Patents by Inventor Dmitriy Valerievich KORZHAVIN

Dmitriy Valerievich KORZHAVIN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for treatment of an IL-17A-mediated disease through antibody administration specific to human IL-17A
    Patent number: 11447574
    Abstract: The monoclonal IgG-type antibodies were suggested comprising variable domains represented by a combination of VHH-derivative with a variable domain of the light chain VL. Said antibodies can comprise amino acid substitutions at positions 44 and 45 (Kabat numbering) or combinations thereof. Antibodies of the invention possess increased affinity and improved aggregation stability.
    Type: Grant
    Filed: September 9, 2019
    Date of Patent: September 20, 2022
    Inventors: Andrey Borisovich Ulitin, Stanislav Rudolfovich Evdokimov, Valeriy Vladimirovich Soloviev, Yulia Sergeevna Chernykh, Olga Vladimirovna Goncharova, Dmitriy Valerievich Korzhavin, Tatyana Veniaminovna Chernovskaya, Timofey Aleksandrovich Nemankin, Roman Alexeevich Ivanov, Dmitriy Valentinovich Morozov, Victoria Mikhailovna Ekimova, Ekaterina Vladimirovna Sofronova, Yakov Yurevich Ustyugov
  • HIGH AFFINITY AND AGGREGATIVELY STABLE ANTIBODIES ON THE BASIS OF VARIABLE DOMAINS VL AND A DERIVATIVE VHH
    Publication number: 20200031952
    Abstract: The monoclonal IgG-type antibodies were suggested comprising variable domains represented by a combination of VHH-derivative with a variable domain of the light chain VL. Said antibodies can comprise amino acid substitutions at positions 44 and 45 (Kabat numbering) or combinations thereof. Antibodies of the invention possess increased affinity and improved aggregation stability.
    Type: Application
    Filed: September 9, 2019
    Publication date: January 30, 2020
    Inventors: Andrey Borisovich ULITIN, Stanislav Rudolfovich EVDOKIMOV, Valeriy Vladimirovich SOLOVIEV, Yulia Sergeevna CHERNYKH, Olga Vladimirovna GONCHAROVA, Dmitriy Valerievich KORZHAVIN, Tatyana Veniaminovna CHERNOVSKAYA, Timofey Aleksandrovich NEMANKIN, Roman Alexeevich IVANOV, Dmitriy Valentinovich MOROZOV, Victoria Mikhailovna EKIMOVA, Ekaterina Vladimirovna SOFRONOVA, Yakov Yurevich USTYUGOV
  • Anti-IL-17 antibodies
    Patent number: 10442857
    Abstract: The present invention relates to the field of medicine, and specifically to the field of monoclonal antibodies against human IL-17. More specifically, the invention relates to monoclonal antibodies/antagonists of IL-17A, which bind with high affinity to an IL-17 epitope, wherein the antibodies contain amino acid substitutions in hypervariable regions of heavy and light chains. The antibodies according to this invention can be chimeric, humanized or human antibodies or antigen-binding fragments thereof, and can be used as a medicinal agent for treating autoimmune and inflammatory disorders and disorders of cell proliferation and development. The invention also relates to methods for producing said antibodies.
    Type: Grant
    Filed: September 1, 2016
    Date of Patent: October 15, 2019
    Assignee: CLOSED JOINT STOCK COMPANY “BIOCAD”
    Inventors: Andrey Borisovich Ulitin, Stanislav Rudolfovich Evdokimov, Valeriy Vladimirovich Soloviev, Yulia Sergeevna Chernyh, Olga Vladimirovna Goncharova, Dmitriy Valerievich Korzhavin, Tatyana Veniaminovna Chernovskaya, Roman Alexeevich Ivanov, Dmitriy Valentinovich Morozov
  • Anti-IL-17A Antibodies
    Patent number: 10442869
    Abstract: The monoclonal IgG-type antibodies were suggested comprising variable domains represented by a combination of VHH-derivative with a variable domain of the light chain VL. Said antibodies can comprise amino acid substitutions at positions 44 and 45 (Kabat numbering) or combinations thereof. Antibodies of the invention possess increased affinity and improved aggregation stability.
    Type: Grant
    Filed: September 1, 2016
    Date of Patent: October 15, 2019
    Assignee: CLOSED JOINT STOCK COMPANY “BIOCAD”
    Inventors: Andrey Borisovich Ulitin, Stanislav Rudolfovich Evdokimov, Valeriy Vladimirovich Soloviev, Yulia Sergeevna Chernyh, Olga Vladimirovna Goncharova, Dmitriy Valerievich Korzhavin, Tatyana Veniaminovna Chernovskaya, Timofey Aleksandrovich Nemankin, Roman Alexeevich Ivanov, Dmitriy Valentinovich Morozov, Victoria Mikhailovna Ekimova, Ekaterina Vladimirovna Sofronova, Yakov Yurevich Ustyugov
  • ANTI-IL-17 ANTIBODIES, METHOD FOR PRODUCING SAME AND METHOD FOR USING SAME
    Publication number: 20170081401
    Abstract: The present invention relates to the field of medicine, and specifically to the field of monoclonal antibodies against human IL-17. More specifically, the invention relates to monoclonal antibodies/antagonists of IL-17A, which bind with high affinity to an IL-17 epitope, wherein the antibodies contain amino acid substitutions in hypervariable regions of heavy and light chains. The antibodies according to this invention can be chimeric, humanized or human antibodies or antigen-binding fragments thereof, and can be used as a medicinal agent for treating autoimmune and inflammatory disorders and disorders of cell proliferation and development. The invention also relates to methods for producing said antibodies.
    Type: Application
    Filed: September 1, 2016
    Publication date: March 23, 2017
    Inventors: Andrey Borisovich ULITIN, Stanislav Rudolfovich EVDOKIMOV, Valeriy Vladimirovich SOLOVIEV, Yulia Sergeevna CHERNYH, Olga Vladimirovna GONCHAROVA, Dmitriy Valerievich KORZHAVIN, Tatyana Veniaminovna CHERNOVSKAYA, Roman Alexeevich IVANOV, Dmitriy Valentinovich MOROZOV
  • HIGH AFFINITY AND AGGREGATIVELY STABLE ANTIBODIES ON THE BASIS OF VARIABLE DOMAINS VL AND A DERIVATIVE VHH
    Publication number: 20170066843
    Abstract: The monoclonal IgG-type antibodies were suggested comprising variable domains represented by a combination of VHH-derivative with a variable domain of the light chain VL. Said antibodies can comprise amino acid substitutions at positions 44 and 45 (Kabat numbering) or combinations thereof. Antibodies of the invention possess increased affinity and improved aggregation stability.
    Type: Application
    Filed: September 1, 2016
    Publication date: March 9, 2017
    Inventors: Andrey Borisovich ULITIN, Stanislav Rudolfovich EVDOKIMOV, Valeriy Vladimirovich SOLOVIEV, Yulia Sergeevna CHERNYH, Olga Vladimirovna GONCHAROVA, Dmitriy Valerievich KORZHAVIN, Tatyana Veniaminovna CHERNOVSKAYA, Timofey Aleksandrovich NEMANKIN, Roman Alexeevich IVANOV, Dmitriy Valentinovich MOROZOV, Victoria Mikhailovna EKIMOVA, Ekaterina Vladimirovna SOFRONOVA, Yakov Yurevich USTYUGOV