Patents by Inventor Dnyandeo Ragho Rane

Dnyandeo Ragho Rane has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of cefixime
    Patent number: 8008478
    Abstract: The present invention provides an improved process for the preparation of Cefixime of formula (I), a cephalosporine antibiotic with an improved quality in regard to color and solubility. This process includes: (i) reaction of 7-?-(4-chloro-2-alkoxycarbonyl methoxyimino-3-oxobutyromido)-3-cephem-4-carboxylic acid (V) with thiourea at pH 5.0 to 6.0 at temperature 25-40° C. in water, (ii) carbon treatment to the reaction mixture in presence of sodium dithionite or ethylenediaminetetraacetic acid (EDTA) followed by filtration, (iii) acidification of the filtrate obtained in step (ii) to pH 2.0 to 3.0 with acid at 50-80° C. to give cefixime ester (IV) (iv) alkaline hydrolysis of cefixime ester of formula (IV) in water followed by acidification to pH 5.0 to 6.0, (v) precipitation of cefixime (I) by adding ketone solvent followed by acidification to pH 2.0 to 3 and (vi) isolation of solid.
    Type: Grant
    Filed: December 19, 2005
    Date of Patent: August 30, 2011
    Assignee: Lupin Limited
    Inventors: Om Dutt Tyagi, Dnyandeo Ragho Rane, Sanjay Mahajan, Yuvraj Atmaram Chavan
  • PROCESS FOR THE PREPARATION OF CEFIXIME
    Publication number: 20090227787
    Abstract: The present invention provides an improved process for the preparation of Cefixime of formula (I), a cephalosporine antibiotic with an improved quality in regard to color and solubility.
    Type: Application
    Filed: December 19, 2005
    Publication date: September 10, 2009
    Applicant: LUPIN LIMITED
    Inventors: Om Dutt Tyagi, Dnyandeo Ragho Rane, Sanjay Mahajan, Yuvraj Atmaram Chavan
  • Process for manufacture of a 4-bromo-2-oxyimino butyric acid and its derivatives
    Patent number: 6846952
    Abstract: A process for producing 4-bromo-2-oxyimino butyric acid, predominantly as the (Z)-isomer of formula (I), wherein R is hydrogen; a linear or branched C1-4 alkyl group; a linear or branched C1-4 alkyl group substituted by a carboxylic acid or an aryl group; a substituted or unsubstituted cyclic alkyl group of 3-6 carbon atoms or a substituted or unsubstituted aryl group. The product is produced by reacting bromine with a 2-(oxyimino)-3-oxo butyric acid derivative of formula (II) wherein R is as defined above and R1 is a tert-butyl group in presence of an organic solvent and in presence of a C1-4 alcohol and acetyl bromide at a temperature ranging from about ?15° C. to about +15° C. Bromine is used in a proportion of about 0.90 to about 1.35 moles per mole of compound (II), preferably 0.90 to 1.10 moles. The acetyl bromide is used in molar proportions of 0.9 to 2 moles per mole of compound (II), preferably 0.9 to 1.5 moles.
    Type: Grant
    Filed: June 7, 2002
    Date of Patent: January 25, 2005
    Assignee: Lupin Limited
    Inventors: Vinod Kumar Kansal, Dnyandeo Ragho Rane, Sanjay Deshmukh, Santosh Kumar Singh, Santosh Richaria, Susan Ajay Abraham
  • Process for manufacture of a 4-bromo-2-oxyimino butyric acid and its derivatives
    Publication number: 20040054224
    Abstract: A process for producing 4-bromo-2-oxyimino butyric acid, predominantly as the (Z)-isomer of formula (I), 1
    Type: Application
    Filed: June 26, 2003
    Publication date: March 18, 2004
    Inventors: Vinod Kumar Kansal, Dnyandeo Ragho Rane, Sanjay Deshmukh, Santosh Kumar Singh, Santosh Richaria, Susan Ajay Abraham