Abstract: Concentrations are determined based on a measurement of a composition (X) by Laser Induced Breakdown Spectroscopy (LIBS). The LIBS spectrum (Sx) comprises resonance peaks (Rk,Rca,Rna) corresponding to the constituents (K,Ca,Na) in the composition (X). The resonance peaks comprise spectral amplitudes (Pk,Pca,Dna,Pna) indicative of the unknown concentrations (Cna,Ck,Cca) of the constituents (K,Ca,Na). A first spectral amplitude (Pk,Pca,Dna) in the LIBS spectrum (Sx) corresponds to the unknown concentration (Ck,Cca,Cna) of a first constituent (K,Ca,Na) to be determined. A second spectral amplitude (Pna) corresponds to a maximum value of a self-reversed resonance peak (Rna) of the first or another constituent (Na) in the LIBS spectrum (Sx). An amplitude ratio (Pk/Pna, Pca/Pna, Dna/Pna) is calculated between the first spectral amplitude (Pk,Pca,Dna) and the second spectral amplitude (Pna) and the ratio is matched with calibration data to determine concentrations.

Abstract: A spectroscopy device is disclosed for inline monitoring of analytes in bulk fluid streams, capable of maintaining sterile conditions. The device comprises a cassette suitable for holding a fluid analyte (151) and having a laser entry wall part and a detector wall part, the laser entry wall part arranged to be optically transparent to laser radiation of a predetermined wavelength and the detector wall part arranged to be optically transparent for spectral parts of interest. Laser transmission optics are provided to focus a laser beam to produce a breakdown plasma discharge within the fluid inside the cassette. A photodetector substrate is provided comprising an array of photosensors, tuned to detect characteristic emission lines from the plasma. The photodetector substrate is conformal to at least the detector wall part of the cassette. A placement provision is arranged for user removable placement of the cassette.

Abstract: A spectroscopy device is disclosed for inline monitoring of analytes in bulk fluid streams, capable of maintaining sterile conditions. The device comprises a cassette suitable for holding a fluid analyte (151) and having a laser entry wall part and a detector wall part, the laser entry wall part arranged to be optically transparent to laser radiation of a predetermined wavelength and the detector wall part arranged to be optically transparent for spectral parts of interest. Laser transmission optics are provided to focus a laser beam to produce a breakdown plasma discharge within the fluid inside the cassette. A photodetector substrate is provided comprising an array of photosensors, tuned to detect characteristic emission lines from the plasma. The photodetector substrate is conformal to at least the detector wall part of the cassette. A placement provision is arranged for user removable placement of the cassette.