Abstract: Disclosed are systems, biomarkers, and methods for the diagnosis of Alzheimer's Disease.

Abstract: Methods of obtaining quantitative MRI images of a subject that includes fitting a theoretical model that accounts for tissue-specific relaxation properties and magnetization transfer effects to MRI measured data is disclosed.

Abstract: Disclosed are systems, biomarkers, and methods for the diagnosis of Alzheimer's Disease.

Abstract: Methods of obtaining quantitative MRI images of a subject that includes fitting a theoretical model that accounts for tissue-specific relaxation properties and magnetization transfer effects to MRI measured data is disclosed.

Abstract: Methods of obtaining quantitative MRI images of a subject that includes fitting a theoretical model that accounts for tissue-specific relaxation properties and magnetization transfer effects to MRI measured data is disclosed.

Abstract: An MR method and system of determining elements of the apparent diffusion coefficient tensor in a material with plurality of anisotropic structural units that can be too small to be resolved by direct imaging. MR data is acquired with MR system including pulse sequences, the sequences including imaging or spectroscopy pulse sequences with a series of embedded diffusion-sensitizing gradient waveforms with different gradient strength applied to the material. A nonlinear function of a b-value corresponding to the pulse sequence is defined and the acquired MR data is processed according to defined nonlinear function. Images/maps of the components of the tensor of apparent diffusion coefficients, corresponding to anisotropic structural units, based on the processed MR data, are created. A method of evaluating of the geometrical parameters of lung airways is also described.

Abstract: An MR method and system of determining elements of the apparent diffusion coefficient tensor in a material with plurality of anisotropic structural units that can be too small to be resolved by direct imaging. MR data is acquired with MR system including pulse sequences, the sequences including imaging or spectroscopy pulse sequences with a series of embedded diffusion-sensitizing gradient waveforms with different gradient strength applied to the material. A nonlinear function of a b-value corresponding to the pulse sequence is defined and the acquired MR data is processed according to defined nonlinear function. Images/maps of the components of the tensor of apparent diffusion coefficients, corresponding to anisotropic structural units, based on the processed MR data, are created. A method of evaluating of the geometrical parameters of lung airways is also described.

Abstract: A method and apparatus for acquiring MR images is disclosed. The technique allows rapid acquisition of T2 weighted MR images using gradient echo imaging, and also allows the acquisition of T1 weighted or spin density images, T2* or T2′ weighted images all from the same data set. The technique includes determining a nonlinear function of gradient echo time to offset magnetic field inhomogeneities and acquiring multiple sets of MR data from a series of read-out gradient pulses in a pulse sequence. Both 2-D and 3-D pulse sequence embodiments are disclosed. The MR data is then fit to an equation that includes the nonlinear function and the images are reconstructed that include T1 or spin density weighting, T2 weighting images, T2*, or T2′ weighting. The resulting images are naturally co-registered.