Patents by Inventor Dmitry E. Grinfeld
Dmitry E. Grinfeld has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220246414Abstract: Apparatus and methods for performing charge detection mass spectrometry for measurement of the mass of a single ion of interest are disclosed. The ion of interest is caused to undergo harmonic oscillatory movement in the trapping field of an electrostatic trap, such that an image current detector generates a time-varying signal representative of the ion's oscillatory movement. This time-varying signal (transient) is processed (e.g., via a Fourier transform) to derive the ion's frequency and consequently determine the ion's mass-to-charge ratio (m/z). Ion charge is determined by construction of a Selective Temporal Overview of Resonant Ion (STORI) plot, which tracks the temporal evolution of signals attributable to the ion of interest, and where the slope of the STORI plot is related to the charge. The STORI plot may also be employed to identify ion decay events during transient acquisition and/or the presence of multiple ions of the same mass or non-resolvable ions.Type: ApplicationFiled: April 22, 2020Publication date: August 4, 2022Inventors: Michael W. SENKO, Ping F. YIP, Dmitry E. GRINFELD, Steven C. BEU
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Patent number: 11387094Abstract: A time-of-flight (ToF) mass spectrometer, comprising: a pulsed ion injector for forming an ion beam that travels along an ion path; a detector for detecting ions in the ion beam that arrive at the detector at times according to their m/z values; an ion focusing arrangement located between the ion injector and the detector for focusing the ion beam in at least one direction orthogonal to the ion path; and a variable voltage supply for supplying the ion focusing arrangement with at least one variable voltage that is dependent on a charge state and/or an amount of ions of at least one species of ions in the ion beam. A corresponding method of mass spectrometry is provided. The charge state and/or an amount of ions may be acquired from a pre-scan, or predicted. Tuning of the spectrometer based on a charge state and/or an amount of ions of at least one species of ions in the ion beam may be performed on the fly.Type: GrantFiled: March 2, 2021Date of Patent: July 12, 2022Assignee: Thermo Fisher Scientific (Bremen) GmbHInventors: Hamish Stewart, Dmitry E. Grinfeld, Alexander A. Makarov
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Publication number: 20210272790Abstract: A time-of-flight (ToF) mass spectrometer, comprising: a pulsed ion injector for forming an ion beam that travels along an ion path; a detector for detecting ions in the ion beam that arrive at the detector at times according to their m/z values; an ion focusing arrangement located between the ion injector and the detector for focusing the ion beam in at least one direction orthogonal to the ion path; and a variable voltage supply for supplying the ion focusing arrangement with at least one variable voltage that is dependent on a charge state and/or an amount of ions of at least one species of ions in the ion beam. A corresponding method of mass spectrometry is provided. The charge state and/or an amount of ions may be acquired from a pre-scan, or predicted. Tuning of the spectrometer based on a charge state and/or an amount of ions of at least one species of ions in the ion beam may be performed on the fly.Type: ApplicationFiled: March 2, 2021Publication date: September 2, 2021Inventors: Hamish Stewart, Dmitry E. Grinfeld, Alexander A. Makarov
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Patent number: 10964520Abstract: A multi-reflection mass spectrometer comprising two ion mirrors spaced apart and opposing each other in a direction X, each mirror elongated generally along a drift direction Y, the drift direction Y being orthogonal to the direction X, a pulsed ion injector for injecting pulses of ions into the space between the ion mirrors, the ions entering the space at a non-zero inclination angle to the X direction, the ions thereby forming an ion beam that follows a zigzag ion path having N reflections between the ion mirrors in the direction X whilst drifting along the drift direction Y, a detector for detecting ions after completing the same number N of reflections between the ion mirrors, and an ion focusing arrangement at least partly located between the opposing ion mirrors and configured to provide focusing of the ion beam in the drift direction Y, such that a spatial spread of the ion beam in the drift direction Y passes through a single minimum at or immediately after a reflection having a number between 0.Type: GrantFiled: November 27, 2019Date of Patent: March 30, 2021Assignee: Thermo Fisher Scientific (Bremen) GmbHInventors: Hamish Stewart, Dmitry E. Grinfeld, Alexander A. Makarov
