Abstract: A composite sorbent composition comprising a polymeric adsorbent; and an extractant having the formula, or a hydrate thereof, wherein Z is —C(O)— or —C(R?)(R?)— wherein R? and R? are each hydroxyl; and R1, R2, R3, and R4 are each independently hydrogen, halogen, hydroxyl, cyano, nitro, amino, —C(O)H, —C(O)OH, —C(O)NH2, alkyl, alkenyl, alkynyl, alkoxy, alkanoyl, alkylamino, alkyl carboxamide, alkyl ester, heteroalkyl, haloalkyl, haloalkoxy, cycloalkyl, aryl, arylalkyl, aryloxy, heterocycloalkyl, heteroaryl, heteroaryloxy, or heteroarylalkyl, each of which R1, R2, R3, and R4 is unsubstituted or substituted with one or more substituents independently chosen from halogen, hydroxyl, WO 2019/023355 A1 cyano, nitro, sulphonato, amino, —C(O)H, —C(O)OH, —C(O)NH2, alkyl, alkoxy, alkylamino, heteroalkyl, haloalkyl, haloalkoxy, cycloalkyl, aryl, arylalkyl, aryloxy, heterocycloalkyl, heteroaryl, heteroaryloxy, or heteroarylalkyl; or R1 and R2, R2 and R3, or R3 and R4 are together a group —O—CH2—O—, a group —CH2—O—CH2—, or

Abstract: A composite sorbent composition comprising a polymeric adsorbent; and an extractant having the formula (I), or hydrate in thereof, wherein X is O or S, A1 and A2 are each independently —C(O)— or —C(R?)(R?)— wherein R?, and R? are each independently hydrogen, halogen, hydroxyl, cyano, nitro, amino, —CHO, —COOH, C1-12 alkyl, C1-4 alkoxy, C1-4 alkylamino, C1-2 haloalkyl, C1-2 haloalkoxy, C1-12 cycloalkyl, C6-12 aryl, C7-13 arylalkyl, C3-12 heteroaryl, C1-12 heteroalkyl, or C4-12 heteroarylalkyl, Z is a covalent bond, —S—, —O—, —SO2—, —SO—, —P(R)(?O)—, —NR—, -C(O)-, -C(O)NH-, —C(?N—R)—, or —C(R?)(R?)— wherein R, R?, and R? are each independently hydrogen, halogen, hydroxyl, cyano, nitro, amino, —CHO, —COOH, —C(O)NH2, C1-12 alkyl, C1-12 alkoxy, C1-12 alkylamino, C1-4 haloalkyl, C1-4 haloalkoxy, C4-12 cycloalkyl, C6-12 aryl, C7-13 arylalkyl, C3-12 heterocycloalkyl, C3-12 heteroaryl, C1-12 heteroalkyl, or C4-12 heteroarylalkyl, and R1 and R2 are each independently hydrogen, halogen, hydroxyl, cyano, nitro, amino, or

Abstract: The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and related compounds and methods of using benzodiazepine derivatives and related compounds as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, hyperproliferation, and the like.