Patents by Inventor Dmitry Bandura
Dmitry Bandura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230215714Abstract: Described herein are systems and methods for imaging mass spectrometry, including imaging mass cytometry. Aspects of the subject application include apparatus and methods for imaging mass spectrometry (IMS) that improve speed of sample acquisition, signal sensitivity, and/or signal stability. Systems and methods described herein may minimize the transfer time and/or may minimize the spread of plumes of sample material ablated from a sample to be transferred to the components of the imaging mass spectrometer or mass cytometer that ionize and analyze the sample material.Type: ApplicationFiled: December 21, 2020Publication date: July 6, 2023Applicant: Standard BioTools Canada Inc.Inventors: Adam Carew, Daaf Sandkuijl, Alexander Loboda, Matthew Weel, Dmitry Bandura
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Publication number: 20220155308Abstract: A lyophilized antibody panel is disclosed for interrogation using elemental analysis. The antibody panel includes multiple antibodies each element-tagged or element-labelled with one or more isotopes such that each different antibody is isotopically distinguishable from the other antibodies. Each element tag can include one or more unique isotopes or unique combinations of isotopes. The set of element-tagged antibodies can be lyophilized in admixture. Thus, the lyophilized element-tagged antibody panel can be easily and efficiently resuspended and mixed with a sample prior to interrogation with an elemental analyzer, such as a mass spectrometer. This lyophilized element-tagged antibody panel can provide the benefits of an element-tagged assay while also being easy to use and remaining stable for long durations.Type: ApplicationFiled: March 27, 2020Publication date: May 19, 2022Applicant: Fluidigm Canada Inc.Inventors: Stephen K.H. Li, Daniel Majonis, Vladimir Baranov, Olga Ornatsky, Bedilu Allo, Dmitry Bandura, Colin Thom, Greg Stelzer, Alexander Loboda
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Patent number: 9105457Abstract: A mass analysis system including a sample inlet arranged to introduce a sample and an ion source coupled to the sample inlet and arranged to ionize a portion of the sample into ions. The system also includes a sampler element having a sample orifice arranged to receive the sample ions into a first vacuum chamber. The system includes a skimmer element having a skimmer orifice arranged to receive the sample ions from the first vacuum chamber into a second vacuum chamber where the skimmer orifice is of a first size. The system further includes a third cone element having a third cone orifice of a second size arranged to receive the sample ions from the second vacuum chamber into a third vacuum chamber where the third cone is configured to allow a continuum flow of ions through the third cone orifice. The third chamber includes an ion optics assembly and mass analyzer.Type: GrantFiled: February 23, 2011Date of Patent: August 11, 2015Assignee: PerkinElmer Health Sciences, Inc.Inventors: Hamid R. Badiei, Dmitry Bandura, Vladimir Baranov, Kaveh Kahen, Scott Tanner
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Publication number: 20110253888Abstract: A mass analysis system including a sample inlet arranged to introduce a sample and an ion source coupled to the sample inlet and arranged to ionize a portion of the sample into ions. The system also includes a sampler element having a sample orifice arranged to receive the sample ions into a first vacuum chamber. The system includes a skimmer element having a skimmer orifice arranged to receive the sample ions from the first vacuum chamber into a second vacuum chamber where the skimmer orifice is of a first size. The system further includes a third cone element having a third cone orifice of a second size arranged to receive the sample ions from the second vacuum chamber into a third vacuum chamber where the third cone is configured to allow a continuum flow of ions through the third cone orifice. The third chamber includes an ion optics assembly and mass analyzer.Type: ApplicationFiled: February 23, 2011Publication date: October 20, 2011Applicant: DH Technologies Development PTE. LTD.Inventors: Hamid R. Badiei, Dmitry Bandura, Vladimir Baranov, Kaveh Kahen, Scott Tanner
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Patent number: 7767407Abstract: Methods for the detection and measurement of tagged (labeled) biologically active materials in a sample are described. The tagged biologically active materials are detected using an atomic mass or optical spectrometer having a source of atoms or atomic ions. Element-labeled biologically active materials, comprising antibodies, antibody Fab? fragments, antigens, aptamers, protein complexes, growth factors, hormones, receptors and other biologically active materials attached to a stable elemental tag, can be used in specific binding assays and measured by elemental spectroscopic detection. Also described are methods for the determination of metals in samples of interest using specific antibodies to isolate the target metals and elemental spectroscopy for detection and quantitation. Kits are provided comprising reagents to detect and measure labeled biologically active materials or labeled competition analytes.Type: GrantFiled: October 31, 2007Date of Patent: August 3, 2010Assignee: PerkinElmer Health Sciences, Inc.Inventors: Vladimir Baranov, Scott Tanner, Dmitry Bandura, Zoe Quinn
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Patent number: 7700295Abstract: Methods for the detection and measurement of tagged (labeled) biologically active materials in a sample are described. The tagged biologically active materials are detected using an atomic mass or optical spectrometer having a source of atoms or atomic ions. Element-labeled biologically active materials, comprising antibodies, antibody Fab? fragments, antigens, aptamers, protein complexes, growth factors, hormones, receptors and other biologically active materials attached to a stable elemental tag, can be used in specific binding assays and measured by elemental spectroscopic detection. Also described are methods for the determination of metals in samples of interest using specific antibodies to isolate the target metals and elemental spectroscopy for detection and quantitation. Kits are provided comprising reagents to detect and measure labeled biologically active materials or labeled competition analytes.Type: GrantFiled: July 3, 2003Date of Patent: April 20, 2010Assignee: MDS SCIEXInventors: Vladimir Baranov, Scott Tanner, Dmitry Bandura, Zoe Quinn