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Publication number: 20200243322Abstract: A multi-reflection mass spectrometer comprising two ion mirrors spaced apart and opposing each other in a direction X, each mirror elongated generally along a drift direction Y, the drift direction Y being orthogonal to the direction X, a pulsed ion injector for injecting pulses of ions into the space between the ion mirrors, the ions entering the space at a non-zero inclination angle to the X direction, the ions thereby forming an ion beam that follows a zigzag ion path having N reflections between the ion mirrors in the direction X whilst drifting along the drift direction Y, a detector for detecting ions after completing the same number N of reflections between the ion mirrors, and an ion focusing arrangement at least partly located between the opposing ion mirrors and configured to provide focusing of the ion beam in the drift direction Y, such that a spatial spread of the ion beam in the drift direction Y passes through a single minimum at or immediately after a reflection having a number between 0.Type: ApplicationFiled: November 27, 2019Publication date: July 30, 2020Inventors: Hamish Stewart, Dmitry E. Grinfeld, Alexander A. Makarov
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Patent number: 10510525Abstract: An apparatus for separating ions includes an electrode arrangement having a length extending between first and second ends. The first end is configured to introduce a beam of ions into an ion transmission space of the arrangement. An electronic controller applies an RF potential and a DC potential to an electrode of the electrode arrangement, for generating a ponderomotive RF electric field and a mass-independent DC electric field. The application of the potentials is controlled such that a ratio of the strength of the ponderomotive RF electric field to the strength of the mass-independent DC electric field varies along the length of the electrode arrangement. The generated electric field supports extraction of ions having different m/z values at respective different positions along the length of the electrode arrangement. Ions are extracted in one of increasing and decreasing sequential order of m/z ratio with increasing distance from the first end.Type: GrantFiled: January 10, 2019Date of Patent: December 17, 2019Assignees: Thermo Fisher Scientific (Bremen) GmbH, Thermo Finnigan LLCInventors: Dmitry E. Grinfeld, Mikhail V. Ugarov, Viatcheslav V. Kovtoun, Alexander A. Makarov
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Publication number: 20190164738Abstract: An apparatus for separating ions includes an electrode arrangement having a length extending between first and second ends. The first end is configured to introduce a beam of ions into an ion transmission space of the arrangement. An electronic controller applies an RF potential and a DC potential to an electrode of the electrode arrangement, for generating a ponderomotive RF electric field and a mass-independent DC electric field. The application of the potentials is controlled such that a ratio of the strength of the ponderomotive RF electric field to the strength of the mass-independent DC electric field varies along the length of the electrode arrangement. The generated electric field supports extraction of ions having different m/z values at respective different positions along the length of the electrode arrangement. Ions are extracted in one of increasing and decreasing sequential order of m/z ratio with increasing distance from the first end.Type: ApplicationFiled: January 10, 2019Publication date: May 30, 2019Inventors: Dmitry E. GRINFELD, Mikhail V. UGAROV, Viatcheslav V. KOVTOUN, Alexander A. MAKAROV
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Patent number: 10199208Abstract: An apparatus for separating ions includes an electrode arrangement having a length extending between first and second ends. The first end is configured to introduce a beam of ions into an ion transmission space of the arrangement. An electronic controller applies an RF potential and a DC potential to an electrode of the electrode arrangement, for generating a ponderomotive RF electric field and a mass-independent DC electric field. The application of the potentials is controlled such that a ratio of the strength of the ponderomotive RF electric field to the strength of the mass-independent DC electric field varies along the length of the electrode arrangement. The generated electric field supports extraction of ions having different m/z values at respective different positions along the length of the electrode arrangement. Ions are extracted in one of increasing and decreasing sequential order of m/z ratio with increasing distance from the first end.Type: GrantFiled: March 3, 2016Date of Patent: February 5, 2019Assignees: Thermo Finnigan LLC, Thermo Fisher Scientific (Bremen) GmbHInventors: Dmitry E. Grinfeld, Mikhail V. Ugarov, Viatcheslav V. Kovtoun, Alexander A. Makarov
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Publication number: 20170256389Abstract: An apparatus for separating ions includes an electrode arrangement having a length extending between first and second ends. The first end is configured to introduce a beam of ions into an ion transmission space of the arrangement. An electronic controller applies an RF potential and a DC potential to an electrode of the electrode arrangement, for generating a ponderomotive RF electric field and a mass-independent DC electric field. The application of the potentials is controlled such that a ratio of the strength of the ponderomotive RF electric field to the strength of the mass-independent DC electric field varies along the length of the electrode arrangement. The generated electric field supports extraction of ions having different m/z values at respective different positions along the length of the electrode arrangement. Ions are extracted in one of increasing and decreasing sequential order of m/z ratio with increasing distance from the first end.Type: ApplicationFiled: March 3, 2016Publication date: September 7, 2017Inventors: Dmitry E. GRINFELD, Mikhail V. UGAROV, Viatcheslav V. KOVTOUN, Alexander A. MAKAROV
