Patents by Inventor Dmitry MAZUNIN
Dmitry MAZUNIN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240400556Abstract: The present invention provides compounds of formula I or II: wherein X1, X3, R1, R2, R3, R4 and R5 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula I, pharmaceutical compositions comprising them and their use as medicaments.Type: ApplicationFiled: May 3, 2024Publication date: December 5, 2024Applicant: Hoffmann-La Roche Inc.Inventors: Andrew Simon Bell, Jérémy Besnard, Anthony Richard Bradley, Luke Green, Wolfgang Haap, Buelent Kocer, Andreas Kuglstatter, Xavier Lucas, Patrizio Mattei, Dmitry Mazunin, Hasane Ratni, Claus Riemer, Willem Paul Van Hoorn
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Publication number: 20240025883Abstract: Compounds having the general formula I wherein R1, R2, R3, R4, X1 and X2 are as described herein, composition including the compounds and methods of using the compounds for treatment of GPR17-mediated diseases.Type: ApplicationFiled: August 24, 2023Publication date: January 25, 2024Applicant: Hoffmann-La Roche Inc.Inventors: Guido GALLEY, Luca GOBBI, Wolfgang GUBA, Dmitry MAZUNIN, Emmanuel PINARD, Antonio RICCI
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Publication number: 20230382911Abstract: The present invention provides compounds of formula I or II: wherein X1, R1 and R2 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula I, pharmaceutical compositions comprising them and their use as medicaments.Type: ApplicationFiled: July 28, 2023Publication date: November 30, 2023Applicant: Hoffmann-La Roche Inc.Inventors: Andrew Simon BELL, Jérémy BESNARD, Anthony Richard BRADLEY, Luke GREEN, Wolfgang HAAP, Buelent KOCER, Andreas KUGLSTATTER, Xavier LUCAS, Patrizio MATTEI, Dmitry MAZUNIN, Claus RIEMER, Willem Paul VAN HOORN
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Publication number: 20230227449Abstract: The present invention provides compounds of formula I or II: wherein X1, X3, R1, R2, R3, R4 and R5 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula I, pharmaceutical compositions comprising them and their use as medicaments.Type: ApplicationFiled: December 19, 2022Publication date: July 20, 2023Applicant: Hoffmann-La Roche Inc.Inventors: Andrew Simon Bell, Jérémy Besnard, Anthony Richard Bradley, Luke Green, Wolfgang Haap, Buelent Kocer, Andreas Kuglstatter, Xavier Lucas, Patrizio Mattei, Dmitry Mazunin, Hasane Ratni, Claus Riemer, Willem Paul Van Hoorn
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Publication number: 20230219953Abstract: The present invention provides compounds of formula I wherein X1, X2, X3, X4, R1, R1a, R1b, R2?, R2?, R3?, R3?, R6 and R7 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula I, pharmaceutical compositions comprising them and their use as medicaments.Type: ApplicationFiled: December 19, 2022Publication date: July 13, 2023Applicant: Hoffmann-La Roche Inc.Inventors: Andrew Simon Bell, Jérémy Besnard, Anthony Richard Bradley, Luke Green, Wolfgang Haap, Buelent Kocer, Andreas Kuglstatter, Xavier Lucas, Patrizio Mattei, Dmitry Mazunin, Claus Riemer, Willem Paul Van Hoorn
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Publication number: 20230174516Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4 and R5 are as defined herein, compositions including the compounds and methods of using the compounds.Type: ApplicationFiled: December 7, 2022Publication date: June 8, 2023Applicant: Hoffmann-La Roche Inc.Inventors: Angelica BEURIER, Michail Konstantinos BOGDOS, Luke GREEN, Christian KRAMER, Dmitry MAZUNIN, Emmanuel PINARD, Hasane RATNI
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Publication number: 20230123268Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3 and n are as defined herein, compositions including methods of making the compounds and using the compounds as ATX inhibitors.Type: ApplicationFiled: December 7, 2022Publication date: April 20, 2023Applicant: Hoffmann-La Roche Inc.Inventors: Angélica BEURIER, Luke GREEN, Christian KRAMER, Dmitry MAZUNIN, Emmanuel PINARD, Hasane RATNI
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Publication number: 20230112172Abstract: The invention provides novel compounds having the general formula I wherein R1, R2, and R3 are as defined herein, compositions including the compounds and methods of using the compounds.Type: ApplicationFiled: December 7, 2022Publication date: April 13, 2023Applicant: Hoffmann-La Roche Inc.Inventors: Virginie BROM, Luke GREEN, Christian KRAMER, Dmitry MAZUNIN, Emmanuel PINARD, Hasane RATNI
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Patent number: 9944750Abstract: Polyethylene glycol substituted acyl borates, methods for their preparation, and the use of the polyethylene glycol substituted acyl borates for the preparation of polyethylene glycol substituted macromolecules. The polyethylene glycol substituted acyl borate has the general formula (I) wherein PEG denotes a polyethylene glycol-based substituent; a is an integer from 1 to 12; X1, X2, and X3 are independently of one another selected from the group made of F, OR, N+R3, N+R2OR, N+R2SR, and N+R2NR2, and are optionally forming a cyclic or a bicyclic structure; and R is an organic substituent or H.Type: GrantFiled: January 9, 2015Date of Patent: April 17, 2018Assignee: ETH ZURICHInventors: Jeffrey Bode, Hidetoshi Noda, Gabor Eros, Dmitry Mazunin
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Publication number: 20170022321Abstract: Polyethylene glycol substituted acyl borates, methods for their preparation, and the use of the polyethylene glycol substituted acyl borates for the preparation of polyethylene glycol substituted macromolecules. The polyethylene glycol substituted acyl borate has the general formula (I) wherein PEG denotes a polyethylene glycol-based substituent; a is an integer from 1 to 12; X1, X2, and X3 are independently of one another selected from the group made of F, OR, N+R3, N+R2OR, N+R2SR, and N+R2NR2, and are optionally forming a cyclic or a bicyclic structure; and R is an organic substituent or H.Type: ApplicationFiled: January 9, 2015Publication date: January 26, 2017Applicant: ETH ZurichInventors: Jeffrey BODE, Hidetoshi NODA, Gabor EROS, Dmitry MAZUNIN