Patents by Inventor Dmitriy Vladimirovich Filippov

Dmitriy Vladimirovich Filippov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for producing an L-amino acid using a bacterium of the enterobacteriaceae family, having attenuated expression of gene(s) encoding peptidase
    Patent number: 8722370
    Abstract: The present invention provides a method for producing L-amino acids, such as L-arginine, L-citrulline, and L-lysine, using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to the genus Escherichia or Pantoea, which has been modified to attenuate expression of one or more genes, such as the pepA, pepB, and pepD genes.
    Type: Grant
    Filed: November 28, 2012
    Date of Patent: May 13, 2014
    Assignee: Ajinomoto Co., Inc.
    Inventors: Dmitriy Vladimirovich Filippov, Tatyana Viktorovna Leonova, Elvira Borisovna Voroshilova, Mikhail Markovich Gusyatiner, Mika Moriya, Yuri Nagai, Keiko Noguchi
  • Method for producing an L-amino acid using a bacterium of the family with attenuated expression of the rcsA gene
    Patent number: 8691537
    Abstract: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of the rcsA gene.
    Type: Grant
    Filed: November 26, 2008
    Date of Patent: April 8, 2014
    Assignee: Ajinomoto Co., Ltd.
    Inventors: Dmitriy Vladimirovich Filippov, Elvira Borisovna Voroshilova, Mikhail Markovich Gusyatiner
  • Method for producing an L-amino acid using a bacterium of the enterobacteriaceae family with attenuated expression of the sfmACDFH-fimZ cluster or the fimZ gene
    Patent number: 8114639
    Abstract: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of the sfmACDFH-fimZ cluster and/or the fimZ gene.
    Type: Grant
    Filed: October 17, 2008
    Date of Patent: February 14, 2012
    Assignee: Ajinomoto Co., Inc.
    Inventors: Dmitriy Vladimirovich Filippov, Vera Georgievna Doroshenko, Aleksandra Yurievna Skorokhodova, Elvira Borisovna Voroshilova, Mikhail Markovich Gusyatiner
  • Method for producing an L-amino acid using a bacterium of the enterobacteriaceae family with attenuated expression of any of the cynT, cynS, cynX or cynR gene or combination thereof
    Patent number: 7919283
    Abstract: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of one or more of the cynT, cynS, cynX and/or cynR genes.
    Type: Grant
    Filed: May 20, 2009
    Date of Patent: April 5, 2011
    Assignee: Ajinomoto Co., Inc.
    Inventors: Dmitriy Vladimirovich Filippov, Elvira Borisovna Voroshilova, Mikhail Markovich Gusyatiner
  • Method for producing an L-amino acid using a bacterium of the family with attenuated expression of the gene
    Patent number: 7888077
    Abstract: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to the genus Escherichia or Pantoea, which has been modified to attenuate expression of the kefB gene.
    Type: Grant
    Filed: November 5, 2007
    Date of Patent: February 15, 2011
    Assignee: Ajinomoto., Inc.
    Inventors: Dmitriy Vladimirovich Filippov, Elvira Borisovna Voroshilova, Mikhail Markovich Gusyatiner
  • Method for producing an L-amino acid using a bacterium of the family by inactivating a gene encoding a toxin of a bacterial toxin-antitoxin pair
    Patent number: 7855060
    Abstract: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging the genus Escherichia or Pantoea, wherein said bacterium has attenuated expression of a gene encoding a toxin of a bacterial toxin-antitoxin pair.
    Type: Grant
    Filed: July 31, 2007
    Date of Patent: December 21, 2010
    Assignee: Ajinomoto Co., Inc.
    Inventors: Dmitriy Vladimirovich Filippov, Elvira Borisovna Voroshilova, Mikhail Markovich Gusyatiner, Konstantin Vyacheslavovich Rybak, Marina Evgenievna Sheremeteva, Aleksandra Yurievna Skorokhodova, Vitaly Grigorievich Paraskevov
  • Method for producing an L-amino acid using a bacterium of the family with attenuated expression of the operon
    Patent number: 7794988
    Abstract: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of the rspAB operon.
    Type: Grant
    Filed: December 30, 2008
    Date of Patent: September 14, 2010
    Assignee: Ajinomoto Co., Inc.
    Inventors: Dmitriy Vladimirovich Filippov, Elvira Borisovna Voroshilova, Mikhail Markovich Gusyatiner
  • METHOD FOR PRODUCING AN L-AMINO ACID USING A BACTERIUM OF ENTEROBACTERIACEAE FAMILY WITH ATTENUATED EXPRESSION OF THE aldH GENE
    Publication number: 20100143982
    Abstract: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to the genus Escherichia or Pantoea, which has been modified to attenuate expression of the aldH gene.
    Type: Application
    Filed: May 23, 2008
    Publication date: June 10, 2010
    Inventors: Dmitriy Vladimirovich Filippov, Elvira Borisovna Voroshilova, Tatyana Viktorovna Leonova, Mikhail Markovich Gusyatiner
  • METHOD FOR PRODUCING AN L-AMINO ACID USING A BACTERIUM OF THE ENTEROBACTERIACEAE FAMILY WITH ATTENUATED EXPRESSION OF ANY OF THE cynT, cynS, cynX OR cynR GENE OR COMBINATION THEREOF
    Publication number: 20090269819
    Abstract: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of one or more of the cynT, cynS, cynX and/or cynR genes.