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Patent number: 9620350Abstract: A method of reflecting ions in a multireflection time of flight mass spectrometer is disclosed. The method includes guiding ions toward an ion mirror having multiple electrodes, and applying a voltage to the ion mirror electrodes to create an electric field that causes the mean trajectory of the ions to intersect a plane of symmetry of the ion mirror and to exit the ion mirror, wherein the ion are spatially focussed by the mirror to a first location and temporally focused to a second location different from the first location. Apparatus for carrying out the method is also disclosed.Type: GrantFiled: April 18, 2016Date of Patent: April 11, 2017Assignee: Thermo Fisher Scientific (Bremen) GmbHInventors: Alexander A. Makarov, Dmitry E. Grinfeld, Mikhail A. Monastyrskiy
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Publication number: 20160233076Abstract: A method of reflecting ions in a multireflection time of flight mass spectrometer is disclosed. The method includes guiding ions toward an ion mirror having multiple electrodes, and applying a voltage to the ion mirror electrodes to create an electric field that causes the mean trajectory of the ions to intersect a plane of symmetry of the ion mirror and to exit the ion mirror, wherein the ion are spatially focussed by the mirror to a first location and temporally focused to a second location different from the first location. Apparatus for carrying out the method is also disclosed.Type: ApplicationFiled: April 18, 2016Publication date: August 11, 2016Inventors: Alexander A. MAKAROV, Dmitry E. GRINFELD, Mikhail A. MONASTYRSKIY
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Patent number: 9324553Abstract: A method of reflecting ions in a multireflection time of flight mass spectrometer is disclosed. The method includes guiding ions toward an ion mirror having multiple electrodes, and applying a voltage to the ion mirror electrodes to create an electric field that causes the mean trajectory of the ions to intersect a plane of symmetry of the ion mirror and to exit the ion mirror, wherein the ion are spatially focussed by the mirror to a first location and temporally focused to a second location different from the first location. Apparatus for carrying out the method is also disclosed.Type: GrantFiled: June 24, 2015Date of Patent: April 26, 2016Assignee: Thermo Fisher Scientific (Bremen) GmbHInventors: Alexander A. Makarov, Dmitry E. Grinfeld, Mikhail A. Monastyrskiy
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Publication number: 20150294849Abstract: A method of reflecting ions in a multireflection time of flight mass spectrometer is disclosed. The method includes guiding ions toward an ion mirror having multiple electrodes, and applying a voltage to the ion mirror electrodes to create an electric field that causes the mean trajectory of the ions to intersect a plane of symmetry of the ion mirror and to exit the ion mirror, wherein the ion are spatially focussed by the mirror to a first location and temporally focused to a second location different from the first location. Apparatus for carrying out the method is also disclosed.Type: ApplicationFiled: June 24, 2015Publication date: October 15, 2015Inventors: Alexander A. MAKAROV, Dmitry E. GRINFELD, Mikhail A. MONASTYRSKIY
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Patent number: 9082605Abstract: A method of reflecting ions in a multireflection time of flight mass spectrometer is disclosed. The method includes guiding ions toward an ion mirror having multiple electrodes, and applying a voltage to the ion mirror electrodes to create an electric field that causes the mean trajectory of the ions to intersect a plane of symmetry of the ion mirror and to exit the ion mirror, wherein the ion are spatially focussed by the mirror to a first location and temporally focused to a second location different from the first location. Apparatus for carrying out the method is also disclosed.Type: GrantFiled: August 2, 2013Date of Patent: July 14, 2015Assignee: Thermo Fisher Scientific (Bremen) GmbHInventors: Alexander A. Makarov, Dmitry E. Grinfeld, Mikhail A. Monastyrskiy
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Patent number: 8674293Abstract: A method of reflecting ions in a multireflection time of flight mass spectrometer is disclosed. The method includes guiding ions toward an ion mirror having multiple electrodes, and applying a voltage to the ion mirror electrodes to create an electric field that causes the mean trajectory of the ions to intersect a plane of symmetry of the ion mirror and to exit the ion mirror, wherein the ion are spatially focussed by the mirror to a first location and temporally focused to a second location different from the first location. Apparatus for carrying out the method is also disclosed.Type: GrantFiled: March 8, 2013Date of Patent: March 18, 2014Assignee: Thermo Fisher Scientific (Bremen) GmbHInventors: Alexander A. Makarov, Dmitry E. Grinfeld, Mikhail A. Monastyrskiy
