Patents by Inventor Dmitrii V. Vaviline

Dmitrii V. Vaviline has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Utilization of phosphoketolase in the production of mevalonate, isoprenoid precursors, and isoprene
    Patent number: 10113185
    Abstract: The invention provides for methods for the production of mevalonate, isoprene, isoprenoid precursor molecules, and/or isoprenoids in cells via the heterologous expression of phosphoketolase enzymes.
    Type: Grant
    Filed: September 28, 2016
    Date of Patent: October 30, 2018
    Assignees: Danisco US Inc., The Goodyear Tire & Rubber Company
    Inventors: Zachary Q. Beck, Caroline M. Peres, Dmitrii V. Vaviline, Andrew C. Eliot
  • UTILIZATION OF PHOSPHOKETOLASE IN THE PRODUCTION OF MEVALONATE, ISOPRENOID PRECURSORS, AND ISOPRENE
    Publication number: 20170198311
    Abstract: The invention provides for methods for the production of mevalonate, isoprene, isoprenoid precursor molecules, and/or isoprenoids in cells via the heterologous expression of phosphoketolase enzymes.
    Type: Application
    Filed: September 28, 2016
    Publication date: July 13, 2017
    Inventors: Zachary Q. BECK, Caroline M. PERES, Dmitrii V. VAVILINE, Andrew C. ELIOT
  • Utilization of phosphoketolase in the production of mevalonate, isoprenoid precursors, and isoprene
    Patent number: 9493791
    Abstract: The invention provides for methods for the production of mevalonate, isoprene, isoprenoid precursor molecules, and/or isoprenoids in cells via the heterologous expression of phosphoketolase enzymes.
    Type: Grant
    Filed: February 18, 2015
    Date of Patent: November 15, 2016
    Assignees: Danisco US Inc., The Goodyear Tire & Rubber Company
    Inventors: Zachary Q. Beck, Andrew C. Eliot, Caroline M. Peres, Dmitrii V. Vaviline
  • Increased isoprene production using the archaeal lower mevalonate pathway
    Patent number: 9464301
    Abstract: The invention features methods for producing isoprene from cultured cells using a feedback-resistant mevalonate kinase polypeptide, such as an archaeal mevalonate kinase polypeptide. The resulting isoprene compositions may have increased yields and/or purity of isoprene.
    Type: Grant
    Filed: July 3, 2014
    Date of Patent: October 11, 2016
    Assignees: DANISCO US INC., THE GOODYEAR TIRE & RUBBER COMPANY
    Inventors: Zachary Q. Beck, Anthony R. Calabria, Michael C. Miller, Alex T. Nielsen, Dmitrii V. Vaviline
  • Enhanced production of isoprene using host cells having decreased activity
    Patent number: 9388431
    Abstract: This invention relates to recombinant microorganisms capable of producing isoprene and isoprene production with the use of such recombinant microorganism with good efficiency. In this invention, functional activity of the ispA gene is altered to reduce the production of isoprenoid molecules in recombinant cells engineered to produce isoprene or in cells otherwise susceptible to isoprenoid accumulation during fermentation. This decreased ispA gene functional activity enables enhanced synthesis of isoprene in a host microorganism.
    Type: Grant
    Filed: January 9, 2015
    Date of Patent: July 12, 2016
    Assignees: Danisco US Inc., The Goodyear Tire & Rubber Company
    Inventors: Joseph C. McAuliffe, Rachel E. Muir, Alex T. Nielsen, Caroline M. Peres, Dmitrii V. Vaviline, Derek H. Wells
  • PRODUCTION OF ISOPRENE, ISOPRENOID, AND ISOPRENOID PRECURSORS USING AN ALTERNATIVE LOWER MEVALONATE PATHWAY
    Publication number: 20160002672
    Abstract: The invention provides for compositions and methods for the production of isoprene, isoprenoid precursor, and/or isoprenoids in cells via the expression (e.g., heterologous expression) of phosphomevalonate decarboxylases and/or isopentenyl kinases.
    Type: Application
    Filed: December 20, 2013
    Publication date: January 7, 2016
    Inventors: Zachary Q. BECK, Jörg MAMPEL, Guido MEURER, Michael C. MILLER, Karl J. SANFORD, Dmitrii V. VAVILINE, Walter WEYLER, Gregory M. WHITED
  • UTILIZATION OF PHOSPHOKETOLASE IN THE PRODUCTION OF MEVALONATE, ISOPRENOID PRECURSORS, AND ISOPRENE
    Publication number: 20150225744
    Abstract: The invention provides for methods for the production of mevalonate, isoprene, isoprenoid precursor molecules, and/or isoprenoids in cells via the heterologous expression of phosphoketolase enzymes.
