Patents by Inventor Dmitry Pruss

Dmitry Pruss has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240282407
    Abstract: A computer-implemented method is discussed that includes identifying, by a computer server system, stored electronic data that represents genetic sequencing for one or more genes for individuals in a population of patients who have submitted to genetic sequencing; generating, for each of multiple individuals and from the stored electronic data, probability data for the individuals and probability or weighting data, or both, for relatives of the individuals, the probability data representing likelihoods that a particular person corresponding to the probability data carries a deleterious mutation in a particular gene; and generating a score for a genetic variant, wherein the score is a function of probability or weighting data, or both, for the individuals and for relatives of the individuals, and the score represent a composite probability that a certain variant is a deleterious or benign variant.
    Type: Application
    Filed: April 25, 2024
    Publication date: August 22, 2024
    Applicant: Myriad Genetics, Inc.
    Inventors: Dmitry Pruss, Brian Morris, Karla Bowles, Julie M. Eggington, Benjamin B. Roa, Alexander Gutin, Elisha Hughes
  • Publication number: 20230260658
    Abstract: Provided herein are methods for determining polygenic traits and risks for medical use, such as cancer traits and risks, as well as treating diseases for which risk is identified and/or assessed. Methods of this invention can provide a polygenic score which takes into account local ancestry through the ancestral origin of the alleles of risk loci. A polygenic score can provide surprisingly increased accuracy in determining polygenic traits and risks for ancestrally admixed populations.
    Type: Application
    Filed: April 16, 2021
    Publication date: August 17, 2023
    Applicant: Myriad Genetics, Inc.
    Inventors: Dmitry Pruss, Alexander Gutin, Elisha Hughes, Jerry Lanchbury
  • Publication number: 20140278135
    Abstract: A computer-implemented method is discussed that includes identifying, by a computer server system, stored electronic data that represents genetic sequencing for one or more genes for individuals in a population of patients who have submitted to genetic sequencing; generating, for each of multiple individuals and from the stored electronic data, probability data for the individuals and probability or weighting data, or both, for relatives of the individuals, the probability data representing likelihoods that a particular person corresponding to the probability data carries a deleterious mutation in a particular gene; and generating a score for a genetic variant, wherein the score is a function of probability or weighting data, or both, for the individuals and for relatives of the individuals, and the score represent a composite probability that a certain variant is a deleterious or benign variant.
    Type: Application
    Filed: March 13, 2014
    Publication date: September 18, 2014
    Applicant: Myriad Genetics, Inc.
    Inventors: Dmitry Pruss, Brian Morris, Karla Bowles, Julie M. Eggington, Benjamin B. Roa, Alexander Gutin, Elisha Hughes
  • Publication number: 20080318223
    Abstract: Large deletions have been identified in the BRCA1 gene in patients. The large deletions predispose the patients to breast cancer and ovarian cancer. Thus, methods for detecting the genetic variants are provided which can be used in detecting a predisposition to cancer.
    Type: Application
    Filed: July 30, 2007
    Publication date: December 25, 2008
    Applicant: Myriad Genetics, Incorporated
    Inventors: Thomas Scholl, Brant C. Hendrickson, Benjamin Ward, Dmitry Pruss
  • Publication number: 20080318224
    Abstract: Large deletions have been identified in the BRCA1 gene in patients. The large deletions predispose the patients to breast cancer and ovarian cancer. Thus, methods for detecting the genetic variants are provided which can be used in detecting a predisposition to cancer.
    Type: Application
    Filed: July 30, 2007
    Publication date: December 25, 2008
    Applicant: Myriad Genetics, Incorporated
    Inventors: Thomas Scholl, Brant C. Hendrickson, Benjamin Ward, Dmitry Pruss
  • Patent number: 7250497
    Abstract: Large deletions have been identified in the BRCA1 gene in patients. The large deletions predispose the patients to breast cancer and ovarian cancer. Thus, methods for detecting the genetic variants are provided which can be used in detecting a predisposition to cancer.
    Type: Grant
    Filed: June 9, 2003
    Date of Patent: July 31, 2007
    Assignee: Myriad Genetics, Inc.
    Inventors: Thomas Scholl, Brant C. Hendrickson, Benjamin Ward, Dmitry Pruss
  • Patent number: 6895337
    Abstract: Methods, computer program products and systems are provided for detecting large genomic rearrangements based on unphased genotype data obtained using common genotyping techniques that do not differentiate different alleles. In the method, unphased genotypes at a plurality of nucleotide variant markers of a particular gene in a diploid subject are compared with a canonical haplotype collection of the gene for a heterogeneous subject population. If the unphased genotypes cannot be reduced to a pair of canonical haplotypes within the canonical haplotype collection, it would indicate an increased likelihood that an allele of the gene in the diploid subject harbors a genomic rearrangement.
    Type: Grant
    Filed: October 15, 2002
    Date of Patent: May 17, 2005
    Assignee: Myriad Genetics, Inc.
    Inventors: Thomas Scholl, Dmitry Pruss, Brant C. Hendrickson
  • Patent number: 6835537
    Abstract: A method for normalizing the intensity of G bands in sequencing methods which utilize dITP is presented. The use of dITP normally results in decreased intensities of G bands which occur after A bands, i.e., in the sequence AG. It has been discovered that the use of ddITP in place of ddGTP or in conjunction with ddGTP helps to normalize the intensity of the G bands following A bands. This aids in preventing errors in reading sequencing chromatograms and allows for extended reads of sequencing chromatograms as compared to methods which utilize dITP without the use of ddITP.
    Type: Grant
    Filed: November 27, 2000
    Date of Patent: December 28, 2004
    Assignee: Myriad Genetics, Inc.
    Inventors: Nadeem Tusneem, Dmitry Pruss, Min-Jui Richard Shen, Satish K. Bhatnagar
  • Publication number: 20040014115
    Abstract: Large deletions have been identified in the BRCA1 gene in patients. The large deletions predispose the patients to breast cancer and ovarian cancer. Thus, methods for detecting the genetic variants are provided which can be used in detecting a predisposition to cancer.
    Type: Application
    Filed: June 9, 2003
    Publication date: January 22, 2004
    Applicant: Myriad Genetics, Incorporated
    Inventors: Thomas Scholl, Brant C. Hendrickson, Benjamin Ward, Dmitry Pruss