Patents by Inventor Dmitri Simberg
Dmitri Simberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11642319Abstract: Methods for intravesical administration of a therapeutic agent including application of a photoactive nanogel to the mucosal surfaces of the bladder and/or intravesical application of cell-penetrating peptides. Photoactive nanogels may be aggregated by exposure to ultraviolet light, either in vitro or in vivo, to provide controlled or extended release of a therapeutic agent, such as an antibiotic.Type: GrantFiled: March 23, 2018Date of Patent: May 9, 2023Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADOInventors: Devatha P. Nair, Dmitri Simberg, Manju Saraswathy
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Publication number: 20200179296Abstract: Click chemistry groups attached to both nanoparticles and antibodies to reduce antibody concentration in the body. The nanoparticles with attached click chemistry groups react with the antibody/biologic attached with a corresponding click chemistry group to sequester it in the liver and spleen, effectively and rapidly decreasing the concentration of free antibody/biologic.Type: ApplicationFiled: December 4, 2019Publication date: June 11, 2020Inventor: Dmitri Simberg
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Publication number: 20200030244Abstract: Methods for intravesical administration of a therapeutic agent including application of a photoactive nanogel to the mucosal surfaces of the bladder and/or intravesical application of cell-penetrating peptides. Photoactive nanogels may be aggregated by exposure to ultraviolet light, either in vitro or in vivo, to provide controlled or extended release of a therapeutic agent, such as an antibiotic.Type: ApplicationFiled: March 23, 2018Publication date: January 30, 2020Inventors: Devatha P. NAIR, Dmitri SIMBERG, Manju SARASWATHY
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Patent number: 9730637Abstract: In alternative embodiments, the invention provides compositions such as devices, pills, beads, capsules, products of manufacture, particles, microparticles, nanoparticles, gels, liquid gels, liquid gel capsules, capsules, tablets, geltabs, liquids, sprays, emulsions, suspensions, pastes or yogurts, for the detection and isolation of biomarkers, nucleic acids, proteins or peptides, proteoglycans, lipids, fats, sugars or polysaccharides in the gastrointestinal tract for e.g., detecting the presence of particular exogenous or endogenous nucleic acids, e.g., DNA or RNA, or proteins, in the gastrointestinal tract, for example, to diagnose the presence of an infectious or exogenous agent such as a virus, a fungus, a parasite, a bacteria, intestinal helminths and protozoan parasites, and the like, or a biomarker such as a cancer-causing or cancer-predisposing allele, e.g., mutations of the KRAS2 oncogene in pancreatic cancer.Type: GrantFiled: August 17, 2012Date of Patent: August 15, 2017Assignee: The Regents of the University of CaliforniaInventors: Dmitri Simberg, Yu-Tsueng Liu
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Patent number: 9101671Abstract: Disclosed are compositions and methods related to clot binding compounds. For example, disclosed are conjugates comprising a surface molecule and a plurality of clot binding compounds. The clot binding compounds can selectively bind to clotted plasma protein. The conjugate can, for example, cause clotting and amplify the accumulation of the conjugate in tumors. In one example, the conjugate can comprise a sufficient number and composition of clot binding compounds such that the conjugate causes clotting and amplifies the accumulation of the conjugate in tumors. The disclosed targeting is useful for treatment of cancer and other diseases and disorders.Type: GrantFiled: December 31, 2007Date of Patent: August 11, 2015Assignee: Sanford-Burnham Medical Research InstituteInventors: Erkki Ruoslahti, Dmitri Simberg
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Publication number: 20140288398Abstract: In alternative embodiments, the invention provides compositions such as devices, pills, beads, capsules, products of manufacture, particles, microparticles, nanoparticles, gels, liquid gels, liquid gel capsules, capsules, tablets, geltabs, liquids, sprays, emulsions, suspensions, pastes or yogurts, for the detection and isolation of biomarkers, nucleic acids, proteins or peptides, proteoglycans, lipids, fats, sugars or polysaccharides in the gastrointestinal tract for e.g., detecting the presence of particular exogenous or endogenous nucleic acids, e.g., DNA or RNA, or proteins, in the gastrointestinal tract, for example, to diagnose the presence of an infectious or exogenous agent such as a virus, a fungus, a parasite, a bacteria, intestinal helminths and protozoan parasites, and the like, or a biomarker such as a cancer-causing or cancer-predisposing allele, e.g., mutations of the KRAS2 oncogene in pancreatic cancer.Type: ApplicationFiled: August 17, 2012Publication date: September 25, 2014Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Dmitri Simberg, Yu-Tsueng Liu
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Publication number: 20140046181Abstract: Techniques, systems, devices and materials are disclosed for implementing and fabricating drug delivery and imaging vehicles, which are activated in the body at a tissue of interest by focused ultrasound. In one aspect, a drug delivery vehicle can include a carrier having an outer membrane that envelopes an acoustic sensitizer particle and a payload substance to be delivered to the target tissue. The outer membrane can protect the acoustic sensitizer particle and the payload substance from degradation and opsonization. The outer membrane can be functionalized with a tumor targeting ligand to cause the drug delivery vehicle to selectively accumulate in a tumor region over other tissues, as well as with an agent to increase circulation time by reducing uptake from undesired body tissues, organs, and systems.Type: ApplicationFiled: January 5, 2012Publication date: February 13, 2014Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Michael Benchimol, Sadik C. Esener, Dmitri Simberg, Stuart Ibsen
