Patents by Inventor Dolatrai Vyas

Dolatrai Vyas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PYRROLOTRIAZINE COMPOUNDS USEFUL AS KINASE INHIBITORS AND METHODS OF TREATING KINASE-ASSOCIATED CONDITIONS THEREWITH
    Publication number: 20070004731
    Abstract: The invention relates to at least one pyrrolotriazine derivative, at least one pharmaceutical composition comprising at least one pyrrolotriazine derivative, and at least one method of using at least one pyrrolotriazine derivative to treat at least one kinase associated condition.
    Type: Application
    Filed: June 27, 2006
    Publication date: January 4, 2007
    Applicant: Bristol-Myers Squibb Company
    Inventors: Harold Mastalerz, Dolatrai Vyas, George Trainor, Ashvinikumar Gavai
  • Pyrrolotriazine compounds
    Publication number: 20060014745
    Abstract: The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The compounds of the invention inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents. The compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
    Type: Application
    Filed: June 21, 2005
    Publication date: January 19, 2006
    Inventors: Ashvinikumar Gavai, Harold Mastalerz, Jean-Paul Daris, Pierre Dextraze, Philippe Lapointe, Edward Ruediger, Dolatrai Vyas, Guifen Zhang
  • Phosphonooxymethyl ethers of taxane derivatives
    Patent number: 6455575
    Abstract: The present invention concerns antitumor compounds. More particularly, the invention provides novel taxane derivatives, pharmaceutical compositions thereof, and their use as antitumor agents.
    Type: Grant
    Filed: June 6, 1997
    Date of Patent: September 24, 2002
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jerzy Golik, Dolatrai Vyas, John J. Wright, Henry Wong, John F. Kadow, John K. Thottathil, Wen-Sen Li, Murray A. Kaplan, Robert K. Perrone, Mark D. Wittman
  • PHOSPHONOOXYMETHYL ETHERS OF TAXANE DERIVATIVES
    Publication number: 20010023255
    Abstract: The present invention concerns antitumor compounds. More particularly, the invention provides novel taxane derivatives, pharmaceutical compositions thereof, and their use as antitumor agents.
    Type: Application
    Filed: June 6, 1997
    Publication date: September 20, 2001
    Inventors: JERZY GOLIK, DOLATRAI VYAS, JOHN J. WRIGHT, HENRY WONG, JOHN F. KADOW, JOHN K. THOTTATHIL, WEN-SEN LI, MURRAY A. KAPLAN, ROBERT K. PERRONE, MARK D. WITTMAN
  • Camptothecin &bgr;-alanine esters with topoisomerase I inhibition
    Patent number: 6288072
    Abstract: &bgr;-Alanine esters of camptothecin compounds which are effective anti-tumor compounds are disclosed. These compounds inhibit the enzyme topoisomerase I and may alkylate DNA of the associated topoisomerase I-DNA cleavable complex.
    Type: Grant
    Filed: December 29, 1999
    Date of Patent: September 11, 2001
    Inventors: Monroe E. Wall, Mansukh C. Wani, Govindarajan Manikumar, Neelakantan Balasubramanian, Dolatrai Vyas
  • 10, 11-difluoromethylenedioxycamptothecin compounds with topoisomerase I inhibition
    Patent number: 6268375
    Abstract: Camptothecin compounds having a C10 11 O—(CF2)nO group where n is 1 or 2 are effective anti-tumor compounds. These compounds inhibit the enzyme topoisomerase I and may alkylate DNA of the associated topoisomerase I-DNA cleavable complex.
    Type: Grant
    Filed: December 29, 1999
    Date of Patent: July 31, 2001
    Assignees: Research Triangle Institute, Bristol-Myers Squibb Company
    Inventors: Monroe E. Wall, Mansukh C. Wani, Govindarajan Manikumar, Neelakantan Balasubramanian, Dolatrai Vyas
  • Phosphonooxymethyl ethers of taxane derivatives
    Patent number: 5646176
    Abstract: The present invention concerns antitumor compounds. More particularly, the invention provides novel taxane derivatives, pharmaceutical compositions thereof, and their use as antitumor agents.
    Type: Grant
    Filed: May 19, 1995
    Date of Patent: July 8, 1997
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jerzy Golik, Dolatrai Vyas, John J. Wright, Henry Wong, John F. Kadow, John K. Thottathil, Wen-Sen Li, Murray A. Kaplan, Robert K. Perrone, Mark D. Wittman