Patents by Inventor Dmitry KLOKOV

Dmitry KLOKOV has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method to Improve Therapeutic Properties of Stem Cells
    Publication number: 20240024373
    Abstract: In one aspect, a method of preconditioning stem cells comprising exposing stem cells to low dose radiation (LDR) is provided. In another aspect, a population of preconditioned stem cells is provided, wherein the population of 5 preconditioned stem cells is obtained by exposing stem cells to LDR. Uses of the preconditioned stem cells are also provided. In other aspects, the stem cells are muscle stem cells.
    Type: Application
    Filed: July 14, 2023
    Publication date: January 25, 2024
    Inventors: Dmitry KLOKOV, Soji SEBASTIAN, Yevgeniya LE
  • Method to improve therapeutic properties of stem cells
    Patent number: 11738054
    Abstract: In one aspect, a method of preconditioning stem cells comprising exposing stem cells to low dose radiation (LDR) is provided. In another aspect, a population of preconditioned stem cells is provided, wherein the population of 5 preconditioned stem cells is obtained by exposing stem cells to LDR. Uses of the preconditioned stem cells are also provided. In other aspects, the stem cells are muscle stem cells.
    Type: Grant
    Filed: July 20, 2018
    Date of Patent: August 29, 2023
    Assignee: ATOMIC ENERGY OF CANADA LIMITED/ENERGIE ATOMIQUE DU CANADA LIMITÈE
    Inventors: Dmitry Klokov, Soji Sebastian, Yevgeniya Le
  • USE OF A CHECKPOINT INHIBITOR IN COMBINATION WITH ULTRALOW DOSE WHOLE BODY IRRADIATION
    Publication number: 20210221889
    Abstract: The present invention relates to a method to improve the anti-tumour effects of immune checkpoint therapy by combining the use of a checkpoint inhibitor with ultralow dose whole body irradiation. The present invention enhances the anti-tumour effects of immune checkpoint therapy by reducing tumour volume as well as shortening the response time of the immune checkpoint therapy, as compared to immune checkpoint therapy on its own.
    Type: Application
    Filed: June 7, 2019
    Publication date: July 22, 2021
    Inventors: Yi WANG, Michelle BUGDEN, Laura BANNISTER, Dmitry KLOKOV
  • METHOD TO IMPROVE THERAPEUTIC PROPERTIES OF STEM CELLS
    Publication number: 20200230180
    Abstract: In one aspect, a method of preconditioning stem cells comprising exposing stem cells to low dose radiation (LDR) is provided. In another aspect, a population of preconditioned stem cells is provided, wherein the population of 5 preconditioned stem cells is obtained by exposing stem cells to LDR. Uses of the preconditioned stem cells are also provided. In other aspects, the stem cells are muscle stem cells.
    Type: Application
    Filed: July 20, 2018
    Publication date: July 23, 2020
    Inventors: Dmitry KLOKOV, Soji SEBASTIAN, Yevgeniya LE