    Type: Application
    Filed: February 18, 2015
    Publication date: August 13, 2015
    Inventors: Zachary Q. BECK, Andrew C. Eliot, Caroline M. Peres, Dmitrii V. Vaviline
  • ENHANCED PRODUCTION OF ISOPRENE USING HOST CELLS HAVING DECREASED ISPA ACTIVITY
    Publication number: 20150218590
    Abstract: This invention relates to recombinant microorganisms capable of producing isoprene and isoprene production with the use of such recombinant microorganism with good efficiency. In this invention, functional activity of the ispA gene is altered to reduce the production of isoprenoid molecules in recombinant cells engineered to produce isoprene or in cells otherwise susceptible to isoprenoid accumulation during fermentation. This decreased ispA gene functional activity enables enhanced synthesis of isoprene in a host microorganism.
    Type: Application
    Filed: January 9, 2015
    Publication date: August 6, 2015
    Inventors: Joseph C. MCAULIFFE, Rachel E. Muir, Alex T. Nielsen, Caroline M. Peres, Dmitrii V. Vaviline, Derek H. Wells
  • INCREASED ISOPRENE PRODUCTION USING THE ARCHAEAL LOWER MEVALONATE PATHWAY
    Publication number: 20150203873
    Abstract: The invention features methods for producing isoprene from cultured cells using a feedback-resistant mevalonate kinase polypeptide, such as an archaeal mevalonate kinase polypeptide. The resulting isoprene compositions may have increased yields and/or purity of isoprene.
    Type: Application
    Filed: July 3, 2014
    Publication date: July 23, 2015
    Inventors: Zachary Q. BECK, Anthony R. CALABRIA, Michael C. MILLER, Alex T. NIELSEN, Dmitrii V. VAVILINE
  • Utilization of phosphoketolase in the production of mevalonate, isoprenoid precursors, and isoprene
    Patent number: 8993305
    Abstract: The invention provides for methods for the production of mevalonate, isoprene, isoprenoid precursor molecules, and/or isoprenoids in cells via the heterologous expression of phosphoketolase enzymes.
    Type: Grant
    Filed: October 5, 2012
    Date of Patent: March 31, 2015
    Assignees: Danisco US Inc., The Goodyear Tire & Rubber Company
    Inventors: Zachary Q. Beck, Andrew C. Eliot, Caroline M. Peres, Dmitrii V. Vaviline
  • Enhanced production of isoprene using host cells having decreased ispA activity
    Patent number: 8975051
    Abstract: This invention relates to recombinant microorganisms capable of producing isoprene and isoprene production with the use of such recombinant microorganism with good efficiency. In this invention, functional activity of the ispA gene is altered to reduce the production of isoprenoid molecules in recombinant cells engineered to produce isoprene or in cells otherwise susceptible to isoprenoid accumulation during fermentation. This decreased ispA gene functional activity enables enhanced synthesis of isoprene in a host microorganism.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: March 10, 2015
    Assignees: Danisco US Inc., The Goodyear Tire & Rubber Company
    Inventors: Joseph C. McAuliffe, Rachel E. Muir, Alex T. Nielsen, Caroline M. Peres, Dmitrii V. Vaviline, Derek H. Wells
  • METHODS FOR INCREASING MICROBIAL PRODUCTION OF ISOPRENE, ISOPRENOIDS, AND ISOPRENOID PRECURSOR MOLECULES USING GLUCOSE AND ACETATE CO-METABOLISM
    Publication number: 20140335576
    Abstract: Provided herein are methods for the increased production of intracellular acetyl-CoA, mevalonate, isoprenoid precursors, isoprene and/or isoprenoids by recombinant microorganisms via co-metabolism of substrates with varied oxidation levels.
    Type: Application
    Filed: May 15, 2014
    Publication date: November 13, 2014
    Applicants: Danisco US Inc., The Goodyear Tire & Rubber Company
    Inventors: Gopal K. CHOTANI, Alex T. NIELSEN, Dmitrii V. VAVILINE
  • Increased isoprene production using the archaeal lower mevalonate pathway
    Patent number: 8815548
    Abstract: The invention features methods for producing isoprene from cultured cells using a feedback-resistant mevalonate kinase polypeptide, such as an archaeal mevalonate kinase polypeptide. The resulting isoprene compositions may have increased yields and/or purity of isoprene.
    Type: Grant
    Filed: December 28, 2012
    Date of Patent: August 26, 2014
    Assignees: Danisco US Inc., The Goodyear Tire & Rubber Company
    Inventors: Zachary Q. Beck, Anthony R. Calabria, Michael C. Miller, Alex T. Nielsen, Dmitrii V. Vaviline
  • ISOPRENE PRODUCTION USING THE DXP AND MVA PATHWAY
    Publication number: 20140162337
    Abstract: The invention provides for methods for producing isoprene from cultured cells using various components of the DXP pathway and MVA pathway, or components associated with the DXP pathway and MVA pathway, iron-sulfur cluster-interacting redox polypeptides, and isoprene synthase. The invention also provides compositions that include these cultured cells.
