Patents by Inventor Dmitry Vladimirovich Dylov
Dmitry Vladimirovich Dylov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220346856Abstract: Disclosed are various embodiments of methods, components and systems configured to determine a location of a source of cardiac arrhythmia in a patient's heart. In some embodiments, to determine a source location, electrogram signals are acquired from a region of the patients' heart using a first set of electrodes; and then a pre-trained artificial intelligence (AI) model is applied to predict the location of the cardiac arrhythmia source by using the signals. Importantly, pre-training of the AI model comprises acquiring electrogram signals from explanted human hearts, the signals are generated by a second set of electrodes assembled into an electrode array that covers at least a part of the explanted human heart, and acquiring co-registered functional and/or structural imaging data in the part of the explanted human heart covered with the electrode array, wherein the functional and/or structural imaging data provide location of at least one source of cardiac arrhythmia.Type: ApplicationFiled: May 6, 2020Publication date: November 3, 2022Inventors: Vadim Valerievich FEDOROV, Brian HANSEN, Alexander Markovich ZOLOTAREV, Dmitry Vladimirovich DYLOV, Ekaterina Alekseevna IVANOVA, Maxim Valerievich FEDOROV
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Patent number: 10531862Abstract: A biopsy collecting device includes a needle unit comprising a biopsy specimen. Also, the biopsy collecting device includes an activator unit operatively coupled to the needle unit and including a channel at a bottom surface of the activator unit, wherein the channel is configured to detachably couple the biopsy collecting device to an attaching unit of a spectroscopy system.Type: GrantFiled: March 13, 2015Date of Patent: January 14, 2020Assignee: GENERAL ELECTRIC COMPANYInventors: Siavash Yazdanfar, Victor Petrovich Ostroverkhov, Dmitry Vladimirovich Dylov, Stephen B. Solomon, Jeremy C. Durack
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Patent number: 10423820Abstract: The subject matter of the present disclosure generally relates to techniques for image analysis. In certain embodiments, various morphological or intensity-based features as well as different thresholding approaches may be used to segment the subpopulation of interest and classify object in the images.Type: GrantFiled: September 13, 2017Date of Patent: September 24, 2019Assignee: GENERAL ELECTRIC COMPANYInventors: Alberto Santamaria-Pang, Qing Li, Yunxia Sui, Dmitry Vladimirovich Dylov, Christopher James Sevinsky, Michael E. Marino, Michael J. Gerdes, Daniel Eugene Meyer, Fiona Ginty, Anup Sood
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Publication number: 20190080146Abstract: The subject matter of the present disclosure generally relates to techniques for image analysis. In certain embodiments, various morphological or intensity-based features as well as different thresholding approaches may be used to segment the subpopulation of interest and classify object in the images.Type: ApplicationFiled: September 13, 2017Publication date: March 14, 2019Inventors: Alberto Santamaria-Pang, Qing Li, Yunxia Sui, Dmitry Vladimirovich Dylov, Christopher James Sevinsky, Michael E. Marino, Michael J. Gerdes, Daniel Eugene Meyer, Fiona Ginty, Anup Sood
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Patent number: 9913628Abstract: A method for classifying a tissue sample of a biopsy specimen includes receiving a signal from at least one location of the tissue sample including a plurality of chromophores. Further, the method includes verifying whether the received signal comprises a predetermined amount of at least one of an attenuated illumination light and a re-emitted light. Also, the method includes determining that a spectrum of the received signal is within a predetermined range. In addition, the method includes processing the spectrum of the received signal to decompose the signal into a plurality of components. Furthermore, the method includes classifying tissue in the at least one location of the tissue sample into one of a plurality of tissue types based on the plurality of components.Type: GrantFiled: March 13, 2015Date of Patent: March 13, 2018Assignee: GENERAL ELECTRIC COMPANYInventors: Siavash Yazdanfar, Victor Petrovich Ostroverkhov, Dmitry Vladimirovich Dylov, Stephen B. Solomon, Jeremy C. Durack