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Publication number: 20080176334Abstract: Methods for the detection and measurement of tagged (labeled) biologically active materials in a sample are described. The tagged biologically active materials are detected using an atomic mass or optical spectrometer having a source of atoms or atomic ions. Element-labeled biologically active materials, comprising antibodies, antibody Fab? fragments, antigens, aptamers, protein complexes, growth factors, hormones, receptors and other biologically active materials attached to a stable elemental tag, can be used in specific binding assays and measured by elemental spectroscopic detection. Also described are methods for the determination of metals in samples of interest using specific antibodies to isolate the target metals and elemental spectroscopy for detection and quantitation. Kits are provided comprising reagents to detect and measure labeled biologically active materials or labeled competition analytes.Type: ApplicationFiled: October 31, 2007Publication date: July 24, 2008Applicant: MDS INC., DOING BUSINESS AS MDS SCIEXInventors: Vladimir BARANOV, Scott TANNER, Dmitry BANDURA, Zoe QUINN
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Publication number: 20080046194Abstract: An apparatus for elemental analysis of particles such as single cells or single beads by mass spectrometry is described. The apparatus includes means for particle introduction; means to vaporize, atomize and ionize elements associated with a particle; means to separate the ions according to their mass-to-charge ratio; means to detect the separated ions, means to digitize the output of the means to detect the ions; means to transfer and/or to process and/or record the data output of the means to digitize, having means to detect the presence of a particle in a mass spectrometer; and means to synchronize one of the means for ion detection, data digitization, transfer, processing and recording with the means to detect the presence of a particle. Methods and computer readable code implementing aspects of the apparatus, and for reducing the rates of data generation, digitization, transfer, processing and recording are also described.Type: ApplicationFiled: August 14, 2007Publication date: February 21, 2008Inventors: Alexei Antonov, Dmitry Bandura
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Patent number: 7135296Abstract: Improved methods for the detection and quantitation of labeled biological materials in a sample using elemental spectroscopic detection are described. Element-labeled biologically active materials, comprising antibodies, antigens, growth factors, hormones, receptors and other biologically active materials covalently attached to a stable elemental tag, can be used in specific binding assays and measured by elemental spectroscopic detection. Also described are methods for the determination of metals in samples of interest using specific antibodies to isolate the target metals and elemental spectroscopy for detection and quantitation.Type: GrantFiled: July 17, 2001Date of Patent: November 14, 2006Assignee: MDS Inc.Inventors: Vladimir Baranov, Scott Tanner, Dmitry Bandura, Zoe Quinn
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Publication number: 20050218319Abstract: An apparatus (100) for sequentially analyzing particles such as single cells or single beads, by spectrometry. The apparatus, an elemental flow cytometer, includes means (102) for sequential particle introduction, means (104) to vaporize, atomize and excite or ionize the particles, or an elemental tag associated with an analyte on the particles, and means (106) to analyze the elemental composition of the vaporized, atomized and excited or ionized particles, or an elemental tag associated with the particles. Methods for sequentially analyzing particles such as singe cells or single beads by spectrometry are also described.Type: ApplicationFiled: March 25, 2005Publication date: October 6, 2005Inventors: Dmitry Bandura, Vladimir Baranov, Scott Tanner
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Publication number: 20050032228Abstract: A method of detecting and measuring phosphorus in samples is disclosed. The measurement of phosphorylation is made with an inductively coupled plasma mass spectrometer (ICP-MS), coupled to a reactive collision cell. The reactive collision cell is employed to ensure in inteference-free detection of phosphorus ions, by the: formation of product ions, with a different mass to charge ratio. Accurate Measurement of phosphorylation in samples is important in proteomics.Type: ApplicationFiled: July 17, 2002Publication date: February 10, 2005Inventors: Dmitry Bandura, Vladimir Baranov, Scott Tanner
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Publication number: 20040072250Abstract: Methods for the detection and measurement of tagged (labeled) biologically active materials in a sample are described. The tagged biologically active materials are detected using an atomic mass or optical spectrometer having a source of atoms or atomic ions. Element-labeled biologically active materials, comprising antibodies, antibody Fab′ fragments, antigens, aptamers, protein complexes, growth factors, hormones, receptors and other biologically active materials attached to a stable elemental tag, can be used in specific binding assays and measured by elemental spectroscopic detection. Also described are methods for the determination of metals in samples of interest using specific antibodies to isolate the target metals and elemental spectroscopy for detection and quantitation. Kits are provided comprising reagents to detect and measure labeled biologically active materials or labeled competition analytes.Type: ApplicationFiled: July 3, 2003Publication date: April 15, 2004Applicant: MDS SCIEXInventors: Vladimir Baranov, Scott Tanner, Dmitry Bandura, Zoe Quinn
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Publication number: 20020086441Abstract: Improved methods for the detection and quantitation of labeled biological materials in a sample using elemental spectroscopic detection are described. Element-labeled biologically active materials, comprising antibodies, antigens, growth factors, hormones, receptors and other biologically active materials covalently attached to a stable elemental tag, can be used in specific binding assays and measured by elemental spectroscopic detection. Also described are methods for the determination of metals in samples of interest using specific antibodies to isolate the target metals and elemental spectroscopy for detection and quantitation.Type: ApplicationFiled: July 17, 2001Publication date: July 4, 2002Applicant: MDS SCIEXInventors: Vladimir Baranov, Scott Tanner, Dmitry Bandura, Zoe Quinn