Patents by Inventor Dmitry Fradkin
Dmitry Fradkin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240127540Abstract: A method of aligning images for 3D imaging of a sample includes, for each of multiple cameras located around a vessel, activating a respective light source that provides backlighting for the vessel, and capturing a respective 2D calibration image of the vessel. The method also includes, for each 2D calibration image, measuring a respective vertical position, horizontal position, and rotation of the image, in part by detecting edges of the vessel as depicted in the image. The method also includes generating calibration data based on the measured vertical positions, horizontal positions, and rotations for the respective 2D calibration images, capturing, by each camera, a respective set of 2D images of the sample in the vessel, and digitally resampling, using the calibration data, at least one of the respective sets of 2D images to correct for vertical offset, horizontal offset, and rotational offset of the set(s) of 2D images.Type: ApplicationFiled: December 27, 2023Publication date: April 18, 2024Inventors: Graham F. Milne, Dmitry Fradkin, Thomas Clark Pearson
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Patent number: 11900540Abstract: A method for 3D imaging of a sample, in a vessel having a longitudinal axis orthogonal to a horizontal plane, includes capturing, by at least three cameras located at different positions around the vessel, respective 2D images of the sample. Each image comprises pixels having associated pixel values. The optical axis of a first camera is inclined or declined at a first angle relative to the horizontal plane, with the first angle being greater than or equal to zero degrees. The optical axis of a second camera is inclined or declined at a second, larger angle relative to the horizontal plane. The method also includes generating a 3D image of the sample based on the pixel values associated with the 2D image pixels, and one or more look-up tables that collectively indicate, for pixels in each image, expected paths for light traversing the vessel and the sample.Type: GrantFiled: June 2, 2020Date of Patent: February 13, 2024Assignee: AMGEN INC.Inventors: Graham F. Milne, Dmitry Fradkin, Thomas Clark Pearson
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Patent number: 11874233Abstract: In a method for imaging a container holding a sample, the container is illuminated with a laser sheet of a first color, and one or more images of the container are capturing by a first imager configured to filter out colors other than the first color. Simultaneously with illuminating the container with the laser sheet of the first color, the container is illuminated with light of a second color different than the first color, wherein the light of the second color illuminates at least a majority of an entire volume of the container. One or more additional imagers of the container are captured by a second imager configured to filter out colors other than the second color. The one or more images and the one or more additional images are analyzed to detect particles within, and/or on an exterior surface of, the container.Type: GrantFiled: December 27, 2022Date of Patent: January 16, 2024Assignee: AMGEN INC.Inventors: Thomas Clark Pearson, Graham F. Milne, Dmitry Fradkin, Erwin Freund
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Publication number: 20230398577Abstract: A robotic inspection platform comprises a robotic arm, an imager, and a controller. The controller causes the robotic arm to retrieve, using its end effector, a container, and to manipulate the container such that the container is sequentially placed in a plurality of orientations while in view of the imager. The controller also causes the imager to capture images, with each of the images being captured while the container is in a respective one of the orientations. The controller also determines one or more attributes of the container, and/or a sample within the container, by analyzing the images using a pattern recognition model and, based on the attribute(s), determines whether the container and/or sample satisfies one or more criteria. If the container and/or sample fails to satisfy the criteria, the controller causes the robotic arm to place the container in an area (e.g., bin) reserved for rejected containers and/or samples.Type: ApplicationFiled: August 18, 2023Publication date: December 14, 2023Inventors: Dmitry Fradkin, Thomas Clark Pearson, Neelima Chavali, Erwin Freund
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Patent number: 11766700Abstract: A robotic inspection platform comprises a robotic arm, an imager, and a controller. The controller causes the robotic arm to retrieve, using its end effector, a container, and to manipulate the container such that the container is sequentially placed in a plurality of orientations while in view of the imager. The controller also causes the imager to capture images, with each of the images being captured while the container is in a respective one of the orientations. The controller also determines one or more attributes of the container, and/or a sample within the container, by analyzing the images using a pattern recognition model and, based on the attribute(s), determines whether the container and/or sample satisfies one or more criteria. If the container and/or sample fails to satisfy the criteria, the controller causes the robotic arm to place the container in an area (e.g., bin) reserved for rejected containers and/or samples.Type: GrantFiled: June 12, 2019Date of Patent: September 26, 2023Assignee: AMGEN INC.Inventors: Dmitry Fradkin, Thomas C. Pearson, Neelima Chavali, Erwin Freund