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Publication number: 20130202625Abstract: The technology relates in part to methods of preventing and treating diseases and conditions associated with cancer, including methods, compositions, and kits used for preventing and treating cancer dissemination and growth.Type: ApplicationFiled: January 20, 2011Publication date: August 8, 2013Applicant: The Regents Of The University of CalifornaInventors: Dmitri Simberg, Guixin Shi
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Patent number: 8242089Abstract: The present invention concerns the use of a sphingoid-polyalkylamine conjugate comprising a sphingoid backbone carrying, via a carbamoyl bond, at least one polyalkylamine chains as a capturing agent of nucleic acid molecules. The present invention also provides the use of the sphingoid polyalkylamine conjugate for the preparation of a pharmaceutical composition for the delivery of a nucleic acid molecule into a target cell. In a further aspect the invention provides a method for transfecting a nucleic acid into a target cell, the method comprises contacting said target cell with the sphingoid-polyalkylamine conjugate associated with a nucleic acid molecule, thereby transfecting said target cell with said nucleic acid molecule. Other aspects of the invention concern pharmaceutical compositions comprising said conjugate, therapeutic methods as well as kits, making use of the said conjugate. A preferred conjugate according to the invention is N-palmitoyl D-erythrosphingosyl-1-carbamoyl spermine.Type: GrantFiled: June 17, 2004Date of Patent: August 14, 2012Assignee: Yissum Research Development Company of the Hebrew University of JerusalemInventors: Yechezkel Barenholz, Dmitri Simberg
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Publication number: 20100254914Abstract: The disclosure provides elongated nanostructures useful for biological imaging and measurement. More particularly the disclosure provides nanoworms having an increased bioavailability compared to nanospheres.Type: ApplicationFiled: February 25, 2010Publication date: October 7, 2010Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Ji-Ho Park, Lianglin Zhang, Austin M. Derfus, Michael J. Sailor, Geoffrey A. Von Maltzahn, Todd Harris, Sangeeta N. Bhatia, Dmitri Simberg
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Patent number: 7771711Abstract: The present invention concerns novel sphingolipid-polyalkylamines conjugates, a process for their preparation and pharmaceutical compositions comprising the same. In particular, the present invention concerns ceramide based polyalkylamine conjugates and its use as a capturing agent. A preferred ceramide polyalkylamine conjugate is a ceramide-spermine conjugate, more preferably, N-palmitoyl D-erythro sphingosyl-1-carbamoyl spermine.Type: GrantFiled: June 17, 2004Date of Patent: August 10, 2010Assignees: Yissum Research Development Company of The Hebrew University of Jerusalem, Biolab Ltd.Inventors: Yechezkel Barenholz, Dmitri Simberg, Elimelech Rochlin
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Publication number: 20080305101Abstract: Disclosed are compositions and methods related to clot binding compounds. The disclosed targeting is useful for treatment of cancer and other diseases and disorders.Type: ApplicationFiled: December 31, 2007Publication date: December 11, 2008Inventors: Erkki Ruoslahti, Dmitri Simberg
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Publication number: 20080112917Abstract: The present invention concerns novel sphingolipid-polyalkylamines conjugates, a process for their preparation and pharmaceutical compositions comprising the same. In particular, the present invention concerns ceramide based polyalkylamine conjugates and its use as a capturing agent. A preferred ceramide polyalkylamine conjugate is a ceramide-spermine conjugate, more preferably, N-palmitoyl D-erythro sphingosyl-1-carbamoyl spermine.Type: ApplicationFiled: June 17, 2004Publication date: May 15, 2008Applicants: BIOLAB LTD., YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEMInventors: Yechezkel Barenholz, Dmitri Simberg, Elimelech Rochlin
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Publication number: 20060252718Abstract: The present invention concerns the use of a sphingoid-polyalkylamine conjugate comprising a sphingoid backbone carrying, via a carbamoyl bond, at least one polyalkylamine chains as a capturing agent of nucleic acid molecules. The present invention also provides the use of the sphingoid polyalkylamine conjugate for the preparation of a pharmaceutical composition for the delivery of a nucleic acid molecule into a target cell. In a further aspect the invention provides a method for transfecting a nucleic acid into a target cell, the method comprises contacting said target cell with the sphingoid-polyalkylamine conjugate associated with a nucleic acid molecule, thereby transfecting said target cell with said nucleic acid molecule. Other aspects of the invention concern pharmaceutical compositions comprising said conjugate, therapeutic methods as well as kits, making use of the said conjugate. A preferred conjugate according to the invention is N-palmitoyl D-erythrosphingosyl-1-carbamoyl spermine.Type: ApplicationFiled: June 17, 2004Publication date: November 9, 2006Applicant: Yissum Research Development Company of the Hebrew Univeristy of JerusalemInventors: Yechezkel Barenholz, Dmitri Simberg