Abstract: Systems and methods for determining a treatment regimen for a neoplasm or a cancer are provided. A treatment regimen can be based on the mutational burden of the neoplasm or the cancer. When the mutational burden is high, the treatment regimen can include a drug that targets the cellular processes that protect the neoplasm or cancer in response to mutational burden.

Abstract: Compositions and methods are provided for measuring population size for a plurality of clonal cell populations in the same individual, e.g., for measuring tumor size for a plurality of clonally independent tumors within the same individual. A subject method can include: (a) contacting an individual with a plurality of cell markers that are heritable and distinguishable from one another, to generate a plurality of distinguishable lineages of heritably marked cells; (b) after sufficient time has passed for the heritably marked cells to undergo at least one round of division, detecting and measuring quantities of at least two of the plurality of cell markers present in the contacted tissue, thereby generating a set of measured values: and (c) using the set of measured values to calculate the number of heritably marked cells that are present (e.g., for at least two of the distinguishable lineages of heritably marked cells).

Abstract: Compositions and methods are provided for measuring population size for a plurality of clonal cell populations in the same individual, e.g., for measuring tumor size for a plurality of clonally independent tumors within the same individual. A subject method can include: (a) contacting an individual with a plurality of cell markers that are heritable and distinguishable from one another, to generate a plurality of distinguishable lineages of heritably marked cells; (b) after sufficient time has passed for the heritably marked cells to undergo at least one round of division, detecting and measuring quantities of at least two of the plurality of cell markers present in the contacted tissue, thereby generating a set of measured values; and (c) using the set of measured values to calculate the number of heritably marked cells that are present (e.g., for at least two of the distinguishable lineages of heritably marked cells).

Abstract: Compositions and methods are provided for measuring population size for a plurality of clonal cell populations in the same individual, e.g., for measuring tumor size for a plurality of clonally independent tumors within the same individual. A subject method can include: (a) contacting an individual with a plurality of cell markers that are heritable and distinguishable from one another, to generate a plurality of distinguishable lineages of heritably marked cells; (b) after sufficient time has passed for the heritably marked cells to undergo at least one round of division, detecting and measuring quantities of at least two of the plurality of cell markers present in the contacted tissue, thereby generating a set of measured values; and (c) using the set of measured values to calculate the number of heritably marked cells that are present (e.g., for at least two of the distinguishable lineages of heritably marked cells).

Abstract: Compositions and methods are provided for measuring population size for a plurality of clonal cell populations in the same individual, e.g., for measuring tumor size for a plurality of clonally independent tumors within the same individual. A subject method can include: (a) contacting an individual with a plurality of cell markers that are heritable and distinguishable from one another, to generate a plurality of distinguishable lineages of heritably marked cells; (b) after sufficient time has passed for the heritably marked cells to undergo at least one round of division, detecting and measuring quantities of at least two of the plurality of cell markers present in the contacted tissue, thereby generating a set of measured values; and (c) using the set of measured values to calculate the number of heritably marked cells that are present (e.g., for at least two of the distinguishable lineages of heritably marked cells).

Abstract: Compositions and methods are provided for measuring population size for a plurality of clonal cell populations in the same individual, e.g., for measuring tumor size for a plurality of clonally independent tumors within the same individual. A subject method can include: (a) contacting an individual with a plurality of cell markers that are heritable and distinguishable from one another, to generate a plurality of distinguishable lineages of heritably marked cells; (b) after sufficient time has passed for the heritably marked cells to undergo at least one round of division, detecting and measuring quantities of at least two of the plurality of cell markers present in the contacted tissue, thereby generating a set of measured values; and (c) using the set of measured values to calculate the number of heritably marked cells that are present (e.g., for at least two of the distinguishable lineages of heritably marked cells).

Abstract: Compositions and methods are provided for measuring population size for a plurality of clonal cell populations in the same individual, e.g., for measuring tumor size for a plurality of clonally independent tumors within the same individual. A subject method can include: (a) contacting an individual with a plurality of cell markers that are heritable and distinguishable from one another, to generate a plurality of distinguishable lineages of heritably marked cells; (b) after sufficient time has passed for the heritably marked cells to undergo at least one round of division, detecting and measuring quantities of at least two of the plurality of cell markers present in the contacted tissue, thereby generating a set of measured values; and (c) using the set of measured values to calculate the number of heritably marked cells that are present (e.g., for at least two of the distinguishable lineages of heritably marked cells).

