Abstract: The present invention provides methods for making and using antibacterial polymeric materials loaded with additives, as well as antibacterial materials comprising additives. Certain additives or combinations of additives show unexpected combinatorial or synergistic antibacterial activity. The invention also provides medical devices comprised of antibacterial polymeric materials, and methods of making and using such devices, which can have unexpected combinatorial or synergistic antibacterial activity.

Abstract: Provided is an orthopedic implant comprising a surface with a coating on the surface wherein the coating comprises a copolymer defined by Formula I: Aw-Bx-Cy-Dz wherein: A comprises an epoxy group; B comprises a hydrophobic group; C is an optional cross-linker; D of Formula I comprises a hydrophilic group; w is at least 0.1 to no more than 0.9 with the proviso that at least one of x or z is not zero; x is up to 0.9; y is up to 0.3; and z is up to 0.9.