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Publication number: 20230139131Abstract: In a method for imaging a container holding a sample, the container is illuminated with a laser sheet of a first color, and one or more images of the container are capturing by a first imager configured to filter out colors other than the first color. Simultaneously with illuminating the container with the laser sheet of the first color, the container is illuminated with light of a second color different than the first color, wherein the light of the second color illuminates at least a majority of an entire volume of the container. One or more additional imagers of the container are captured by a second imager configured to filter out colors other than the second color. The one or more images and the one or more additional images are analyzed to detect particles within, and/or on an exterior surface of, the container.Type: ApplicationFiled: December 27, 2022Publication date: May 4, 2023Inventors: Thomas Clark Pearson, Graham F. Milne, Dmitry Fradkin, Erwin Freund
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Patent number: 11592403Abstract: In a method for imaging a container holding a sample, the container is illuminated with a laser sheet that impinges upon the container in a first direction corresponding to a first axis. A plane of the laser sheet is defined by the first axis and a second axis orthogonal to the first axis. The method also includes capturing, by a camera having an imaging axis that is substantially orthogonal to at least the first axis, an image of the container. The method further includes analyzing, by one or more processors, the image of the container to detect particles within, and/or on an exterior surface of, the container.Type: GrantFiled: December 16, 2019Date of Patent: February 28, 2023Assignee: AMGEN INC.Inventors: Thomas Clark Pearson, Graham F. Milne, Dmitry Fradkin, Erwin Freund
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Publication number: 20230027008Abstract: Assemblies (10), devices, and methods are described herein that allow an examiner to inspect a container (12) of liquid product (14) through a bottom wall (18) of the container using a line-of-sight diversion member (28, e.g. beam splitter, mirror or prism). In some forms, the assemblies described herein can be provided with mounts and connecting arms to couple the devices to inspection booths.Type: ApplicationFiled: December 17, 2020Publication date: January 26, 2023Inventors: Graham F. Milne, Dmitry Fradkin
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Publication number: 20230004591Abstract: A computer-implemented method, computer program product, and a technical system for generating triples including providing a plurality of log entries from respective log files, wherein each log entry of the plurality of log entries includes at least one text message, generating at least one template based on the plurality of log entries using unsupervised clustering, wherein the at least one template includes at least one variable part and at least one fixed part, assigning each log entry of the plurality of log entries to one respective template based on the generated at least one template using a similarity measure, extracting the corresponding at least one variable and at least one fixed part of each text message of the plurality of text messages as key/value pairs using the respective assigned at least one template based on the plurality of log entries, and providing the text messages, keys and values as triples.Type: ApplicationFiled: December 10, 2020Publication date: January 5, 2023Inventors: Georgia Olympia Brikis, Dmitry Fradkin, Vladimir Lavrik, Serghei Mogoreanu, André Scholz
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Patent number: 11499922Abstract: An inspection system for a drug container is provided to identify foreign matter, such as particles or fibers, within the drug container prior to filling with a drug. The system includes a camera device aligned with an axis of the drug container and captures a series of images of an interior surface of a sidewall of the drug container while the robot causes relative movement between the drug container and the camera device along a linear path. Atypical lighting, which improves contrast between particles and the background in images is employed to aid detection. A control circuit then processes the series of images to identify foreign matter within the drug container.Type: GrantFiled: February 12, 2019Date of Patent: November 15, 2022Assignee: AMGEN INC.Inventors: Thomas C. Pearson, Neelima Chavali, Dmitry Fradkin, Graham F. Milne, Erwin Freund