Abstract: In one embodiment, a system includes a database operative to maintain a social graph of an online social network, a leader cache layer, a plurality of servers, and a follower cache layer comprising one or more follower cache clusters, where each follower cache cluster maintains at least a portion of the social graph, and where the follower cache layer is operative to receive a command from the servers with instructions for updating a portion of the social graph, send the command to one of the leader cache layers, receive an acknowledgment of the command from one of the leader cache layers and a request to update; and update one or more of the follower cache clusters storing the portion of the social graph associated with the command.

Abstract: Compositions and methods are provided for measuring population size for a plurality of clonal cell populations in the same individual, e.g., for measuring tumor size for a plurality of clonally independent tumors within the same individual. A subject method can include: (a) contacting an individual with a plurality of cell markers that are heritable and distinguishable from one another, to generate a plurality of distinguishable lineages of heritably marked cells; (b) after sufficient time has passed for the heritably marked cells to undergo at least one round of division, detecting and measuring quantities of at least two of the plurality of cell markers present in the contacted tissue, thereby generating a set of measured values; and (c) using the set of measured values to calculate the number of heritably marked cells that are present (e.g., for at least two of the distinguishable lineages of heritably marked cells).

Abstract: In one embodiment, a system includes a database operative to maintain a social graph of an online social network, a leader cache layer, a plurality of servers, and a follower cache layer comprising one or more follower cache clusters, where each follower cache cluster maintains at least a portion of the social graph, and where the follower cache layer is operative to receive a command from the servers with instructions for updating a portion of the social graph, send the command to one of the leader cache layers, receive an acknowledgment of the command from one of the leader cache layers and a request to update; and update one or more of the follower cache clusters storing the portion of the social graph associated with the command.

Abstract: In one embodiment, a system includes a database; and a cache layer comprising one or more leader cache nodes, the one or more leader cache nodes operative to: communicate graph information between a follower cache layer and the database; receive a request from one of the follower cache nodes to store graph information in the database; update the database storing the graph responsive to the request; and update one or more of the follower cache nodes storing the portion of the graph associated with the request.

Abstract: In one embodiment, a system includes a database; and a cache layer comprising one or more leader cache nodes, the one or more leader cache nodes operative to: communicate graph information between a follower cache layer and the database; receive a request from one of the follower cache nodes to store graph information in the database; update the database storing the graph responsive to the request; and update one or more of the follower cache nodes storing the portion of the graph associated with the request.

Abstract: In one embodiment, a system includes a database; and a cache layer comprising one or more cache nodes, the one or more cache nodes operative to: maintain in a memory one or more data structures storing association information describing associations between nodes in a graph a plurality of distributed cache clusters for storing information in the form of a graph, the graph comprising a plurality of nodes, each uniquely identified by a node identifier, and edge information indicating associations between nodes; respond to queries for associations between nodes in the graph by accessing the memory; and forward other queries to the database for processing.

Abstract: The present invention provides methods and systems for determining a woman's risk of carrying an aneuploid embryo based on the maternal genotype, maternal age and optionally paternal age.

Abstract: In one embodiment, a system includes a database; and a cache layer comprising one or more cache nodes, the one or more cache nodes operative to: maintain in a memory one or more data structures storing association information describing associations between nodes in a graph a plurality of distributed cache clusters for storing information in the form of a graph, the graph comprising a plurality of nodes, each uniquely identified by a node identifier, and edge information indicating associations between nodes; respond to queries for associations between nodes in the graph by accessing the memory; and forward other queries to the database for processing.

Abstract: A distributed caching system for storing and serving information modeled as a graph that includes nodes and edges that define associations or relationships between nodes that the edges connect in the graph.

Abstract: This invention discloses a wireless communications station including a base unit including a communications interface for communicating with plural wireless communications networks, a received communications combiner for combining received communications signals received from the plural wireless communications networks into a single radio frequency output, a transmit communications splitter for splitting previously combined transmit communications signals to be transmitted to the plural wireless communications networks into plural radio frequency outputs, at least one fiberoptic transmitter receiving the single radio frequency output and providing a corresponding optical output, and at least one fiberoptic receiver receiving an optical input and providing an RF output containing previously combined transmit communications signals, a plurality of remote units, each including plural antennas for communicating with communicators along plural wireless communications networks, a received communications splitter fo