen Zheng, Dmitri B. Kirpotin
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Publication number: 20040037874Abstract: A process for preparing a microparticulate complex is provided. The process comprises (a) combining a particle-forming component (“PFC”) and a nucleic acid-like component (“NAC”) in a monophasic composition comprising water and a water-miscible, organic solvent to form a mixture wherein the PFC and the NAC are independently molecularly or micellarly soluble in the aqueous/organic solvent system, and (b) reducing the amount of the organic solvent in the mixture. This effects formation of the microparticulate complex of the NAC and the PFC. Also provided is a microparticulate complex that comprises a particle-forming component complexed to a nucleic acid-like component forming an approximately spherical particle, wherein the particle-forming component encloses an interior of the particle containing the nucleic acid-like component and the so-enclosed interior volume has less than about 50% (preferably less than 20%) of the volume containing free water.Type: ApplicationFiled: May 15, 2003Publication date: February 26, 2004Inventors: Keelung Hong, Wei-Wen Zheng, Daryl C. Drummond, Dmitri B. Kirpotin, Mark Eamon Hayes
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Patent number: 6528087Abstract: The present invention provides for lipid:nucleic acid complexes that have increased shelf life and high transfection activity in vivo following intravenous injection, and methods of preparing such complexes. The methods generally involve contacting a nucleic acid with an organic polycation to produce a condensed nucleic acid, and then combining the condensed nucleic acid with a lipid comprising an amphiphilic cationic lipid to produce the lipid:nucleic acid complex. This complex can be further stabilized by the addition of a hydrophilic polymer attached to hydrophobic side chains. The complex can also be made specific for specific cells, by incorporating a targeting moiety such as an Fab′ fragment attached to a hydrophilic polymer.Type: GrantFiled: January 16, 2001Date of Patent: March 4, 2003Assignee: The Regents of the University of CaliforniaInventors: Demetrios Papahadjopoulos, Keelung Hong, Weiwen Zheng, Dmitri B. Kirpotin
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Publication number: 20030003143Abstract: The present invention provides for lipid:nucleic acid complexes that have increased shelf life and high transfection activity in vivo following intravenous injection, and methods of preparing such complexes. The methods generally involve contacting a nucleic acid with an organic polycation to produce a condensed nucleic acid, and then combining the condensed nucleic acid with a lipid comprising an amphiphilic cationic lipid to produce the lipid:nucleic acid complex. This complex can be further stabilized by the addition of a hydrophilic polymer attached to hydrophobic side chains. The complex can also be made specific for specific cells, by incorporating a targeting moiety such as an Fab′ fragment attached to a hydrophilic polymer.Type: ApplicationFiled: June 21, 2002Publication date: January 2, 2003Applicant: The Regents of the University of CaliforniaInventors: Demetrios Papahadjopoulos, Keelung Hong, Weiwen Zheng, Dmitri B. Kirpotin
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Publication number: 20020001612Abstract: The present invention provides for lipid:nucleic acid complexes that have increased shelf life and high transfection activity in vivo following intravenous injection, and methods of preparing such complexes. The methods generally involve contacting a nucleic acid with an organic polycation to produce a condensed nucleic acid, and then combining the condensed nucleic acid with a lipid comprising an amphiphilic cationic lipid to produce the lipid:nucleic acid complex. This complex can be further stabilized by the addition of a hydrophilic polymer attached to hydrophobic side chains. The complex can also be made specific for specific cells, by incorporating a targeting moiety such as an Fab′ fragment attached to a hydrophilic polymer.Type: ApplicationFiled: January 16, 2001Publication date: January 3, 2002Applicant: The Regents of the University of CaliforniaInventors: Demetrios Papahadjopoulos, Keelung Hong, Weiwen Zheng, Dmitri B. Kirpotin
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Patent number: 6210707Abstract: The present invention provides for lipid:nucleic acid complexes that have increased shelf life and high transfection activity in vivo following intravenous injection, and methods of preparing such complexes. The methods generally involve contacting a nucleic acid with an organic polycation to produce a condensed nucleic acid, and then combining the condensed nucleic acid with a lipid comprising an amphiphilic cationic lipid to produce the lipid:nucleic acid complex. This complex can be further stabilized by the addition of a hydrophilic polymer attached to hydrophobic side chains. The complex can also be made specific for specific cells, by incorporating a targeting moiety such as an Fab′ fragment attached to a hydrophilic polymer.Type: GrantFiled: May 12, 1998Date of Patent: April 3, 2001Assignee: The Regents of the University of CaliforniaInventors: Demetrios Papahadjopoulos, Keelung Hong, Weiwen Zheng, Dmitri B. Kirpotin