Abstract: Provided herein are methods of performing force spectroscopy, the methods comprising the steps of providing dielectrophoretic tweezers having at least one set of macroscopic electrodes, at least one of the electrodes having a microfabricated dielectric structure comprising a microwell; depositing force probes on a surface; binding the force probes to molecules on the surface; and applying voltage across set of macroscopic electrodes to thereby manipulate the molecules. Also provided are novel apparatus for performing force spectroscopy, the apparatus comprising dielectrophoretic tweezers having at least one set of macroscopic electrodes, at least one of the electrodes having a microfabricated dielectric structure comprising a microwell.

Abstract: The invention relates to stretch measurements of nucleic acids and correlating those measurements to the extent of double- and single-stranded content of a nucleic acid of interest, and to compositions, systems, and devices related thereto. In preferred embodiments, one performs the stretch or elasticity measurements under conditions such that one can determine a nucleic acid sequence or the presence of an oligonucleotide in a sample.

Abstract: The invention relates to stretch measurements of nucleic acids and correlating those measurements to the extent of double- and single-stranded content of a nucleic acid of interest, and to compositions, systems, and devices related thereto. In preferred embodiments, one performs the stretch or elasticity measurements under conditions such that one can determine a nucleic acid sequence or the presence of an oligonucleotide in a sample.

Abstract: The invention relates to stretch measurements of nucleic acids and correlating those measurements to the extent of double- and single-stranded content of a nucleic acid of interest, and to compositions, systems, and devices related thereto. In preferred embodiments, one performs the stretch or elasticity measurements under conditions such that one can determine a nucleic acid sequence or the presence of an oligonucleotide in a sample.

Abstract: A method and apparatus for initializing an optical recording medium comprising a phase change material using a series of flashes of light. A series of low-power, high duty cycle flashes of light are produced to initialize the media to a crystalline form, onto which data may be recorded. In accordance with another aspect of this invention, a spiral flash bulb with centrally located connectors comprises the flash illumination source for initializing the optical recording media.

Abstract: A method and apparatus for initializing an optical recording medium comprising a phase change material using a series of flashes of light. A series of low-power, high duty cycle flashes of light are produced to initialize the media to a crystalline form, onto which data may be recorded. In accordance with another aspect of this invention, a spiral flash bulb with centrally located connectors comprises the flash illumination source for initializing the optical recording media.

Abstract: A method and apparatus for initializing an optical recording medium comprising a phase change material using a series of flashes of light. A series of low-power, high duty cycle flashes of light are produced to initialize the media to a crystalline form, onto which data may be recorded. In accordance with another aspect of this invention, a spiral flash bulb with centrally located connectors comprises the flash illumination source for initializing the optical recording media.