Abstract: Disclosed are indazole compounds and derivatives thereof for use as modulators of the activity of mitogen-activated protein kinase 4 (MEK4). The disclosed compounds include 3-arylindazoles and 3-amino-indazoles which may be formulated in pharmaceutical composition for treating cell proliferative diseases and disorders associated with MEK4 activity, including cancer.

Abstract: Methods, apparatuses, and systems associated with a sample testing device are provided.

Abstract: A fabrication method for protecting an electrical component on a semiconductor device when subjected to exposure to highly energized electrons, such as those emitted during e-beam irradiation, is provided. An example method may include doping one or more lead-out regions providing an electrical connection to the electrical component of the semiconductor device. In addition, the method may further include forming the electrical component to electrically connect to at least one of the one or more lead-out regions by doping the surface of the semiconductor substrate with a second dopant. Further, the method may include forming a protective barrier on the surface of the semiconductor substrate, substantially aligned with the one or more lead-out regions. The method may further comprise creating one or more cap regions substantially covering the entire surface of the semiconductor except for the lead-out regions by doping the surface of the semiconductor with a third dopant.

Abstract: A method for manufacturing a ceramic material for thermal energy storage, includes producing a mixture of at least particles of clay and particles of natural and/or synthetic phosphate, and water, the mixture comprising between 0.5% and 40% by weight of phosphate compared to the weight of the mixture with the exception of water, and shaping and firing of the mixture to obtain the ceramic material. A ceramic material for thermal energy storage includes: a matrix of clay and, if appropriate, sand, and particles of a natural and/or synthetic phosphate dispersed in the matrix, the ceramic material comprising between 0.5% and 40% by weight of phosphate compared to the weight of the ceramic material.

Abstract: An aircraft stringer lay-up assembly is provided comprising a contoured curing block and a first mandrel element positioned thereon. The first mandrel assembly includes a first bar assembly having a plurality of rigidity reducing first slots formed along a first mandrel length. The plurality of rigidity reducing first slots protruding partially through a first mandrel depth of the first mandrel element to allow the first bar assembly to conform to the contoured curing block. A composite ply assembly is laid up onto the first mandrel element and cured while conformed to said contoured curing block such that a contoured composite stringer element is generated.

Abstract: A method of manufacturing a unitary seamless section of an aircraft fuselage comprises disposing a thin lay-up mandrel element onto the outer shell surface of a cylindrical inner mandrel shell, thereby forming a mandrel with a lay-up surface. A plurality of resin impregnated stiffener fibers may be layed-up within a plurality of stiffener channels in the lay-up surface to form a plurality of stiffeners or stringers. The method further includes laying up a plurality of resin impregnated skin fibers onto the lay-up surface while the mandrel rotates to form a unitary pre-cured section of an aircraft fuselage.

Abstract: A method and article of manufacture of joining a stringer to a wing or tail panel and curing a wing or tail panel is disclosed. A sheet of titanium is placed between a cured stringer and an uncured wing or tail panel. The stringer, wing or tail panel and sheet are then placed within a vacuum bag, and gas is pumped out of the bag. The bag is then placed in an auto-clave to cure the wing or tail panel.

Abstract: An aircraft stringer lay-up assembly is provided comprising a first mandrel element having a first mandrel material with a first mandrel coefficient of thermal expansion. A composite ply assembly is laid up onto the first mandrel element to generate a primary lay-up surface. The composite ply assembly comprises a first primary fold-over portion folded onto to the first mandrel right end surface. A second primary fold over portion folds over to the first mandrel left end surface. The first mandrel coefficient of thermal expansion is adapted such that the first mandrel is movable between a first mandrel normal condition and a first mandrel heated condition where the first mandrel right end surface and the first mandrel left end surface move away from each other. The first primary fold-over portion and the secondary primary fold over portion are thereby moved such that wrinkles are pulled out of said primary lay-up surface.

Abstract: An aircraft stringer lay-up assembly is provided comprising a contoured curing block and a first mandrel element positioned thereon. The first mandrel assembly includes a first bar assembly having a plurality of rigidity reducing first slots formed along a first mandrel length. The plurality of rigidity reducing first slots protruding partially through a first mandrel depth of the first mandrel element to allow the first bar assembly to conform to the contoured curing block. A composite ply assembly is laid up onto the first mandrel element and cured while conformed to said contoured curing block such that a contoured composite stringer element is generated.

Abstract: A method and article of manufacture of joining a stringer to a wing or tail panel and curing a wing or tail panel is disclosed. A sheet of titanium is placed between a cured stringer and an uncured wing or tail panel. The stringer, wing or tail panel and sheet are then placed within a vacuum bag, and gas is pumped out of the bag. The bag is then placed in an auto-clave to cure the wing or tail panel.

