Patents by Inventor Dmitry V. Filippov

Dmitry V. Filippov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peptide-containing adjuvant compounds having peg spacers
    Patent number: 12016918
    Abstract: Adjuvant compounds are described, as well as their conjugates comprising peptide antigens or other immunomodulatory moieties. Also described are methods of modulating immune responses in a subject in need thereof, as well as methods of treating cancer, viral or bacterial infections comprising administering the adjuvant compounds or the conjugates to a subject in need thereof.
    Type: Grant
    Filed: April 25, 2018
    Date of Patent: June 25, 2024
    Assignees: UNIVERSITEIT LEIDEN, ACADEMISCH ZIEKENHUIS LEIDEN
    Inventors: Dmitri V. Filippov, Geoffroy P. P. Gential, Gijsbert Van Der Marel, Ferry Ossendorp
  • ADJUVANT COMPOUNDS
    Publication number: 20200188512
    Abstract: Adjuvant compounds are described, as well as their conjugates comprising peptide antigens or other immunomodulatory moieties. Also described are methods of modulating immune responses in a subject in need thereof, as well as methods of treating cancer, viral or bacterial infections comprising administering the adjuvant compounds or the conjugates to a subject in need thereof.
    Type: Application
    Filed: April 25, 2018
    Publication date: June 18, 2020
    Inventors: Dmitri V. FILIPPOV, Geoffroy P. P. GENTIAL, Gijsbert VAN DER MAREL, Ferry OSSENDORP
  • Inhibitors of the trypsin-like site of the proteasome and methods of use thereof
    Patent number: 8609610
    Abstract: The present invention is an inhibitor of the trypsin-like ?2/?2i sites of the proteasome. The inhibitor is characterized as being a peptide-based epoxyketone or vinyl sulfone that contains an arginine or 4-aminomethylene-L-phenylalanine at the C-terminus (i.e., at the P1 position). Methods for using the inhibitor to inhibit the activity of the ?2/?2i site of a proteasome and treat a proteasome-mediated disease or condition are also described.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: December 17, 2013
    Assignees: Trustees of Dartmouth College, Leiden University
    Inventors: Alexei Kisselev, Dmitry V. Filippov, Herman Overkleeft
  • Inhibitors of the trypsin-like site of the proteasome and methods of use thereof
    Patent number: 8455431
    Abstract: The present invention is an inhibitor of the trypsin-like ?2/?2i sites of the proteasome. The inhibitor is characterized as being a peptide-based epoxyketone or vinyl sulfone that contains an arginine or 4-aminomethylene-L-phenylalanine at the C-terminus (i.e., at the P1 position). Methods for using the inhibitor to inhibit the activity of the ?2/?2i site of a proteasome and treat a proteasome-mediated disease or condition are also described.
    Type: Grant
    Filed: February 17, 2012
    Date of Patent: June 4, 2013
    Assignees: Trustees of Dartmout College, Leiden University
    Inventors: Alexei Kisselev, Dmitry V. Filippov, Herman Overkleeft
  • Inhibitors of the Trypsin-Like Site of the Proteasome and Methods of Use Thereof
    Publication number: 20120214732
    Abstract: The present invention is an inhibitor of the trypsin-like ?2/?2i sites of the proteasome. The inhibitor is characterized as being a peptide-based epoxyketone or vinyl sulfone that contains an arginine or 4-aminomethylene-L-phenylalanine at the C-terminus (i.e., at the P1 position). Methods for using the inhibitor to inhibit the activity of the ?2/?2i site of a proteasome and treat a proteasome-mediated disease or condition are also described.
    Type: Application
    Filed: February 17, 2012
    Publication date: August 23, 2012
    Applicant: Trustees of Dartmouth College
    Inventors: Alexei Kisselev, Dmitry V. Filippov, Herman Overkleeft