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Publication number: 20130313424Abstract: A method of reflecting ions in a multireflection time of flight mass spectrometer is disclosed. The method includes guiding ions toward an ion mirror having multiple electrodes, and applying a voltage to the ion mirror electrodes to create an electric field that causes the mean trajectory of the ions to intersect a plane of symmetry of the ion mirror and to exit the ion mirror, wherein the ion are spatially focussed by the mirror to a first location and temporally focused to a second location different from the first location. Apparatus for carrying out the method is also disclosed.Type: ApplicationFiled: August 2, 2013Publication date: November 28, 2013Inventors: Alexander A. MAKAROV, Dmitry E. GRINFELD, Mikhail A. MONASTYRSKIY
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Patent number: 8546754Abstract: An ion trap comprises substantially elongate electrodes 10, 20 some of which are curved along their axis of elongation and which define a trapping volume between them. The sectional area of this trapping volume towards the extremities of the trap in the direction of elongation is different to the sectional area away from its extremities (eg towards the middle of the trap). In a preferred embodiment, the trap has a plurality of elongate electrodes, wherein opposed electrodes have different radii of curvature so that the trap splays towards its extremities. Thereby, a wider mass range of ions can be trapped and ejected, a higher space charge capacity (for a given trap length) is provided, and sharper ion beam focussing on ejection is possible.Type: GrantFiled: August 5, 2011Date of Patent: October 1, 2013Assignee: Thermo Fisher Scientific (Bremen) GmbHInventors: Alexander A. Makarov, Mikhail A. Monastyrskiy, Dmitry E. Grinfeld
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Publication number: 20110284737Abstract: An ion trap comprises substantially elongate electrodes 10, 20 some of which are curved along their axis of elongation and which define a trapping volume between them. The sectional area of this trapping volume towards the extremities of the trap in the direction of elongation is different to the sectional area away from its extremities (eg towards the middle of the trap). In a preferred embodiment, the trap has a plurality of elongate electrodes, wherein opposed electrodes have different radii of curvature so that the trap splays towards its extremities. Thereby, a wider mass range of ions can be trapped and ejected, a higher space charge capacity (for a given trap length) is provided, and sharper ion beam focussing on ejection is possible.Type: ApplicationFiled: August 5, 2011Publication date: November 24, 2011Inventors: Alexander MAKAROV, Mikhail A. MONASTYRSKIY, Dmitry E. GRINFELD
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Patent number: 8017909Abstract: An ion trap comprises substantially elongate electrodes 10, 20 some of which are curved along their axis of elongation and which define a trapping volume between them. The sectional area of this trapping volume towards the extremities of the trap in the direction of elongation is different to the sectional area away from its extremities (eg towards the middle of the trap). In a preferred embodiment, the trap has a plurality of elongate electrodes, wherein opposed electrodes have different radii of curvature so that the trap splays towards its extremities. Thereby, a wider mass range of ions can be trapped and ejected, a higher space charge capacity (for a given trap length) is provided, and sharper ion beam focussing on ejection is possible.Type: GrantFiled: December 27, 2007Date of Patent: September 13, 2011Assignee: Thermo Fisher Scientific (Bremen) GmbHInventors: Alexander Makarov, Mikhail A Monastyrskiy, Dmitry E. Grinfeld
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Publication number: 20100320376Abstract: An ion trap comprises substantially elongate electrodes 10, 20 some of which are curved along their axis of elongation and which define a trapping volume between them. The sectional area of this trapping volume towards the extremities of the trap in the direction of elongation is different to the sectional area away from its extremities (eg towards the middle of the trap). In a preferred embodiment, the trap has a plurality of elongate electrodes, wherein opposed electrodes have different radii of curvature so that the trap splays towards its extremities. Thereby, a wider mass range of ions can be trapped and ejected, a higher space charge capacity (for a given trap length) is provided, and sharper ion beam focussing on ejection is possible.Type: ApplicationFiled: December 27, 2007Publication date: December 23, 2010Inventors: Alexander Makarov, Mikhail A. Monastyrskiy, Dmitry E. Grinfeld