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Publication number: 20220230394Abstract: A method for 3D imaging of a sample, in a vessel having a longitudinal axis orthogonal to a horizontal plane, includes capturing, by at least three cameras located at different positions around the vessel, respective 2D images of the sample. Each image comprises pixels having associated pixel values. The optical axis of a first camera is inclined or declined at a first angle relative to the horizontal plane, with the first angle being greater than or equal to zero degrees. The optical axis of a second camera is inclined or declined at a second, larger angle relative to the horizontal plane. The method also includes generating a 3D image of the sample based on the pixel values associated with the 2D image pixels, and one or more look-up tables that collectively indicate, for pixels in each image, expected paths for light traversing the vessel and the sample.Type: ApplicationFiled: June 2, 2020Publication date: July 21, 2022Inventors: Graham F. Milne, Dmitry Fradkin, Thomas Clark Pearson
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Publication number: 20220057336Abstract: In a method for imaging a container holding a sample, the container is illuminated with a laser sheet that impinges upon the container in a first direction corresponding to a first axis. A plane of the laser sheet is defined by the first axis and a second axis orthogonal to the first axis. The method also includes capturing, by a camera having an imaging axis that is substantially orthogonal to at least the first axis, an image of the container. The method further includes analyzing, by one or more processors, the image of the container to detect particles within, and/or on an exterior surface of, the container.Type: ApplicationFiled: December 16, 2019Publication date: February 24, 2022Inventors: Thomas Clark Pearson, Graham F. Milne, Dmitry Fradkin, Erwin Freund
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Publication number: 20210213486Abstract: A robotic inspection platform comprises a robotic arm, an imager, and a controller. The controller causes the robotic arm to retrieve, using its end effector, a container, and to manipulate the container such that the container is sequentially placed in a plurality of orientations while in view of the imager. The controller also causes the imager to capture images, with each of the images being captured while the container is in a respective one of the orientations. The controller also determines one or more attributes of the container, and/or a sample within the container, by analyzing the images using a pattern recognition model and, based on the attribute(s), determines whether the container and/or sample satisfies one or more criteria. If the container and/or sample fails to satisfy the criteria, the controller causes the robotic arm to place the container in an area (e.g., bin) reserved for rejected containers and/or samples.Type: ApplicationFiled: June 12, 2019Publication date: July 15, 2021Inventors: Dmitry Fradkin, Thomas C. Pearson, Neelima Chavali, Erwin Freund
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Patent number: 10962756Abstract: A system is described to facilitate the characterization of particles within a fluid contained in a vessel using an illumination system that directs source light through each vessel. One or more optical elements may be implemented to refract the source light and to illuminate the entire volume of the vessel. As the refracted source light passes through the vessel and interacts with particles suspended in the fluid, scattered light is produced and directed to an imager, while the refracted source light is diverted away from the imager to prevent the source light from drowning out the scattered light. The system can therefore advantageously utilize an imager with a large depth of field to accurately image the entire volume of fluid at the same time, facilitating the determination of the number and size of particles suspended in the fluid.Type: GrantFiled: December 10, 2019Date of Patent: March 30, 2021Assignee: AMGEN INC.Inventors: Dmitry Fradkin, Graham F. Milne, Thomas Clark Pearson
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Publication number: 20210010946Abstract: An inspection system for a drug container is provided to identify foreign matter, such as particles or fibers, within the drug container prior to filling with a drug. The system includes a camera device aligned with an axis of the drug container and captures a series of images of an interior surface of a sidewall of the drug container while the robot causes relative movement between the drug container and the camera device along a linear path. Atypical lighting, which improves contrast between particles and the background in images is employed to aid detection. A control circuit then processes the series of images to identify foreign matter within the drug container.Type: ApplicationFiled: February 12, 2019Publication date: January 14, 2021Inventors: Thomas C. Pearson, Neelima Chavali, Dmitry Fradkin, Graham F. Milne, Erwin Freund