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Patent number: 9216010Abstract: A spectroscopy system for auto-aligning a biopsy collecting device is presented. The spectroscopy system includes an illumination subsystem configured to emit an illumination light towards the biopsy collecting device, whereas the biopsy collecting device includes an activator unit and a needle unit and wherein the needle unit includes a cannula and a stylet having a biopsy specimen. Also, the spectroscopy system includes a fixation subsystem capable of holding the biopsy collecting device and configured to place the needle unit comprising the biopsy specimen across the illumination light. Further, the spectroscopy system includes a detection subsystem configured to receive a light comprising at least one of an attenuated illumination light and a re-emitted light from the needle unit. In addition, the detection subsystem is configured to send a control signal to align the needle unit at a predetermined position in the spectroscopy system based on the received light.Type: GrantFiled: June 26, 2013Date of Patent: December 22, 2015Assignee: General Electric CompanyInventors: Victor Petrovich Ostroverkhov, Dmitry Vladimirovich Dylov, Siavash Yazdanfar, Stephen B. Solomon
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Publication number: 20150182204Abstract: A biopsy collecting device includes a needle unit comprising a biopsy specimen. Also, the biopsy collecting device includes an activator unit operatively coupled to the needle unit and including a channel at a bottom surface of the activator unit, wherein the channel is configured to detachably couple the biopsy collecting device to an attaching unit of a spectroscopy system.Type: ApplicationFiled: March 13, 2015Publication date: July 2, 2015Inventors: Siavash Yazdanfar, Victor Petrovich Ostroverkhov, Dmitry Vladimirovich Dylov, Stephen B. Solomon, Jeremy C. Durack
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Publication number: 20150185140Abstract: A method for classifying a tissue sample of a biopsy specimen includes receiving a signal from at least one location of the tissue sample including a plurality of chromophores. Further, the method includes verifying whether the received signal comprises a predetermined amount of at least one of an attenuated illumination light and a re-emitted light. Also, the method includes determining that a spectrum of the received signal is within a predetermined range. In addition, the method includes processing the spectrum of the received signal to decompose the signal into a plurality of components. Furthermore, the method includes classifying tissue in the at least one location of the tissue sample into one of a plurality of tissue types based on the plurality of components.Type: ApplicationFiled: March 13, 2015Publication date: July 2, 2015Inventors: Siavash Yazdanfar, Victor Petrovich Ostroverkhov, Dmitry Vladimirovich Dylov, Stephen B. Solomon, Jeremy C. Durack
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Patent number: 8934103Abstract: Systems and methods described herein employ multiple phase-contrast images with various relative phase shifts between light diffracted by a sample and light not diffracted by the sample to produce a quantitative phase image. The produced quantitative phase image may have sufficient contrast for label-free auto-segmentation of cell bodies and nuclei.Type: GrantFiled: October 29, 2012Date of Patent: January 13, 2015Assignee: General Electric CompanyInventors: Evgenia Mikhailovna Kim, Siavash Yazdanfar, Dmitry Vladimirovich Dylov
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Publication number: 20150001420Abstract: A method for classifying a tissue sample of a biopsy specimen into one of a plurality of classes is presented. The method includes receiving a light from at least one location of the tissue sample including a plurality of chromophores, wherein the received light comprises at least one of an attenuated illumination light and a re-emitted light. The method further includes processing a spectrum of the received light to determine a feature for each of the chromophores in the at least one location of the tissue sample. In addition, the method includes estimating a Z-score for each of the chromophores based on the determined feature. Also, the method includes classifying the tissue sample into one of the plurality of classes based on the estimated Z-score for each of the chromophores.Type: ApplicationFiled: June 26, 2013Publication date: January 1, 2015Inventors: Rajesh Veera Venkata Lakshmi Langoju, Abhijit Vishwas Patil, Sridhar Dasaratha, Vignesh Thirukazhukundram Subrahmaniam, Dmitry Vladimirovich Dylov, Siavash Yazdanfar, Stephen B. Solomon