Abstract: The gas-insulated line comprises a conductor (1A) disposed inside a case (3A) filled with a dielectric gas under pressure. A power capacitor (5) is electrically connected to the conductor while being disposed inside a compartment (3P) secured to the case (3A) and filled with a dielectric gas under pressure. The dielectric gas present in the compartment (3P) provides electrical insulation for the compartment relative to the power capacitor (5). In this way, electrical insulation of the gas-insulated line between the conductor (1A) and the case (3A) is maintained inside the compartment (3P) in which the power capacitor (5) and the conductor (1A) are electrically interconnected. This results in the gas-insulated line of the invention retaining small bulk and the ability to be used on the ground or buried.

Abstract: A polymer high voltage current limiter comprising, per phase, a fast circuit-breaker pole, a semi-fast protection circuit-breaker pole, and a set of polymer-based elements having very low resistivity, filled with carbon black, and connected in series and in parallel, wherein each element comprises a carbon-filled polymer matrix of elongate shape and including in its interior two parallel metal conductors.

Abstract: A gas-insulated cable having a plurality of lengths connected end to end, each length containing three conductors with the ends of the conductors of a length having respective metal endpieces engaging in respective cylindrical terminal metal portions of the corresponding conductors of the adjacent length, the terminal portions being provided with respective internal contacts co-operating with the endpieces, wherein a respective insulating sleeve of length substantially equal to twice its diameter is disposed around each of the endpieces and between the endpiece and the inside wall of the terminal portion.

Abstract: A gas-insulated cable includes a plurality of sections separated by sealed partitions, each section including a cylindrical steel case, a cylindrical aluminum screen coaxial with and inside the case and three conductors. A monitoring device includes, between the case and the screen, optical fibers equal in number to the number of sections of the cable and extending from one end to the other of the cable, each of the sections being monitored by a single fiber. The monitoring device further includes at least one optical internal arc detector inserted in series into each fiber in the corresponding monitored section, at each end of the device, a device for detecting light conveyed by the optical fibers, and at least one optical threshold temperature detector inserted in series into each fiber in the corresponding monitored section.

Abstract: A joint with a boss for fitting to an assembly compartment for assembling together two adjacent lengths of a long-distance gas-insulated three-phase cable, the joint including a boss containing the seats of an externally-controllable valve whose drive combinations make it possible to establish communication independently either between the inside volumes of adjacent lengths, or the outside of the cable with the inside volumes of both adjacent lengths, or the outside of the cable with the inside volumes of one only of the lengths.

Abstract: A gas-insulated high-tension three-phase electricity line which includes a cylindrical steel case and three conductors disposed parallel to the axis of the case, and a magnetic screen constituted by a cylindrical aluminum case placed inside the steel case and very close thereto. The conductors are held by a plurality of sets of three insulating arms secured to one another, the conductors being free to slide through openings formed in the arms, the aluminum case being separated from the steel case by strips of plastics material or of filled polymer having a low coefficient of friction.

Abstract: A gas-insulated single-phase cable for long-distance transport of electricity under high tension, the cable including a cylindrical steel case filled with nitrogen under a pressure of at least 10 hectopascals, an aluminum- or copper-based metal conductor held axially inside the steel case by closed insulating cones, and an aluminum case disposed at a short distance from the steel case and constituting a magnetic screen protecting the steel case from the magnetic field generated by the current carried by the conductor. The steel case is separated from the aluminum case by rings of plastics material or of filled polymer, such as polytetrafluoroethylene. Each rings is placed in a groove in a metal collar, with two adjacent portions of the aluminum case being welded to the collar.

Abstract: The present invention relates to a superconductive coil assembly which may be used particularly for a current limiter, the coil assembly comprising a plurality of coaxial cylindrical coils electrically connected in series, each coil comprising two windings of superconductive material electrically connected in parallel, arranged coaxially and wound in opposite directions, wherein in each coil, the windings are separated by a material which has a surface resistance in the radial direction lying in the range 10.sup.-5 .OMEGA..m.sup.2 to 10.sup.-2 .OMEGA..m.sup.2 at the temperature of the cryostat, and in which the strands which constitute the superconductive wires may themselves be covered with a layer of the same material.

Abstract: The present invention relates to an ultra-high-tension interrupting chamber comprising a main chamber including an insulating case containing permanent contacts, arcing contacts and two closing resistors inserted by means of semi-moving "make switch" device putting a "first" one of the resistors into operation before the "second" resistor. An auxiliary chamber is connected in parallel with the main chamber, which auxiliary chamber includes an insulating casing containing an opening varistor associated with a break switch having a slow-release opening mechanism situated inside the casing.

Abstract: A hybrid circuit-breaker for interrupting currents having high DC components, said hybrid circuit-breaker comprising a compressed-air circuit-breaker that re-closes automatically, and a sulfur hexafluoride circuit-breaker, the circuit-breakers being disposed in series.