    Type: Application
    Filed: July 11, 2013
    Publication date: June 12, 2014
    Applicants: The Goodyear Tire & Rubber Company, Danisco US Inc.
    Inventors: Gopal K. CHOTANI, Joseph C. MCAULIFFE, Michael C. MILLER, Rachel E. MUIR, Dmitrii V. VAVILINE, Walter WEYLER
  • INCREASED ISOPRENE PRODUCTION USING THE ARCHAEAL LOWER MEVALONATE PATHWAY
    Publication number: 20130280769
    Abstract: The invention features methods for producing isoprene from cultured cells using a feedback-resistant mevalonate kinase polypeptide, such as an archaeal mevalonate kinase polypeptide. The resulting isoprene compositions may have increased yields and/or purity of isoprene.
    Type: Application
    Filed: December 28, 2012
    Publication date: October 24, 2013
    Inventors: Zachary Q. BECK, Anthony R. CALABRIA, Michael C. MILLER, Alex T. NIELSEN, Dmitrii V. VAVILINE
  • METHODS FOR INCREASING MICROBIAL PRODUCTION OF ISOPRENE, ISOPRENOIDS, AND ISOPRENOID PRECURSOR MOLECULES USING GLUCOSE AND ACETATE CO-METABOLISM
    Publication number: 20130273625
    Abstract: Provided herein are methods for the increased production of intracellular acetyl-CoA, mevalonate, isoprenoid precursors, isoprene and/or isoprenoids by recombinant microorganisms via co-metabolism of substrates with varied oxidation levels.
    Type: Application
    Filed: October 5, 2012
    Publication date: October 17, 2013
    Inventors: Gopal K. CHOTANI, Alex T. NIELSEN, Dmitrii V. VAVILINE
  • Isoprene production using the DXP and MVA pathway
    Patent number: 8507235
    Abstract: The invention provides for methods for producing isoprene from cultured cells using various components of the DXP pathway and MVA pathway, or components associated with the DXP pathway and MVA pathway, iron-sulfur cluster-interacting redox polypeptides, and isoprene synthase. The invention also provides compositions that include these cultured cells.
    Type: Grant
    Filed: June 16, 2010
    Date of Patent: August 13, 2013
    Assignees: Danisco US Inc., The Goodyear Tire & Rubber Company
    Inventors: Gopal K. Chotani, Joseph C. McAuliffe, Michael C. Miller, Rachel E. Muir, Dmitrii V. Vaviline, Walter Weyler
  • UTILIZATION OF PHOSPHOKETOLASE IN THE PRODUCTION OF MEVALONATE, ISOPRENOID PRECURSORS, AND ISOPRENE
    Publication number: 20130089906
    Abstract: The invention provides for methods for the production of mevalonate, isoprene, isoprenoid precursor molecules, and/or isoprenoids in cells via the heterologous expression of phosphoketolase enzymes.
    Type: Application
    Filed: October 5, 2012
    Publication date: April 11, 2013
    Inventors: Zachary Q. BECK, Andrew C. ELIOT, Caroline M. PERES, Dmitrii V. VAVILINE
  • Increased isoprene production using the archaeal lower mevalonate pathway
    Patent number: 8361762
    Abstract: The invention features methods for producing isoprene from cultured cells using a feedback-resistant mevalonate kinase polypeptide, such as an archaeal mevalonate kinase polypeptide. The resulting isoprene compositions may have increased yields and/or purity of isoprene.
    Type: Grant
    Filed: September 15, 2009
    Date of Patent: January 29, 2013
    Assignees: Danisco US Inc., The Goodyear Tire & Rubber Company
    Inventors: Zachary Q. Beck, Anthony R. Calabria, Michael C. Miller, Dmitrii V. Vaviline, Alex T. Nielsen
  • ISOPRENE PRODUCTION USING THE DXP AND MVA PATHWAY
    Publication number: 20110014672
    Abstract: The invention provides for methods for producing isoprene from cultured cells using various components of the DXP pathway and MVA pathway, or components associated with the DXP pathway and MVA pathway, iron-sulfur cluster-interacting redox polypeptides, and isoprene synthase. The invention also provides compositions that include these cultured cells.
    Type: Application
    Filed: June 16, 2010
    Publication date: January 20, 2011
    Inventors: Gopal K. Chotani, Joseph C. Mcauliffe, Michael C. Miller, Rachel Erin Muir, Dmitrii V. Vaviline, Walter Weyler