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Publication number: 20150002845Abstract: A spectroscopy system for auto-aligning a biopsy collecting device is presented. The spectroscopy system includes an illumination subsystem configured to emit an illumination light towards the biopsy collecting device, whereas the biopsy collecting device includes an activator unit and a needle unit and wherein the needle unit includes a cannula and a stylet having a biopsy specimen. Also, the spectroscopy system includes a fixation subsystem capable of holding the biopsy collecting device and configured to place the needle unit comprising the biopsy specimen across the illumination light. Further, the spectroscopy system includes a detection subsystem configured to receive a light comprising at least one of an attenuated illumination light and a re-emitted light from the needle unit. In addition, the detection subsystem is configured to send a control signal to align the needle unit at a predetermined position in the spectroscopy system based on the received light.Type: ApplicationFiled: June 26, 2013Publication date: January 1, 2015Inventors: Victor Petrovich Ostroverkhov, Dmitry Vladimirovich Dylov, Siavash Yazdanfar, Stephen B. Solomon
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Publication number: 20150004641Abstract: An apparatus for holding a biopsy collecting device is presented. The apparatus includes a base unit configured to receive the biopsy collecting device comprising at least a needle unit and an activator unit, wherein the needle unit comprises a biopsy specimen. The apparatus further includes a fastening unit disposed at a first end of the base unit and configured to fasten at least a first portion of the needle unit to the base unit. Also, the apparatus includes a holding unit disposed at a second end of the base unit and configured to attach the activator unit of the biopsy collecting device to the base unit.Type: ApplicationFiled: June 26, 2013Publication date: January 1, 2015Inventors: Dmitry Vladimirovich Dylov, Juan Pablo Cilia, Victor Petrovich Ostroverkhov, Siavash Yazdanfar, Stephen B. Solomon
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Patent number: 8912512Abstract: A method for classifying a tissue sample of a biopsy specimen into one of a plurality of classes is presented. The method includes receiving a light from at least one location of the tissue sample including a plurality of chromophores, wherein the received light comprises at least one of an attenuated illumination light and a re-emitted light. The method further includes processing a spectrum of the received light to determine a feature for each of the chromophores in the at least one location of the tissue sample. In addition, the method includes estimating a Z-score for each of the chromophores based on the determined feature. Also, the method includes classifying the tissue sample into one of the plurality of classes based on the estimated Z-score for each of the chromophores.Type: GrantFiled: June 26, 2013Date of Patent: December 16, 2014Assignee: General Electric CompanyInventors: Rajesh Veera Venkata Lakshmi Langoju, Abhijit Vishwas Patil, Sridhar Dasaratha, Vignesh Thirukazhukundram Subrahmaniam, Dmitry Vladimirovich Dylov, Siavash Yazdanfar, Stephen B. Solomon
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Patent number: 8778682Abstract: A method of delivering exogenous molecules, comprising: providing a plurality of cells having a cell membrane; adding a plurality of exogenous molecules to the cells; exposing the cells to a defocused infrared (IR) light to permeabilize the cell membrane of the cells; and delivering the exogenous molecules to the cells through the permeablized cell membrane, wherein an intensity of the IR light at the optical focus is at least greater than or equal to an order of 104 W/cm2.Type: GrantFiled: August 30, 2011Date of Patent: July 15, 2014Assignee: General Electric CompanyInventors: Vasile Bogdan Neculaes, Kenneth Roger Conway, Allen Lawrence Garner, Evelina Roxana Loghin, Siavash Yazdanfar, Dmitry Vladimirovich Dylov, Brian Michael Davis, Chulmin Joo
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Publication number: 20130286400Abstract: Systems and methods described herein employ multiple phase-contrast images with various relative phase shifts between light diffracted by a sample and light not diffracted by the sample to produce a quantitative phase image. The produced quantitative phase image may have sufficient contrast for label-free auto-segmentation of cell bodies and nuclei.Type: ApplicationFiled: October 29, 2012Publication date: October 31, 2013Inventors: Evgenia Mikhailovna Kim, Siavash Yazdanfar, Dmitry Vladimirovich Dylov