    Type: Application
    Filed: May 20, 2009
    Publication date: October 29, 2009
    Inventors: Dmitriy Vladimirovich Filippov, Elvira Borisovna Voroshilova, Mikhail Markovich Gusyatiner
  • Method for Producing an L-Amino Acid Using a Bacterium of the Enterobacteriaceae Family With Attenuated Expression of the KefB Gene
    Publication number: 20090226980
    Abstract: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to the genus Escherichia or Pantoea, which has been modified to attenuate expression of the kefB gene.
    Type: Application
    Filed: November 5, 2007
    Publication date: September 10, 2009
    Inventors: Dmitriy Vladimirovich Filippov, Elvira Borisovna Voroshilova, Mikhail Markovich Gusyatiner
  • Method for Producing an L-Amino Acid Using a Bacterium of the Enterobacteriaceae Family Having Attenuated Expression of the nac Gene
    Publication number: 20090197302
    Abstract: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to the genus Escherichia or Pantoea, which has been modified to attenuate expression of the nac gene.
    Type: Application
    Filed: September 4, 2007
    Publication date: August 6, 2009
    Inventors: Dmitriy Vladimirovich Filippov, Elvira Borisovna Voroshilova, Mikhail Markovich Gusyatiner
  • METHOD FOR PRODUCING AN L-AMINO ACID USING A BACTERIUM OF THE ENTEROBACTERIACEAE FAMILY WITH ATTENUATED EXPRESSION OF THE rspAB OPERON
    Publication number: 20090170169
    Abstract: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of the rspAB operon.
    Type: Application
    Filed: December 30, 2008
    Publication date: July 2, 2009
    Inventors: Dmitriy Vladimirovich Filippov, Elvira Borisovna Voroshilova, Mikhail Markovich Gusyatiner
  • METHOD FOR PRODUCING AN L-AMINO ACID USING A BACTERIUM OF THE ENTEROBACTERIACEAE FAMILY WITH ATTENUATED EXPRESSION OF THE rcsA GENE
    Publication number: 20090137011
    Abstract: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of the rcsA gene.
    Type: Application
    Filed: November 26, 2008
    Publication date: May 28, 2009
    Inventors: Dmitriy Vladimirovich Filippov, Elvira Borisovna Voroshilova, Mikhail Markovich Gusyatiner
  • METHOD FOR PRODUCING AN L-AMINO ACID USING A BACTERIUM OF THE ENTEROBACTERIACEAE FAMILY WITH ATTENUATED EXPRESSION OF THE sfmACDFH-fimZ CLUSTER OR THE fimZ GENE
    Publication number: 20090087886
    Abstract: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of the sfmACDFH-fimZ cluster and/or the fimZ gene.
    Type: Application
    Filed: October 17, 2008
    Publication date: April 2, 2009
    Inventors: Dmitriy Vladimirovich Filippov, Vera Georgievna Doroshenko, Aleksandra Yurievna Skorokhodova, Elvira Borisovna Voroshilova, Mikhail Markovich Gusyatiner
  • Method for Producing an L-Amino Acid Using a Bacterium of the Enterobacteriaceae Family Having Expression of the bolA Gene Attenuated
    Publication number: 20090081738
    Abstract: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to the genus Escherichia or Pantoea, which has been modified to attenuate expression of the bolA gene.
    Type: Application
    Filed: July 31, 2007
    Publication date: March 26, 2009
    Inventors: Dmitriy Vladimirovich Filippov, Elvira Borisovna Voroshilova, Tatyana Viktorovna Leonova, Yuri Ivanovich Kozlov, Vitaly Grigorievich Paraskevov
  • Method for Producing an L-Amino Acid Using a Bacterium of the Enterobacteriaceae Family
    Publication number: 20080113416
    Abstract: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging the genus Escherichia or Pantoea, wherein said bacterium has attenuated expression of a gene encoding a toxin of a bacterial toxin-antitoxin pair.
    Type: Application
    Filed: July 31, 2007
    Publication date: May 15, 2008
    Inventors: Dmitriy Vladimirovich Filippov, Elvira Borisovna Voroshilova, Mikhail Markovich Gusyatiner, Konstantin Vyacheslavovich Rybak, Marina Evgenievna Sheremeteva, Aleksandra Yurievna Skorokhodova, Vitaly Grigorievich Paraskevov
  • New mutant glutamine synthetase and method for producing amino acids
    Publication number: 20030148474
    Abstract: Amino acids, such as L-glutamine, L-arginine, L-tryptophan, L-histidine and L-glutamate are produced using a bacterium belonging to the genus Escherichia harboring a mutant glutamine synthetase in which the tyrosine amino acid residue corresponding to position 397 in a wild type glutamine synthetase is replaced with any of amino acid residues, preferably with phenylalanine.
    Type: Application
    Filed: November 20, 2002
    Publication date: August 7, 2003
    Applicant: Ajinomoto Co., Inc.
    Inventors: Mikhail Markovich Gusyatiner, Lirina Valerievna Ivanovskaya, Tatyana Viktorovna Leonova, Ekaterina Igorevna Mukhanova, Yulia Georgievna Rostova, Dmitriy Vladimirovich Filippov, Daria Aleksandrovna Chudakova