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Publication number: 20200142172Abstract: A system is described to facilitate the characterization of particles within a fluid contained in a vessel using an illumination system that directs source light through each vessel. One or more optical elements may be implemented to refract the source light and to illuminate the entire volume of the vessel. As the refracted source light passes through the vessel and interacts with particles suspended in the fluid, scattered light is produced and directed to an imager, while the refracted source light is diverted away from the imager to prevent the source light from drowning out the scattered light. The system can therefore advantageously utilize an imager with a large depth of field to accurately image the entire volume of fluid at the same time, facilitating the determination of the number and size of particles suspended in the fluid.Type: ApplicationFiled: December 10, 2019Publication date: May 7, 2020Inventors: Dmitry Fradkin, Graham F. Milne, Thomas Clark Pearson
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Patent number: 10539773Abstract: A system is described to facilitate the characterization of particles within a fluid contained in a vessel using an illumination system that directs source light through each vessel. One or more optical elements may be implemented to refract the source light and to illuminate the entire volume of the vessel. As the refracted source light passes through the vessel and interacts with particles suspended in the fluid, scattered light is produced and directed to an imager, while the refracted source light is diverted away from the imager to prevent the source light from drowning out the scattered light. The system can therefore advantageously utilize an imager with a large depth of field to accurately image the entire volume of fluid at the same time, facilitating the determination of the number and size of particles suspended in the fluid.Type: GrantFiled: August 27, 2018Date of Patent: January 21, 2020Assignee: AMGEN INC.Inventors: Dmitry Fradkin, Graham F. Milne, Thomas Clark Pearson
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Publication number: 20190011688Abstract: A system is described to facilitate the characterization of particles within a fluid contained in a vessel using an illumination system that directs source light through each vessel. One or more optical elements may be implemented to refract the source light and to illuminate the entire volume of the vessel. As the refracted source light passes through the vessel and interacts with particles suspended in the fluid, scattered light is produced and directed to an imager, while the refracted source light is diverted away from the imager to prevent the source light from drowning out the scattered light. The system can therefore advantageously utilize an imager with a large depth of field to accurately image the entire volume of fluid at the same time, facilitating the determination of the number and size of particles suspended in the fluid.Type: ApplicationFiled: August 27, 2018Publication date: January 10, 2019Inventors: Dmitry Fradkin, Graham F. Milne, Thomas Clark Pearson
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Patent number: 10088660Abstract: A system is described to facilitate the characterization of particles within a fluid contained in a vessel using an illumination system that directs source light through each vessel. One or more optical elements may be implemented to refract the source light and to illuminate the entire volume of the vessel. As the refracted source light passes through the vessel and interacts with particles suspended in the fluid, scattered light is produced and directed to an imager, while the refracted source light is diverted away from the imager to prevent the source light from drowning out the scattered light. The system can therefore advantageously utilize an imager with a large depth of field to accurately image the entire volume of fluid at the same time, facilitating the determination of the number and size of particles suspended in the fluid.Type: GrantFiled: February 10, 2017Date of Patent: October 2, 2018Assignee: AMGEN INC.Inventors: Dmitry Fradkin, Graham F. Milne, Thomas Clark Pearson
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Publication number: 20180231760Abstract: A system is described to facilitate the characterization of particles within a fluid contained in a vessel using an illumination system that directs source light through each vessel. One or more optical elements may be implemented to refract the source light and to illuminate the entire volume of the vessel. As the refracted source light passes through the vessel and interacts with particles suspended in the fluid, scattered light is produced and directed to an imager, while the refracted source light is diverted away from the imager to prevent the source light from drowning out the scattered light. The system can therefore advantageously utilize an imager with a large depth of field to accurately image the entire volume of fluid at the same time, facilitating the determination of the number and size of particles suspended in the fluid.Type: ApplicationFiled: February 10, 2017Publication date: August 16, 2018Inventors: Dmitry Fradkin, Graham F. Milne, Thomas Clark Pearson