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Patent number: 8475975Abstract: In accordance with one aspect of the present invention, a method for recording holographic data in an optical data storage medium is provided. The method includes (i) providing an optical data storage medium including: (a) a thermoplastic polymer matrix, (b) a latent acid generator, (c) a non-linear sensitizer, and (d) a reactant including a latent chromophore. The method further includes (ii) irradiating a volume element of the optical data storage medium with an interference pattern, said interference pattern including an incident radiation having a wavelength and an intensity sufficient to cause upper triplet energy transfer from the non-linear sensitizer to the latent acid generator, thereby generating an acid, wherein the latent acid generator is substantially non-responsive to said incident radiation.Type: GrantFiled: June 21, 2011Date of Patent: July 2, 2013Assignee: General Electric CompanyInventors: Arunkumar Natarajan, Eugene Pauling Boden, Dmitry Vladimirovich Dylov, James Edward Pickett, Evgenia Mikhailovna Kim, Patrick Joseph McCloskey, Kwok Pong Chan, Victor Petrovich Ostroverkhov, Matthew Jeremiah Misner, Vijay Krishna Paruchuru
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Publication number: 20130052725Abstract: A system for delivering exogenous molecules comprises a support for containing cells and exogenous molecules; an infra-red (IR) light source that generates an IR optical beam with an average power density at least greater than 105 W/cm2; one or more optical elements; an imaging system to image the cells in a field of view; a processor that generates a signal for localization of cells in the field of view; a light pattern shaper for temporal focusing of optical beam to generate wide field illumination on the cells to permeabilise the cell membrane for delivering the exogenous molecules; and a controller that switches optical beam from wide field illumination to a focused illumination. The processor is operatively coupled to the imaging system and the light pattern shaper and transmits the signal for the localization of cells to ensure the temporal focusing of the optical beam on the cells.Type: ApplicationFiled: October 31, 2011Publication date: February 28, 2013Applicant: GENERAL ELECTRIC COMPANYInventors: Siavash Yazdanfar, Vasile Bogdan Neculaes, Kenneth Roger Conway, Allen Lawrence Garner, Evelina Roxana Loghin, Dmitry Vladimirovich Dylov, Brian Michael Davis, Chulmin Joo
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Publication number: 20130052738Abstract: A method of delivering exogenous molecules, comprising: providing a plurality of cells having a cell membrane; adding a plurality of exogenous molecules to the cells; exposing the cells to a defocused infrared (IR) light to permeabilize the cell membrane of the cells; and delivering the exogenous molecules to the cells through the permeablized cell membrane, wherein an intensity of the IR light at the optical focus is at least greater than or equal to an order of 104 W/cm2.Type: ApplicationFiled: August 30, 2011Publication date: February 28, 2013Applicant: GENERAL ELECTRIC COMPANYInventors: Vasile Bogdan Neculaes, Kenneth Roger Conway, Allen Lawrence Garner, Evelina Roxana Loghin, Siavash Yazdanfar, Dmitry Vladimirovich Dylov, Brian Michael Davis, Chulmin Joo
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Publication number: 20120328973Abstract: In accordance with one aspect of the present invention, a method for recording holographic data in an optical data storage medium is provided. The method includes (i) providing an optical data storage medium including: (a) a thermoplastic polymer matrix, (b) a latent acid generator, (c) a non-linear sensitizer, and (d) a reactant including a latent chromophore. The method further includes (ii) irradiating a volume element of the optical data storage medium with an interference pattern, said interference pattern including an incident radiation having a wavelength and an intensity sufficient to cause upper triplet energy transfer from the non-linear sensitizer to the latent acid generator, thereby generating an acid, wherein the latent acid generator is substantially non-responsive to said incident radiation.Type: ApplicationFiled: June 21, 2011Publication date: December 27, 2012Applicant: GENERAL ELECTRIC COMPANYInventors: Arunkumar Natarajan, Eugene Pauling Boden, Dmitry Vladimirovich Dylov, James Edward Pickett, Evgenia Mikhailovna Kim, Patrick Joseph McCloskey, Kwok Pong Chan, Victor Petrovich Ostroverkhov, Matthew Jeremiah Misner, Vijay Krishna Paruchuru